Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review

Nouri Z, Fakhri S, Nouri K, Wallace CE, Farzaei MH, Bishayee A. Targeting multiple signaling pathways in cancer: the rutin therapeutic approach. Cancers. 2020;12(8):2276.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Gilbertson RJ. Mapping cancer origins. Cell. 2011;145(1):25–9.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Singh AK, Bishayee A, Pandey AK. Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy. Nutrients. 2018;10(6):731.

Article  PubMed Central  PubMed  Google Scholar 

Moar K, Pant A, Saini V, Maurya PK. Potential biomarkers in endometrial cancer: a narrative review. Biomarkers. 2023;28(4):358–71.

Article  CAS  PubMed  Google Scholar 

Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727–47.

Article  CAS  PubMed  Google Scholar 

Chikara S, Nagaprashantha LD, Singhal J, Horne D, Awasthi S, Singhal SS. Oxidative stress and dietary phytochemicals: role in cancer chemoprevention and treatment. Cancer Lett. 2018;413:122–34.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Zheng J, Li Y, Xu D-P, Li S, Chen Y-M, et al. Natural polyphenols for prevention and treatment of cancer. Nutrients. 2016;8(8):515.

Article  PubMed Central  PubMed  Google Scholar 

Fu L, Xu B-T, Xu X-R, Qin X-S, Gan R-Y, Li H-B. Antioxidant capacities and total phenolic contents of 56 wild fruits from South China. Molecules. 2010;15(12):8602–17.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Deng G-F, Lin X, Xu X-R, Gao L-L, Xie J-F, Li H-B. Antioxidant capacities and total phenolic contents of 56 vegetables. J Funct Foods. 2013;5(1):260–6.

Article  CAS  Google Scholar 

Spencer JP, Abd El Mohsen MM, Minihane A-M, Mathers JC. Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr. 2008;99(1):12–22.

Article  CAS  PubMed  Google Scholar 

Nacka-Aleksić M, Pirković A, Vilotić A, Bojić-Trbojević Ž, Jovanović Krivokuća M, Giampieri F, et al. The role of dietary polyphenols in pregnancy and pregnancy-related disorders. Nutrients. 2022;14(24):5246.

Article  PubMed Central  PubMed  Google Scholar 

Luca SV, Macovei I, Bujor A, Miron A, Skalicka-Woźniak K, Aprotosoaie AC, et al. Bioactivity of dietary polyphenols: the role of metabolites. Crit Rev Food Sci Nutr. 2020;60(4):626–59.

Article  CAS  PubMed  Google Scholar 

Ohishi T, Fukutomi R, Shoji Y, Goto S, Isemura M. The beneficial effects of principal polyphenols from green tea, coffee, wine, and curry on obesity. Molecules. 2021;26(2):453.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Pereira L, Cotas JJ. Therapeutic potential of polyphenols and other micronutrients of marine origin. Mar Drugs. 2023;21(6):323.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li H-B. Dietary natural products for prevention and treatment of liver cancer. Nutrients. 2016;8(3):156.

Article  PubMed Central  PubMed  Google Scholar 

Patra S, Pradhan B, Nayak R, Behera C, Das S, Patra SK, et al. Dietary polyphenols in chemoprevention and synergistic effect in cancer: clinical evidences and molecular mechanisms of action. Phytomedicine. 2021;90:153554.

Article  CAS  PubMed  Google Scholar 

Valletta A, Iozia LM, Leonelli F. Impact of environmental factors on stilbene biosynthesis. Plants. 2021;10(1):90.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013;2013:1–16.

Article  Google Scholar 

de Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol. 1998;12(3):249–55.

Article  PubMed  Google Scholar 

Roche A, Ross E, Walsh N, O’Donnell K, Williams A, Klapp M, et al. Representative literature on the phytonutrients category: phenolic acids. Crit Rev Food Sci Nutr. 2017;57(6):1089–96.

Article  CAS  PubMed  Google Scholar 

Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29(2):95–120.

Article  CAS  PubMed  Google Scholar 

Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, et al. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009;1:25–37.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70(22):9003–11.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Howells LM, Berry D, Elliott P, Jacobson E, Hoffmann E, Hegarty B, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases—safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res. 2011;4(9):1419–25.

Article  CAS  Google Scholar 

Popat R, Plesner T, Davies F, Cook G, Cook M, Elliott P, et al. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol. 2013;160(5):714–7.

Article  CAS  PubMed  Google Scholar 

Seufferlein T, Ettrich TJ, Menzler S, Messmann H, Kleber G, Zipprich A, et al. Green tea extract to prevent colorectal adenomas, results of a randomized, placebo-controlled clinical trial. Am J Gastroenterol. 2022;117(6):884–94.

Article  PubMed  Google Scholar 

Zhao H, Zhu W, Zhao X, Li X, Zhou Z, Zheng M, et al. Efficacy of Epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy: a double-blind, placebo-controlled, phase 2 randomized clinical trial. JAMA Dermatol. 2022;158(7):779–86.

Article  PubMed Central  PubMed  Google Scholar 

Porcaro G, Santamaria A, Giordano D, Angelozzi P. Vitamin D plus epigallocatechin gallate: a novel promising approach for uterine myomas. Eur Rev Med Pharmacol Sci. 2020;24(6):3344–51.

CAS  PubMed  Google Scholar 

Nuñez-Sánchez MA, González-Sarrías A, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, et al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. J Nutr Biochem. 2017;42:126–33.

Article  PubMed  Google Scholar 

Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 2008;14(14):4491–9.

Article  CAS  PubMed  Google Scholar 

Thambamroong T, Seetalarom K, Saichaemchan S, Pumsutas Y, Prasongsook N. Efficacy of curcumin on treating cancer anorexia-cachexia syndrome in locally or advanced head and neck cancer: a double-blind, placebo-controlled randomised phase IIa trial (CurChexia). J Nutr Metab. 2022;2022:5425619.

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