Responses to Exercise with Low Carbohydrate Availability on Muscle Glycogen and Cell Signaling: A Systematic Review and Meta-analysis

Burke LM, Van Loon LJC, Hawley JA. Postexercise muscle glycogen resynthesis in humans. J Appl Physiol. 2017;122:1055–67.

Article  CAS  PubMed  Google Scholar 

Richter EA, Sylow L, Hargreaves M. Interactions between insulin and exercise. Biochem J. 2021;478:3827–46.

Article  CAS  PubMed  Google Scholar 

Jensen J, Rustad PI, Kolnes AJ, Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol. 2011. https://doi.org/10.3389/fphys.2011.00112.

Article  PubMed  PubMed Central  Google Scholar 

Burke LM, Hawley JA. Swifter, higher, stronger: what’s on the menu? Science (1979). 2018;362:781–7.

CAS  Google Scholar 

Jeukendrup AE. Periodized nutrition for athletes. Sports Med. 2017;47:51–63.

Article  PubMed  PubMed Central  Google Scholar 

Bartlett JD, Hawley JA, Morton JP. Carbohydrate availability and exercise training adaptation: too much of a good thing? Eur J Sport Sci. 2015;15:3–12.

Article  PubMed  Google Scholar 

Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014;159:738–49.

Article  CAS  PubMed  Google Scholar 

Burke LM, Hawley JA, Jeukendrup A, Morton JP, Stellingwerff T, Maughan RJ. Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport. Int J Sport Nutr Exerc Metab. 2018;28:451–63.

Article  PubMed  Google Scholar 

Impey SG, Hearris MA, Hammond KM, Bartlett JD, Louis J, Close GL, et al. Fuel for the work required: a theoretical framework for carbohydrate periodization and the glycogen threshold hypothesis. Sports Med. 2018;48:1031–48.

Article  PubMed  PubMed Central  Google Scholar 

Hawley JA, Morton JP. Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clin Exp Pharmacol Physiol. 2014;41:608–13.

Article  CAS  PubMed  Google Scholar 

Cochran AJR, Little JP, Tarnopolsky MA, Gibala MJ. Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans. J Appl Physiol. 2010;108:628–36.

Article  CAS  PubMed  Google Scholar 

Psilander N, Frank P, Flockhart M, Sahlin K. Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle. Eur J Appl Physiol. 2013;113:951–63.

Article  CAS  PubMed  Google Scholar 

Bartlett JD, Louhelainen J, Iqbal Z, Cochran AJ, Gibala MJ, Gregson W, et al. Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis. Am J Physiol Regul Integr Comp Physiol. 2013;304:450–8.

Article  Google Scholar 

Ramos C, Cheng AJ, Kamandulis S, Subocius A, Brazaitis M, Venckunas T, et al. Carbohydrate restriction following strenuous glycogen-depleting exercise does not potentiate the acute molecular response associated with mitochondrial biogenesis in human skeletal muscle. Eur J Appl Physiol. 2021;121:1219–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hammond KM, Sale C, Fraser W, Tang J, Shepherd SO, Strauss JA, et al. Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation. J Physiol. 2019;597:4779–96.

Article  CAS  PubMed  Google Scholar 

Jensen L, Gejl KD, Ørtenblad N, Nielsen JL, Bech RD, Nygaard T, et al. Carbohydrate restricted recovery from long term endurance exercise does not affect gene responses involved in mitochondrial biogenesis in highly trained athletes. Physiol Rep. 2015;3:1–13.

Article  Google Scholar 

Hearris MA, Hammond KM, Seaborne RA, Stocks B, Shepherd SO, Philp A, et al. Graded reductions in preexercise muscle glycogen impair exercise capacity but do not augment skeletal muscle cell signaling: Implications for CHO periodization. J Appl Physiol. 2019;126:1587–97.

Article  CAS  PubMed  Google Scholar 

Cluberton LJ, McGee SL, Murphy RM, Hargreaves M. Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression. J Appl Physiol. 2005;99:1359–63.

Article  CAS  PubMed  Google Scholar 

Mathai AS, Bonen A, Benton CR, Robinson DL, Graham TE. Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle. J Appl Physiol. 2008;105:1098–105.

Article  CAS  PubMed  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG, Antes G, Atkins D, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.

Article  PubMed  PubMed Central  Google Scholar 

Valentine JC, Pigott TD, Rothstein HR. How many studies do you need? A primer on statistical power for meta-analysis. J Educ Behav Stat. 2010;35:215–47.

Article  Google Scholar 

Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA, et al. Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab. 2006;31:302–12.

Article  CAS  PubMed  Google Scholar 

Arkinstall MJ, Tunstall RJ, Cameron-Smith D, Hawley JA. Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation. Am J Physiol Endocrinol Metab. 2004;287:E25–31.

Article  CAS  PubMed  Google Scholar 

Savović J, Weeks L, Sterne JAC, Turner L, Altman DG, Moher D, et al. Evaluation of the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials: focus groups, online survey, proposed recommendations and their implementation. Syst Rev. 2014. https://doi.org/10.1186/2046-4053-3-37.

Article  PubMed  PubMed Central  Google Scholar 

Preobrazenski N, McCaig A, Turner A, Kushner M, Pacitti L, Mendolia P, et al. Risk of bias in exercise science: a systematic review of 340 studies. iScience. 2024;27:109010.

Article  PubMed  PubMed Central  Google Scholar 

Follmann D, Elliott P, Suh I, Cutler J. Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol. 1992;45:769–73.

Article  CAS  PubMed  Google Scholar 

Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41:3–12.

Article  PubMed  Google Scholar 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. In: Cochrane handbook for systematic reviews of interventions. Hoboken: Wiley; 2019.

Gejl KD, Nybo L. Performance effects of periodized carbohydrate restriction in endurance trained athletes—a systematic review and meta-analysis. J Int Soc Sports Nutr. 2021. https://doi.org/10.1186/s12970-021-00435-3.

Article  PubMed  PubMed Central  Google Scholar 

Chan MHS, McGee SL, Watt MJ, Hargreaves M, Febbraio MA. Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. FASEB J. 2004;18:1785–7.

Article  CAS  PubMed  Google Scholar 

Wojtaszewski JFP, MacDonald C, Nielsen JN, Hellsten Y, Grahame Hardie D, Kemp BE, et al. Regulation of 5′-AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab. 2003;284:813–21.

Article  Google Scholar 

Pilegaard H, Osada T, Andersen LT, Helge JW, Saltin B, Neufer PD. Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. Metabolism. 2005;54:1048–55.

Article  CAS  PubMed  Google Scholar 

Lane SC, Camera DM, Lassiter DG, Areta JL, Bird SR, Yeo WK, et al. Effects of sleeping with reduced carbohydrate availability on acute training responses. J Appl Physiol. 2015;119:643–55.

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