Impact of dose volume parameters and clinical characteristics on radiation-induced acute oral mucositis for head and neck cancer patients treated with carbon-ion radiotherapy dose volume outcome analysis

Elting LS, Keefe DM, Sonis ST, Garden AS, Spijkervet FK, Barasch A et al (2008) Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer-am Cancer Soc 113:2704–2713

Google Scholar 

Chung YL, Pui N (2017) Confounding factors associated with oral mucositis assessment in patients receiving chemoradiotherapy for head and neck cancer. Support Care Cancer 25:2743–2751

Article  PubMed  Google Scholar 

Russo G, Haddad R, Posner M, Machtay M (2008) Radiation treatment breaks and ulcerative mucositis in head and neck cancer. Oncologist 13:886–898

Article  PubMed  Google Scholar 

Durante M, Orecchia R, Loeffler JS (2017) Charged-particle therapy in cancer: clinical uses and future perspectives. Nat Rev Clin Oncol 14:483–495

Article  PubMed  Google Scholar 

Lambin P, Roelofs E, Reymen B, Velazquez ER, Buijsen J, Zegers CM et al (2013) ‘Rapid Learning health care in oncology—an approach towards decision support systems enabling customised radiotherapy. Radiother Oncol 109:159–164

Article  PubMed  Google Scholar 

Langendijk JA, Lambin P, De Ruysscher D, Widder J, Bos M, Verheij M (2013) Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach. Radiother Oncol 107:267–273

Article  CAS  PubMed  Google Scholar 

Kierkels RG, Korevaar EW, Steenbakkers RJ, Janssen T, Van’T VA, Langendijk JA et al (2014) Direct use of multivariable normal tissue complication probability models in treatment plan optimisation for individualised head and neck cancer radiotherapy produces clinically acceptable treatment plans. Radiother Oncol 112:430–436

Article  PubMed  Google Scholar 

Dehing-Oberije C, De Ruysscher D, Petit S, Van Meerbeeck J, Vandecasteele K, De Neve W et al (2010) Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients. Radiother Oncol 97:455–461

Article  PubMed  Google Scholar 

Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB et al (2010) Quantitative Analyses of Normal Tissue Effects in the Clinic (Quantec): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys 76:S3–9

Article  PubMed  PubMed Central  Google Scholar 

Moncharmont C, Vallard A, Mengue NS, Guy JB, Saget C, Mery B et al (2016) Real-life assessment of Volumetric Modulated Arc Therapy (VMAT) toxicity in Head and Neck Squamous Cell Carcinoma (HNSCC) treatment. Acta Otolaryngol 136:181–188

Article  CAS  PubMed  Google Scholar 

Bahl A, Oinam AS, Kaur S, Verma R, Elangovan A, Bhandari S et al (2017) Evaluation of Acute Toxicity and Early Clinical Outcome in Head and Neck Cancers Treated With Conventional Radiotherapy and Simultaneous Integrated Boost Arc Radiotherapy. World J Oncol 8:117–121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lambrecht M, Nevens D, Nuyts S (2013) Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy. Effect on outcome and toxicity in locally advanced head and neck cancer. Strahlenther Onkol 189:223–229

Article  CAS  PubMed  Google Scholar 

Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122

Article  CAS  PubMed  Google Scholar 

Chen AM, Yoshizaki T, Velez MA, Mikaeilian AG, Hsu S, Cao M (2017) Tolerance of the Brachial Plexus to High-Dose Reirradiation. Int J Radiat Oncol Biol Phys 98:83–90

Article  PubMed  Google Scholar 

Scott-Brown M, Miah A, Harrington K, Nutting C (2010) Evidence-based review: quality of life following head and neck intensity-modulated radiotherapy. Radiother Oncol 97:249–257

Article  PubMed  Google Scholar 

Mallick S, Benson R, Rath GK (2016) Radiation induced oral mucositis: a review of current literature on prevention and management. Eur Arch Otorhinolaryngol 273:2285–2293

Article  PubMed  Google Scholar 

Moslemi D, Nokhandani AM, Otaghsaraei MT, Moghadamnia Y, Kazemi S, Moghadamnia AA (2016) Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: A review of the current literature. Radiother Oncol 120:13–20

Article  PubMed  Google Scholar 

Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J (2015) Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Ann Oncol 26(Suppl 5):v139–51

Article  PubMed  Google Scholar 

Werbrouck J, De Ruyck K, Duprez F, Veldeman L, Claes K, Van Eijkeren M et al (2009) Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes. Int J Radiat Oncol Biol Phys 73:1187–1195

Article  CAS  PubMed  Google Scholar 

Mazzola R, Ricchetti F, Fersino S, Fiorentino A, Giaj Levra N, Di Paola G et al (2016) Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose-volume analysis. Head Neck 38:

Li K, Yang L, Xin P, Chen Y, Hu QY, Chen XZ et al (2017) Impact of dose volume parameters and clinical factors on acute radiation oral mucositis for locally advanced nasopharyngeal carcinoma patients treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy. Oral Oncol 72:32–37

Article  PubMed  Google Scholar 

Musha A, Shimada H, Shirai K, Saitoh J, Yokoo S, Chikamatsu K et al (2015) Prediction of Acute Radiation Mucositis using an Oral Mucosal Dose Surface Model in Carbon Ion Radiotherapy for Head and Neck Tumors. PLoS ONE 10:e141734

Article  Google Scholar 

Bansal A, Bedi N, Kaur R, Singh G, Benipal RPS, Dangwal V (2023) Correlation of oral mucosa dose and volume parameters with Grade 3 mucositis, in patients treated with volumetric modulated arc radiotherapy for oropharyngeal cancer? Jpn J Clin Oncol 53:313–320

Article  PubMed  Google Scholar 

Li K, Yang L, Hu QY, Chen XZ, Chen M, Chen Y (2017) Oral Mucosa Dose Parameters Predicting Grade 〉/=3 Acute Toxicity in Locally Advanced Nasopharyngeal Carcinoma Patients Treated With Concurrent Intensity-Modulated Radiation Therapy and Chemotherapy: An Independent Validation Study Comparing Oral Cavity versus Mucosal Surface Contouring Techniques. Transl Oncol 10:752–759

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif