Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17):1731–1740
Article CAS PubMed Google Scholar
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK et al (2021) Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol 22(1):29–42
Article CAS PubMed Google Scholar
Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D (2018) Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis. Ann Oncol 29(4):iv263
Article CAS PubMed Google Scholar
Habr-Gama A, Perez RO, Nadalin W, Sabbaga J, Ribeiro U Jr., Silvae Sousa AH Jr., Campos FG, Kiss DR, Gama-Rodrigues J (2004) Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy. Ann Surg 240(4):711–717 (discussion 717–718)
Article PubMed Central PubMed Google Scholar
Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, Verheij FS, Omer DM, Lee M, Dunne RF et al (2022) Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J Clin Oncol 40(23):2546–2556
Article CAS PubMed Central PubMed Google Scholar
Gerard JP, Barbet N, Schiappa R, Magné N, Martel I, Mineur L, Deberne M, Zilli T, Dhadda A, Myint AS (2023) Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x‑ray brachytherapy boost or external beam radiotherapy boost for organ preservation in early cT2–cT3 rectal adenocarcinoma (OPERA): a phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol 8(4):356–367
Ott OJ, Gani C, Lindner LH, Schmidt M, Lamprecht U, Abdel-Rahman S, Hinke A, Weissmann T, Hartmann A, Issels RD et al (2021) Neoadjuvant chemoradiation combined with regional hyperthermia in locally advanced or recurrent rectal cancer. Cancers 13(6)
Gani C, Lamprecht U, Ziegler A, Moll M, Gellermann J, Heinrich V, Wenz S, Fend F, Königsrainer A, Bitzer M et al (2021) Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial. Radiother Oncol 159:155–160
Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C, Becker H, Raab HR, Villanueva MT, Witzigmann H et al (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 30(16):1926–1933
Article CAS PubMed Google Scholar
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D et al (2021) Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 22(5):702–715
Article CAS PubMed Google Scholar
Schroeder C, Gani C, Lamprecht U, von Weyhern CH, Weinmann M, Bamberg M, Berger B (2012) Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia 28(8):707–714
Article CAS PubMed Google Scholar
Schem B‑C, Pfeffer F, Ott MA, Wiig JN, Sletteskog N, Frøystein T, Myklebust MP, Leh S, Dahl O, Mella O (2022) Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas. Cancers 14(3):705
Article CAS PubMed Central PubMed Google Scholar
Maluta S, Romano M, Dall’oglio S, Genna M, Oliani C, Pioli F, Gabbani M, Marciai N, Palazzi M (2010) Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum. Int J Hyperthermia 26(2):108–117
Article CAS PubMed Google Scholar
Stewart LA, Clarke M, Rovers M, Riley RD, Simmonds M, Stewart G, Tierney JF (2015) Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data: the PRISMA-IPD Statement. JAMA 313(16):1657–1665
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15):2008–2012
Article CAS PubMed Google Scholar
Mueller M, D’Addario M, Egger M, Cevallos M, Dekkers O, Mugglin C, Scott P (2018) Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations. BMC Med Res Methodol 18(1):44
Article PubMed Central PubMed Google Scholar
Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605
GA Wells BS, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2000) The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ (2008) What is “quality of evidence” and why is it important to clinicians? BMJ 336(7651):995–998
Article PubMed Central Google Scholar
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
Article CAS PubMed Google Scholar
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560
Article PubMed Central Google Scholar
Baujat B, Mahé C, Pignon JP, Hill C (2002) A graphical method for exploring heterogeneity in meta-analyses: application to a meta-analysis of 65 trials. Stat Med 21(18):2641–2652
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634
Article CAS PubMed Central Google Scholar
Gani C, Schroeder C, Heinrich V, Spillner P, Lamprecht U, Berger B, Zips D (2016) Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer. Int J Hyperthermia 32(2):187–192
Article CAS PubMed Google Scholar
Kang MK, Kim MS, Kim JH (2011) Clinical outcomes of mild hyperthermia for locally advanced rectal cancer treated with preoperative radiochemotherapy. Int J Hyperthermia 27(5):482–490
Wang Y, Lu S, Shao Y, Peng R, Li X, Wang J, Wang H (2022) Deep regional hyperthermia combined with modern concurrent chemoradiotherapy increases T‑downstaging rate in locally advanced rectal cancer. Int J Hyperthermia 39(1):431–436
Article CAS PubMed Google Scholar
Lee Y, Kim S, Cha H, Han JH, Choi HJ, Go E, You SH (2022) Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer. Cancers 14(5)
Shoji H, Motegi M, Takakusagi Y, Asao T, Kuwano H, Takahashi T, Ogoshi K (2017) Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses. Oncol Rep 37(2):695–704
Article CAS PubMed Google Scholar
Kato T, Fujii T, Ide M, Takada T, Sutoh T, Morita H, Yajima R, Yamaguchi S, Tsutsumi S, Asao T et al (2014) Effect of long interval between hyperthermochemoradiation therapy and surgery for rectal cancer on apoptosis, proliferation and tumor response. Anticancer Res 34(6):3141–3146
Barsukov YA, Gordeyev SS, Tkachev SI, Fedyanin MY, Perevoshikov AG (2013) Phase II study of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer. Colorectal Dis 15(9):1107–1114
Rau B, Wust P, Hohenberger P, Löffel J, Hünerbein M, Below C, Gellermann J, Speidel A, Vogl T, Riess H et al (1998) Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer. Ann Surg 227(3):380–389
Article CAS PubMed Central PubMed Google Scholar
Gani C, Polat B, Ott O, Germer E, Königsrainer A, Kirschniak A, Clasen S, Grosse U, Diefenhardt M, Bitzer M et al (2022) OC-0833 Total neoadjuvant therapy for Organ Preservation in Rectal Cancer: The CAO/ARO/AIO-16 phase II trial. Radiother Oncol 170:751
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