High Prevalence of Anti-Prothrombin IgM and IgG Autoantibodies in Women With Unexplained Recurrent Pregnancy Loss

Tomkiewicz J, Darmochwał-Kolarz D. The diagnostics and treatment of recurrent pregnancy loss. J Clin Med. 2023;12:4768.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turesheva A, Aimagambetova G, Ukybassova T, Marat A, Kanabekova P, Kaldygulova L, et al. Recurrent pregnancy loss etiology, risk factors, diagnosis, and management. Fresh look into a full box. J Clin Med. 2023;12:4074.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hennessy M, Dennehy R, Meaney S, Devane D, O’Donoghue K. A protocol for a systematic review of clinical practice guidelines for recurrent miscarriage. HRB Open Res. 2020;3:12.

Article  PubMed  PubMed Central  Google Scholar 

Vomstein K, Feil K, Strobel L, Aulitzky A, Hofer-Tollinger S, Kuon RJ, et al. Immunological risk factors in recurrent pregnancy loss: guidelines versus current state of the art. J Clin Med. 2021;10:869.

Article  PubMed  PubMed Central  Google Scholar 

Almawi WY, Al-Shaikh FS, Melemedjian OK, Almawi AW. Protein Z, an anticoagulant protein with expanding role in reproductive biology. Reproduction. 2013;146:R73–80.

Article  CAS  PubMed  Google Scholar 

Kirovakov Z, Konova E, Hinkova N, Markova S, Penchev P. Immunological risk factors in recurrent pregnancy loss in patients with hereditary thrombophilia. Cureus. 2024;16:e56555.

PubMed  PubMed Central  Google Scholar 

Mukhtar B, Garg R, Ibrahim G, Batra J. Investigating protein C and S levels in pregnant women with recurrent early pregnancy loss versus normal pregnancy. J Med Life. 2023;16:160–6.

Article  PubMed  PubMed Central  Google Scholar 

Sater MS, Finan RR, Al-Hammad SA, Mohammed FA, Issa AA, Almawi WY. High frequency of anti-protein Z IgM and IgG autoantibodies in women with idiopathic recurrent spontaneous miscarriage. Am J Reprod Immunol. 2011;65:526–31.

Article  CAS  PubMed  Google Scholar 

Li J, Wang L, Ding J, Cheng Y, Diao L, Li L, et al. Multiomics studies investigating recurrent pregnancy loss: an effective tool for mechanism exploration. Front Immunol. 2022;13:826198.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yonezawa M, Kuwabara Y, Ono S, Ouchi N, Ichikawa T, Takeshita T. Significance of anti-phosphatidylethanolamine antibodies in the pathogenesis of recurrent pregnancy lLoss. Reprod Sci. 2020;27:1888–93.

Article  CAS  PubMed  Google Scholar 

Mahjoub T, Mtiraoui N, Tamim H, Hizem S, Finan RR, Nsiri B, et al. Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages. Am J Hematol. 2005;80:12–9.

Article  CAS  PubMed  Google Scholar 

Bertolaccini ML, Sciascia S, Murru V, Garcia-Fernandez C, Sanna G, Khamashta MA. Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant. Thromb Haemost. 2013;109:207–13.

Article  CAS  PubMed  Google Scholar 

Go H, Ohto H, Nollet KE, Kashiwabara N, Ogasawara K, Chishiki M, et al. Perinatal factors affecting coagulation parameters at birth in preterm and term neonates: A retrospective cohort study. Am J Perinatol. 2019;36:1464–70.

Article  PubMed  Google Scholar 

Hubben A, McCrae KR. How to diagnose and manage antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2023;2023:606–13.

Article  PubMed  Google Scholar 

Ortel TL, Meleth S, Catellier D, Crowther M, Erkan D, Fortin PR, et al. Recurrent thrombosis in patients with antiphospholipid antibodies and an initial venous or arterial thromboembolic event: A systematic review and meta-analysis. J Thromb Haemost. 2020;18:2274–86.

Article  CAS  PubMed  Google Scholar 

Long Y, Huang C, Cui Y, Xie Z, Zhou Y, Shi X, et al. Cluster analysis of antiphospholipid antibodies-associated adverse pregnancy outcome patients: based on a 13-years cohort study. Clin Exp Med. 2023;23:5377–88.

Article  CAS  PubMed  Google Scholar 

Sater MS, Finan RR, Abu-Hijleh FM, Abu-Hijleh TM, Almawi WY. Anti-phosphatidylserine, anti-cardiolipin, anti-β2 glycoprotein I and anti-prothrombin antibodies in recurrent miscarriage at 8–12 gestational weeks. Eur J Obstet Gynecol Reprod Biol. 2012;163:170–4.

Article  CAS  PubMed  Google Scholar 

Delarue A, Dragon-Durey MA, Darnige L. Contribution of antiphosphatidylserine/prothrombin (anti-PS/PT) antibody detection in the diagnosis and management of antiphospholipid syndrome (APS). Rev Med Interne. 2022;43:545–51.

Article  CAS  PubMed  Google Scholar 

Sater MS, Finan RR, Mustafa FE, Al-Khateeb GM, Almawi WY. Anti-annexin V IgM and IgG autoantibodies and the risk of idiopathic recurrent spontaneous miscarriage. J Reprod Immunol. 2011;89:78–83.

Article  CAS  PubMed  Google Scholar 

Marozio L, Curti A, Botta G, Canuto EM, Salton L, Tavella AM, et al. Anti-prothrombin antibodies are associated with adverse pregnancy outcome. Am J Reprod Immunol. 2011;66:404–9.

Article  CAS  PubMed  Google Scholar 

Shoenfeld Y, Carp HJ, Molina V, Blank M, Cervera R, Balasch J, et al. Autoantibodies and prediction of reproductive failure. Am J Reprod Immunol. 2006;56:337–44.

Article  CAS  PubMed  Google Scholar 

Ticconi C, Nicastri E, D’Ippolito S, Chiaramonte C, Pietropolli A, Scambia G, et al. Diagnostic factors for recurrent pregnancy loss: an expanded workup. Arch Gynecol Obstet. 2023;308:127–42.

Article  PubMed  PubMed Central  Google Scholar 

Mtiraoui N, Zammiti W, Fekih M, Hider S, Almawi WY, Mahjoub T. Lupus anticoagulant and antibodies to beta 2-glycoprotein I, annexin V, and cardiolipin as a cause of recurrent spontaneous abortion. Fertil Steril. 2007;88:1458–61.

Article  CAS  PubMed  Google Scholar 

Zammiti W, Mtiraoui N, Kallel C, Mercier E, Almawi WY, Mahjoub T. A case-control study on the association of idiopathic recurrent pregnancy loss with autoantibodies against beta2-glycoprotein I and annexin V. Reproduction. 2006;131:817–22.

Article  CAS  PubMed  Google Scholar 

de Moreuil C, Mehic D, Nopp S, Kraemmer D, Gebhart J, Schramm T, et al. Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis. Blood Adv. 2023;7:5954–67.

Article  PubMed  PubMed Central  Google Scholar 

Wilcox GR, Trudinger BJ, Exner T. The coagulation system in placental insufficiency: a study in the fetal circulation. Br J Obstet Gynaecol. 1993;100:1101–6.

Article  CAS  PubMed  Google Scholar 

Sciascia S, Baldovino S, Schreiber K, Solfietti L, Radin M, Cuadrado MJ, et al. Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay. Clin Mol Allergy. 2016;14:16.

Article  Google Scholar 

Singh A, Nangia A, Sharma S, Puri M. A study of anti beta-2 glycoprotein I and anti-prothrombin antibodies in patients with unexplained recurrent pregnancy losses. Indian J Hematol Blood Transfus. 2016;32:198–201.

Article  PubMed  Google Scholar 

Fatah HR. Association between TORCH infection and lupus anticoagulant antibody in pregnant women with recurrent abortion. Cell Mol Biol (Noisy-le-grand). 2023;69:162–6.

Article  PubMed  Google Scholar 

Bahia W, Zitouni H, Kanabekova P, Bauyrzhanova Z, Shaimardanova M, Finan RR, et al. Human forkhead box protein 3 gene variants associated with altered susceptibility to idiopathic recurrent pregnancy loss: A retrospective case-control study. Am J Reprod Immunol. 2022;88:e13551.

Article  CAS  PubMed  Google Scholar 

Žigon P, Perdan Pirkmajer K, Tomšič M, Kveder T, Božič B, Sodin Šemrl S, et al. Anti-phosphatidylserine/ prothrombin antibodies are associated with adverse pregnancy outcomes. J Immunol Res. 2015;2015:975704.

Comments (0)

No login
gif