Sydora BC, Wilke MS, McPherson M, Chambers S, Ghosh M, Vine DF. Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care. BMC Womens Health. 2023;23:569.

Article  PubMed  PubMed Central  Google Scholar 

Parker M, Warren A, Nair S, Barnard M. Adherence to treatment for polycystic ovarian syndrome: A systematic review. PLoS ONE. 2020;15:e0228586.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melson E, Davitadze M, Malhotra K, group PSw, Mousa A, Teede H, Boivin J, Thondan M, Tay CT, Kempegowda P. A systematic review of models of care for polycystic ovary syndrome highlights the gap in the literature, especially in developing countries. Front Endocrinol (Lausanne). 2023;14:1217468.

Article  PubMed  Google Scholar 

Tan D, Huang Z, Zhao Z, Chen X, Liu J, Wang D, Deng Z, Li W. Single‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review). Int J Mol Med. 2024;53. https://doi.org/10.3892/ijmm.2023.5326.

Wei B, Wang W, Liu X, Xu C, Wang Y, Wang Z, Xu J, Guan J, Zhou P, Mao Y. Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration. Regen Biomater. 2021;8:rbab044.

Article  PubMed  PubMed Central  Google Scholar 

Molnar V, Pavelic E, Vrdoljak K, Cemerin M, Klaric E, Matisic V, Bjelica R, Brlek P, Kovacic I, Tremolada C, Primorac D. Mesenchymal stem cell mechanisms of action and clinical effects in osteoarthritis: a narrative review. Genes (Basel). 2022;13:949.

Article  CAS  PubMed  Google Scholar 

Chen X, Xie W, Zhang M, Shi Y, Xu S, Cheng H, Wu L, Pathak JL, Zheng Z. The emerging role of non-coding rnas in osteogenic differentiation of human bone marrow mesenchymal stem cells. Front Cell Dev Biol. 2022;10:903278.

Article  PubMed  PubMed Central  Google Scholar 

Rezaie J, Feghhi M, Etemadi T. A review on exosomes application in clinical trials: perspective, questions, and challenges. Cell Commun Signal. 2022;20:145.

Article  PubMed  PubMed Central  Google Scholar 

Bhujel B, Shin HE, Choi DJ, Han I. Mesenchymal stem cell-derived exosomes and intervertebral disc regeneration: review. Int J Mol Sci. 2022;23:7306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Posel C, Moller K, Frohlich W, Schulz I, Boltze J, Wagner DC. Density gradient centrifugation compromises bone marrow mononuclear cell yield. PLoS ONE. 2012;7:e50293.

Article  PubMed  PubMed Central  Google Scholar 

Wu H, Zhao B, Yao Q, Kang J. Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes. J Ovarian Res. 2023;16:207.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019;115:1425–34.

Article  CAS  PubMed  Google Scholar 

Ju M, Wang Z, Yang W, Sui Z, Wang W, Sun K, Ren C. Improvement of inflammation and abnormal vascularization by TSP1 treatment combined with ADSCs transplantation in mice with induced polycystic ovary syndrome. Adv Biol (Weinh). 2024;8:e2300451.

Article  PubMed  Google Scholar 

Wang Y, Wang Y, Chen Y, Gao Q, Hou L, Feng X. HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome. Folia Histochem Cytobiol. 2022;60:260–70.

Article  CAS  PubMed  Google Scholar 

Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, et al. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol. 2023;189:G43–64.

Article  PubMed  Google Scholar 

Emanuel RHK, Roberts J, Docherty PD, Lunt H, Campbell RE, Moller K. A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions. Front Endocrinol (Lausanne). 2022;13:1017468.

Article  PubMed  Google Scholar 

Xu Z, Zeng S, Gong Z, Yan Y. Exosome-based immunotherapy: a promising approach for cancer treatment. Mol Cancer. 2020;19:160.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charoenviriyakul C, Takahashi Y, Nishikawa M, Takakura Y. Preservation of exosomes at room temperature using lyophilization. Int J Pharm. 2018;553:1–7.

Article  CAS  PubMed  Google Scholar 

Zhang M, Hu S, Liu L, Dang P, Liu Y, Sun Z, Qiao B, Wang C. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduct Target Ther. 2023;8:124.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Tinney D, Grynyshyn M, Pickering JG, Power A, Dubois L, Hamilton DW. Microcirculation surrounding end-stage human chronic skin wounds is associated with endoglin/CD146/ALK-1 expression, endothelial cell proliferation and an absence of p16(Ink4a). Wound Repair Regen. 2023;31:321–37.

Article  PubMed  Google Scholar 

Slavinsky AA, Verevkin AA. Impaired production of platelet-endothelial cell adhesion molecules as an early diagnostic marker of heart transplant rejection. Arkh Patol. 2022;84:5–10.

Article  CAS  PubMed  Google Scholar 

Guarino B, Katari V, Adapala R, Bhavnani N, Dougherty J, Khan M, Paruchuri S, Thodeti C. Tumor-derived extracellular vesicles induce abnormal angiogenesis via TRPV4 downregulation and subsequent activation of YAP and VEGFR2. Front Bioeng Biotechnol. 2021;9:790489.

Article  PubMed  PubMed Central  Google Scholar 

Kim SM, Yoo JY, Hong YH, Lee J, Kim JH, Lee JR. The effect of growth hormone on ovarian function recovery in a mouse model of ovarian insufficiency. Front Endocrinol (Lausanne). 2023;14:1184977.

Article  PubMed  Google Scholar 

Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R, Meczekalski B. Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci. 2021;22:3789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park HS, Cetin E, Siblini H, Seok J, Alkelani H, Alkhrait S, Liakath Ali F, Mousaei Ghasroldasht M, Beckman A, Al-Hendy A. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles to treat PCOS. Int J Mol Sci. 2023;24:11151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim M, Thompson JG, Dunning KR. Hypoxia and reproductive health: Hypoxia and ovarian function: follicle development, ovulation, oocyte maturation. Reproduction. 2021;161:F33–40.

Article  CAS  PubMed  Google Scholar 

Vasyukova E, Zaikova E, Kalinina O, Gorelova I, Pyanova I, Bogatyreva E, Vasilieva E, Grineva E, Popova P. Inflammatory and anti-inflammatory parameters in PCOS patients depending on body mass index: a case-control study. Biomedicines. 2023;11:2791.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akpata CBN, Uadia PO, Okonofua FE. Association between C-reactive protein and low-grade inflammation among Nigerian women with polycystic ovarian syndrome. West Afr J Med. 2023;40:1079–85.

CAS  PubMed  Google Scholar 

Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F. Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women. BMC Womens Health. 2023;23:68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elbandrawy AM, Yousef AM, Morgan EN, Ewais NF, Eid MM, Elkholi SM, Abdelbasset WK. Effect of aerobic exercise on inflammatory markers in polycystic ovary syndrome: a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2022;26:3506–13.

CAS  PubMed  Google Scholar