Roett MA, Evans P. Ovarian cancer: an overview. Am Fam Physician. 2009;80:609–16.

PubMed  Google Scholar 

Cho KR, Shih Ie M. Ovarian cancer. Annu Rev Pathol. 2009;4:287–313. https://doi.org/10.1146/annurev.pathol.4.110807.092246.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Tian B, Liu M, Miao C, Wang D. Adult-type granulosa cell tumor of the ovary. Am J Cancer Res. 2022;12:3495–511.

CAS  PubMed  PubMed Central  Google Scholar 

Levin G, Zigron R, Haj-Yahya R, Matan LS, Rottenstreich A. Granulosa cell tumor of ovary: A systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol. 2018;225:57–61. https://doi.org/10.1016/j.ejogrb.2018.04.002.

Article  PubMed  Google Scholar 

Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol. 2003;21:1180–9. https://doi.org/10.1200/JCO.2003.10.019.

Article  PubMed  Google Scholar 

Patel SS, Carrick KS, Carr BR. Virilization persists in a woman with an androgen-secreting granulosa cell tumor. Fertil Steril. 2009;91(933):e913-935. https://doi.org/10.1016/j.fertnstert.2008.10.038.

Article  Google Scholar 

Minlikeeva AN, Freudenheim JL, Cannioto RA, Eng KH, Szender JB, Mayor P, Etter JL, Cramer DW, Diergaarde B, Doherty JA, et al. History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report. Br J Cancer. 2017;117:1063–9. https://doi.org/10.1038/bjc.2017.267.

Article  PubMed  PubMed Central  Google Scholar 

Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122:3035–43. https://doi.org/10.1172/JCI60047.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu YC, Yeh CT, Lin KH. Molecular functions of thyroid hormone signaling in regulation of cancer progression and anti-apoptosis. Int J Mol Sci. 2019;20:4986. https://doi.org/10.3390/ijms20204986.

Article  CAS  PubMed  PubMed Central  Google Scholar 

PetranovicOvcaricek P, Verburg FA, Hoffmann M, Iakovou I, Mihailovic J, Vrachimis A, Luster M, Giovanella L. Higher thyroid hormone levels and cancer. Eur J Nucl Med Mol Imaging. 2021;48:808–21. https://doi.org/10.1007/s00259-020-05018-z.

Article  CAS  Google Scholar 

Hsieh MT, Wang LM, Changou CA, Chin YT, Yang YSH, Lai HY, Lee SY, Yang YN, Whang-Peng J, Liu LF, et al. Crosstalk between integrin alphavbeta3 and ERalpha contributes to thyroid hormone-induced proliferation of ovarian cancer cells. Oncotarget. 2017;8:24237–49. https://doi.org/10.18632/oncotarget.10757.

Article  PubMed  Google Scholar 

Hassan MM, Kaseb A, Li D, Patt YZ, Vauthey JN, Thomas MB, Curley SA, Spitz MR, Sherman SI, Abdalla EK, et al. Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States. Hepatology. 2009;49:1563–70. https://doi.org/10.1002/hep.22793.

Article  PubMed  Google Scholar 

Wang Y, Zhou R, Wang J. Relationship between hypothyroidism and endometrial cancer. Aging Dis. 2019;10:190–6. https://doi.org/10.14336/AD.2018.0224.

Article  PubMed  PubMed Central  Google Scholar 

Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R, Wheeler JE, Morgan M, Schlesselman JJ. Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer. Epidemiology. 2000;11:111–7. https://doi.org/10.1097/00001648-200003000-00006.

Article  CAS  PubMed  Google Scholar 

Journy NMY, Bernier MO, Doody MM, Alexander BH, Linet MS, Kitahara CM. Hyperthyroidism, hypothyroidism, and cause-specific mortality in a large cohort of women. Thyroid. 2017;27:1001–10. https://doi.org/10.1089/thy.2017.0063.

Article  PubMed  PubMed Central  Google Scholar 

Gauthier BR, Sola-Garcia A, Caliz-Molina MA, Lorenzo PI, Cobo-Vuilleumier N, Capilla-Gonzalez V, Martin-Montalvo A. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 2020;19: e13260. https://doi.org/10.1111/acel.13260.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plateroti M, Kress E, Mori JI, Samarut J. Thyroid hormone receptor alpha1 directly controls transcription of the beta-catenin gene in intestinal epithelial cells. Mol Cell Biol. 2006;26:3204–14. https://doi.org/10.1128/MCB.26.8.3204-3214.2006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conde I, Paniagua R, Zamora J, Blánquez MJ, Fraile B, Ruiz A, Arenas MI. Influence of thyroid hormone receptors on breast cancer cell proliferation. Ann Oncol. 2006;17:60–4.

Article  CAS  PubMed  Google Scholar 

Zou S, Tong Q, Liu B, Huang W, Tian Y, Fu X. Targeting STAT3 in Cancer Immunotherapy. Mol Cancer. 2020;19:145. https://doi.org/10.1186/s12943-020-01258-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022;52:102317. https://doi.org/10.1016/j.redox.2022.102317.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sgrignani J, Garofalo M, Matkovic M, Merulla J, Catapano CV, Cavalli A. Structural biology of STAT3 and its implications for anticancer therapies development. Int J Mol Sci. 2018;19:1591. https://doi.org/10.3390/ijms19061591.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y, Zhu X. STAT3 signaling in ovarian cancer: a potential therapeutic target. J Cancer. 2020;11:837–48. https://doi.org/10.7150/jca.35011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang B, Lang X, Li X. The role of IL-6/JAK2/STAT3 signaling pathway in cancers. Front Oncol. 2022;12:1023177. https://doi.org/10.3389/fonc.2022.1023177.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silver DL, Naora H, Liu J, Cheng W, Montell DJ. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res. 2004;64:3550–8. https://doi.org/10.1158/0008-5472.CAN-03-3959.

Article  CAS  PubMed  Google Scholar 

Bixel K, Saini U, Kumar Bid H, Fowler J, Riley M, Wanner R, Deepa PriyaDorayappan K, Rajendran S, Konishi I, Matsumura N, et al. Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma. Int J Cancer. 2017;141:1856–66. https://doi.org/10.1002/ijc.30847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin HY, Shih A, Davis FB, Davis PJ. Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells. Biochem J. 1999;338(Pt 2):427–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Zhou Z, Zhong M, Li M, Yang X, Zhang Y, Wang Y, Wei A, Qu M, Zhang L, et al. Excess thyroid hormone inhibits embryonic neural stem/progenitor cells proliferation and maintenance through STAT3 signalling pathway. Neurotox Res. 2011;20:15–25. https://doi.org/10.1007/s12640-010-9214-y.

Article  CAS  PubMed  Google Scholar 

Wang Q, Yao Y, Ma X, Fu B, Li N, Zhang C. Mechanisms of OCT4 on 3,5,3’-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice. Endocrinology. 2021;162:bqab183. https://doi.org/10.1210/endocr/bqab183.

Article  CA