The relationship between sphingomyelin and ceramide levels and soft neurological signs in ADHD

Adhvaryu KP, Karthikbabu S, Rao PTJC, Pediatrics E (2022) Motor performance of children with attention deficit hyperactivity disorder: focus on the Bruininks-Oseretsky Test of Motor Proficiency. 65:512

Ahn KH, Kim SK, Choi JM, Jung SY, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Kim DK (2013) Identification of heat shock protein 60 as a Regulator of Neutral Sphingomyelinase 2 and its role in dopamine uptake. PLoS ONE 8:e67216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ariga T, Jarvis WD, Yu RK (1998) Role of sphingolipid-mediated cell death in neurodegenerative diseases. J Lipid Res 39:1–16

Article  CAS  PubMed  Google Scholar 

Austerman J (2015) ADHD and behavioral disorders: Assessment, management, and an update from DSM-5. Cleve Clin J Med 82:S2–7

Article  PubMed  Google Scholar 

Barrier L, Page G, Barc S, Piriou A, Portoukalian J (2003) Sulfatide and GM1 Ganglioside modulate the high-affinity dopamine uptake in rat striatal synaptosomes: evidence for the involvement of their ionic charges. Neurochem Int 42:305–313

Article  CAS  PubMed  Google Scholar 

Ben-David O, Futerman AH (2010) The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromol Med 12:341–350

Article  CAS  Google Scholar 

Bradbury AM, Bongarzone ER, Sands MS (2021) Krabbe disease: New hope for an old disease. Neurosci Lett 752:135841

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brunkhorst-Kanaan N, Trautmann S, Schreiber Y, Thomas D, Kittel-Schneider S, Gurke R, Geisslinger G, Reif A, Tegeder IJB (2021a) Sphingolipid and endocannabinoid profiles in adult attention deficit hyperactivity disorder. 9:1173

Brunkhorst-Kanaan N, Trautmann S, Schreiber Y, Thomas D, Kittel-Schneider S, Gurke R, Geisslinger G, Reif A, Tegeder I (2021b) Sphingolipid and endocannabinoid profiles in adult attention deficit hyperactivity disorder. Biomedicines 9

Buccinnà B, Piccinini M, Prinetti A, Scandroglio F, Prioni S, Valsecchi M, Votta B, Grifoni S, Lupino E, Ramondetti C et al (2009) Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann-pick disease type A. J Neurochem 109:105–115

Article  PubMed  Google Scholar 

Cho S-C, Kim H-W, Kim B-N, Kim J-W, Shin M-S, Chung S, Cho D-Y, Jung S-W, Yoo HJ (2010) Chung I-WJPi: gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder. 7:285

Cole W, Mostofsky S, Larson JG, Denckla M, Mahone EJN (2008) Age-related changes in motor subtle signs among girls and boys with ADHD. 71:1514–1520

Copeland B, Vogelsberg V, Neff N, Hadjiconstantinou MJJP, Therapeutics E (1996) Protein kinase C activators decrease dopamine uptake into striatal synaptosomes. 277:1527–1532

Crasta JE, Zhao Y, Seymour KE, Suskauer SJ, Mostofsky SH, Rosch KSJCN (2021) Developmental trajectory of subtle motor signs in attention-deficit/hyperactivity disorder: a longitudinal study from childhood to adolescence. 27:317–332

da Silva BS, Grevet EH, Silva LCF, Ramos JKN, Rovaris DL, Bau CHDJD (2023) Discover Mental Health 3:2

Article  PubMed  PubMed Central  Google Scholar 

Darwish AH, Elgohary TM, Nosair NA (2019) Serum Interleukin-6 level in children with attention-deficit hyperactivity disorder (ADHD). J Child Neurol 34:61–67

Article  PubMed  Google Scholar 

de Wit NM, den Hoedt S, Martinez-Martinez P, Rozemuller AJ, Mulder MT, de Vries HE (2019) Astrocytic ceramide as possible indicator of neuroinflammation. J Neuroinflamm 16:48

Article  Google Scholar 

Detrick JA, Zink C, Rosch KS, Horn PS, Huddleston DA, Crocetti D, Wu SW, Pedapati EV, Wassermann EM, Mostofsky SHJBC (2021) Motor cortex modulation and reward in children with attention-deficit/hyperactivity disorder. 3:fcab093

Drechsler R, Brem S, Brandeis D, Grünblatt E, Berger G, Walitza SJN (2020) ADHD: current concepts and treatments in children and adolescents. 51:315–335

El Ghamry R, El-Sheikh M, Abdel Meguid M, Nagib S (2021) Aly El Gabry DJMECP: plasma brain-derived neurotrophic factor (BDNF) in Egyptian children with attention deficit hyperactivity disorder. 28:1–9

Ercan E, Amado S, Somer O (2001) Çıkoğlu SJÇvGRSD: Dikkat eksikliği hiperaktivite bozukluğu ve yıkıcı davranım bozuklukları için bir test bataryası geliştirme çabası. 8:132–144

Faltraco F, Palm D, Uzoni A, Borchert L, Simon F, Tucha O, Thome J (1996) Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients. Journal of neural transmission (Vienna, Austria: 2021, 128:1135–1145

Fliers E, Rommelse N, Vermeulen S, Altink M, Buschgens C, Faraone S, Sergeant J, Franke B (2008) Buitelaar JJJont: Motor coordination problems in children and adolescents with ADHD rated by parents and teachers: effects of age and gender. 115:211–220

Franke B, Michelini G, Asherson P, Banaschewski T, Bilbow A, Buitelaar JK, Cormand B, Faraone SV, Ginsberg Y, Haavik J et al (2018) Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan. Eur Neuropsychopharmacology: J Eur Coll Neuropsychopharmacol 28:1059–1088

Article  CAS  Google Scholar 

Gokler BJTJCAMH (2004) Reliability and validity of schedule for affective disorders and Schizophrenia for school age children-present and lifetime version-turkish version (K-SADS-PL-T)[in Turkish]. 11:109–116

Güleç A, Güler HA, Türkoğlu SJCI (2024) Relationship between traumatic experiences, circadian preference and ADHD symptoms in adolescents with ADHD residing in Institutional Care: a controlled study.:1–9

Han X, Rozen S, Boyle SH, Hellegers C, Cheng H, Burke JR, Welsh-Bohmer KA, Doraiswamy PM, Kaddurah-Daouk R (2011) Metabolomics in early Alzheimer’s disease: identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS ONE 6:e21643

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haughey NJ, Bandaru VV, Bae M, Mattson MP (2010) Roles for dysfunctional sphingolipid metabolism in Alzheimer’s disease neuropathogenesis. Biochim Biophys Acta 1801:878–886

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henriquez-Henriquez M, Acosta MT, Martinez AF, Vélez JI, Lopera F, Pineda D, Palacio JD, Quiroga T, Worgall TS (2020a) Deckelbaum RJJTp: mutations in sphingolipid metabolism genes are associated with ADHD. 10:231

Henriquez-Henriquez M, Acosta MT, Martinez AF, Vélez JI, Lopera F, Pineda D, Palacio JD, Quiroga T, Worgall TS, Deckelbaum RJ et al (2020b) Mutations in sphingolipid metabolism genes are associated with ADHD. Translational Psychiatry 10:231

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henríquez-Henríquez MP, Solari S, Quiroga T, Kim BI, Deckelbaum RJ (2015) Worgall TSJFin: low serum sphingolipids in children with attention deficit-hyperactivity disorder. 9:300

Hess JL, Radonjić NV, Patak J, Glatt SJ, Faraone SV (2021) Autophagy, apoptosis, and neurodevelopmental genes might underlie selective brain region vulnerability in attention-deficit/hyperactivity disorder. Mol Psychiatry 26:6643–6654

Article  CAS  PubMed  Google Scholar 

Iacono S, Del Giudice E, Leon A, La Bella V, Spataro R (2022) A novel compound heterozygous mutation in GALC associated with adult-onset Krabbe disease: case report and literature review. Neurogenetics 23:157–165

Article  CAS  PubMed  Google Scholar 

Ishii T, Warabi E, Mann GE (2019) Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis. Free Radic Biol Med 133:169–178

Article  CAS  PubMed  Google Scholar 

Jové M, Cabré R, Mota-Martorell N, Martin-Garí M, Obis È, Ramos P, Canales I, Galo-Licona JD, Sol J, Nogueras L et al (2021) Age-related changes in Lipidome of Rat Frontal Cortex and Cerebellum are partially reversed by Methionine Restriction Applied in Old Age. Int J Mol Sci 22

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan NJJotAAoC, Psychiatry A (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. 36:980–988

Kharitonova M, Martin RE, Gabrieli JD, Sheridan MAJD (2013) Cortical gray-matter thinning is associated with age-related improvements on executive function tasks. 6:61–71

Kuperberg SJ, Wadgaonkar R (2017) Sepsis-Associated Encephalopathy: the blood-brain barrier and the Sphingolipid Rheostat. Front Immunol 8:597

Article  PubMed  PubMed Central  Google Scholar 

Leffa DT, Bellaver B, de Oliveira C, de Macedo IC, de Freitas JS, Grevet EH, Caumo W, Rohde LA, Quincozes-Santos A, Torres ILS (2017) Increased oxidative parameters and decreased cytokine levels in an animal model of Attention-Deficit/Hyperactivity disorder. Neurochem Res 42:3084–3092

Article  CAS  PubMed  Google Scholar 

Lequin RM (2005) Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin Chem 51:2415–2418

Article  CAS  PubMed  Google Scholar 

Lintas C, Cassano I, Azzarà A, Stigliano MG, Gregorj C, Sacco R, Stoccoro A, Coppedè F, Gurrieri FJG (2023) Maternal epigenetic dysregulation as a possible risk factor for neurodevelopmental disorders. 14:585

Loft LM, Moseholm KF, Pedersen KK, Jensen MK, Koch M (2022) Cronje HTJCOiL: sphingomyelins and ceramides: possible biomarkers for dementia? 33:57–67

Marian OC, Teo JD, Lee JY, Song H, Kwok JB, Landin-Romero R, Halliday G, Don AS (2023) Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations. Acta Neuropathol Commun 11:52

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marín T, Dulcey AE, Campos F, de la Fuente C, Acuña M, Castro J, Pinto C, Yañez MJ, Cortez C, McGrath DW et al (2022) c-Abl activation linked to autophagy-lysosomal dysfunction contributes to neurological impairment in Niemann-pick type a Disease. Front cell Dev Biology 10:844297

Article  Google Scholar 

Marks N, Berg MJ, Saito M, Saito M (2008) Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons. Brain Res 1191:136–147

Article  CAS  PubMed  Google Scholar 

Martins IP, Lauterbach M, Luís H, Amaral H, Rosenbaum G, Slade PD, Townes BDJCN (2013) Neurological subtle signs and cognitive development: a study in late childhood and adolescence. 19:466–478

Mielke MM, Maetzler W, Haughey NJ, Bandaru VV, Savica R, Deuschle C, Gasser T, Hauser AK, Gräber-Sultan S, Schleicher E et al (2013) Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson’s disease and associated with cognitive impairment: a pilot study. PLoS ONE 8:e73094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mondal K, Del Mar NA, Gary AA, Grambergs RC, Yousuf M, Tahia F, Stephenson B, Stephenson DJ, Chalfant CE, Reiner A, Mandal N (2024) Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases. Lipids Health Dis 23:200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mostofsky M SH, Newschaffer CJ, Denckla MBJP, skills (2003) Overflow movements predict impaired response inhibition in children with ADHD. 97:1315–1331

Nagel BJ, Bathula D, Herting M, Schmitt C, Kroenke CD, Fair D (2011) Nigg JTJJotAAoC, Psychiatry A: altered white matter microstructure in children with attention-deficit/hyperactivity disorder. 50:283–292

Nakajima K, Tohyama Y, Kohsaka S, Kurihara TJJ (2002) Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro. 80:697–705

Notaras M, van den Buuse MJTN (2019) Brain-derived neurotrophic factor (BDNF): novel insights into regulation and genetic variation. 25:434–454

Oizumi H, Sugimura Y, Totsune T, Kawasaki I, Ohshiro S, Baba T, Kimpara T, Sakuma H, Hasegawa T, Kawahata I et al (2022) Plasma sphingolipid abnormalities in neurodegenerative diseases. PLoS ONE 17:e0279315

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