Developing Cut-off Values for Low and Very Low Bone Mineral Density at the Thoracic Spine Using Quantitative Computed Tomography

Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporosis Int 17:1726–1733

Article  CAS  Google Scholar 

Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195–202

Article  CAS  PubMed  Google Scholar 

LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, Siris ES (2022) The clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis Int 33:2049–2102

Article  CAS  Google Scholar 

Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R (2014) Clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis Int 25:2359–2381

Article  CAS  Google Scholar 

Ott SM, O'Hanlan M, Lipkin EW, Newell-Morris L (1997) Evaluation of vertebral volumetric vs. areal bone mineral density during growth. Bone 20:553–556.

Link TM (2012) Osteoporosis imaging: state of the art and advanced imaging. Radiology 263:3–17

Article  PubMed  PubMed Central  Google Scholar 

Engelke K (2017) Quantitative computed tomography-current status and new developments. J Clin Densitom 20:309–321. https://doi.org/10.1016/j.jocd.2017.1006.1017.

Liu G, Peacock M, Eilam O, Dorulla G, Braunstein E, Johnston CC (1997) Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women. Osteoporosis Int 7:564–569

Article  CAS  Google Scholar 

Lin W, He C, Xie F, Chen T, Zheng G, Yin H, Chen H, Wang Z (2023) Quantitative CT screening improved lumbar BMD evaluation in older patients compared to dual-energy X-ray absorptiometry. BMC Geriatr 23:231

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown JK, Timm W, Bodeen G, Chason A, Perry M, Vernacchia F, DeJournett R (2017) Asynchronously calibrated quantitative bone densitometry. J Clin Densitom 20:216–225

Article  CAS  PubMed  Google Scholar 

Lenchik L, Weaver AA, Ward RJ, Boone JM, Boutin RD (2018) Opportunistic screening for osteoporosis using computed tomography: state of the art and argument for paradigm shift. Curr Rheumatol Rep 20:74

Article  PubMed  PubMed Central  Google Scholar 

Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM (2008), Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions. J Clin Densitom 11(2008):123–162. https://doi.org/10.1016/j.jocd.2007.1012.1010

Article  Google Scholar 

Adams JE (2013) Advances in bone imaging for osteoporosis, nature reviews. Endocrinology 9:28–42

CAS  PubMed  Google Scholar 

A.C.o. Radiology, ACR–SPR–SSR Practice parameter for the performance of musculoskeletal quantitative computed tomographY (QCT), Revised 2018 (Resolution 9), (2018) 14.

Budoff MJ, Hamirani YS, Gao YL, Ismaeel H, Flores FR, Child J, Carson S, Nee JN, Mao S (2010) Measurement of thoracic bone mineral density with quantitative CT. Radiology 257:434–440

Article  PubMed  Google Scholar 

Budoff MJ, Khairallah W, Li D, Gao YL, Ismaeel H, Flores F, Child J, Carson S, Mao SS (2012) Trabecular bone mineral density measurement using thoracic and lumbar quantitative computed tomography. Acad Radiol 19:179–183

Article  PubMed  Google Scholar 

Wong M, Papa A, Lang T, Hodis HN, Labree L, Detrano R (2005) Validation of thoracic quantitative computed tomography as a method to measure bone mineral density. Calcif Tissue Int 76:7–10

CAS  PubMed  Google Scholar 

Therkildsen J, Winther S, Nissen L, Jørgensen H, Thygesen J, Ivarsen P, Frost L, Langdahl B, Hauge E, Bøttcher M (2018) Feasibility of opportunistic screening for low thoracic bone mineral density in patients referred for routine cardiac CT. J Clin Densitom, p 23.

Therkildsen J, Nissen L, Jørgensen HS, Thygesen J, Ivarsen P, Frost L, Isaksen C, Langdahl BL, Hauge EM, Boettcher M, Winther S (2020) Thoracic bone mineral density derived from cardiac CT is associated with greater fracture rate. Radiology 296:499–508

Article  PubMed  Google Scholar 

Rasmussen LD, Fordyce CB, Nissen L, Hill CL Jr, Alhanti B, Hoffmann U, Udelson J, Bøttcher M, Douglas PS, Winther S (2022) The PROMISE minimal risk score improves risk classification of symptomatic patients with suspected CAD, JACC. Cardiovascular Imag 15:1442–1454

Google Scholar 

Rasmussen LD, Winther S, Westra J, Isaksen C, Ejlersen JA, Brix L, Kirk J, Urbonaviciene G, Søndergaard HM, Hammid O, Schmidt SE, Knudsen LL, Madsen LH, Frost L, Petersen SE, Gormsen LC, Christiansen EH, Eftekhari A, Holm NR, Nyegaard M, Chiribiri A, Bøtker HE, Böttcher M (2019) Danish study of non-invasive testing in Coronary Artery Disease 2 (Dan-NICAD 2): study design for a controlled study of diagnostic accuracy. Am Heart J 215:114–128

Article  PubMed  Google Scholar 

Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148

Article  CAS  PubMed  Google Scholar 

Mao SS, Li D, Syed YS, Gao Y, Luo Y, Flores F, Child J, Cervantes M, Kalantar-Zadeh K, Budoff MJ (2017) Thoracic Quantitative Computed Tomography (QCT) can sensitively monitor bone mineral metabolism: comparison of thoracic QCT vs lumbar QCT and dual-energy X-ray absorptiometry in detection of age-relative change in bone mineral density. Acad Radiol 24:1582–1587

Article  PubMed  Google Scholar 

Szulc P (2016) Abdominal aortic calcification: a reappraisal of epidemiological and pathophysiological data. Bone 84:25–37

Article  CAS  PubMed  Google Scholar 

Li D, Mao SS, Khazai B, Hyder JA, Allison M, McClelland R, de Boer I, Carr JJ, Criqui MH, Gao Y, Budoff MJ (2013) Noncontrast cardiac computed tomography image-based vertebral bone mineral density: the multi-ethnic study of atherosclerosis (MESA). Acad Radiol 20:621–627

Article  PubMed  PubMed Central  Google Scholar 

Khosla S, Melton LJ 3rd, Riggs BL (2011) The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res 26:441–451

Article  CAS  PubMed  Google Scholar 

Forwood MR (2001) Mechanical effects on the skeleton: are there clinical implications? Osteoporosis Int 12:77–83

Article  CAS  Google Scholar 

Ettinger B, Genant HK, Cann CE (1987) Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 106:40–45

Article  CAS  PubMed  Google Scholar 

Yu W, Qin M, Xu L, van Kuijk C, Meng X, Xing X, Cao J, Genant HK (1999) Normal changes in spinal bone mineral density in a Chinese population: assessment by quantitative computed tomography and dual-energy X-ray absorptiometry. Osteoporosis Int 9:179–187

Article  CAS  Google Scholar 

Carr JJ, Register TC, Hsu FC, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Rich SS, Wagenknecht LE, Freedman BI (2008) Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study. Bone 42:43–52

Article  CAS  PubMed  Google Scholar 

Bruno AG, Broe KE, Zhang X, Samelson EJ, Meng CA, Manoharan R, D’Agostino J, Cupples LA, Kiel DP, Bouxsein ML (2014) Vertebral size, bone density, and strength in men and women matched for age and areal spine BMD. J Bone Mineral Res 29:562–569

Article  Google Scholar 

Buenger F, Eckardt N, Sakr Y, Senft C, Schwarz F (2021) Correlation of bone density values of quantitative computed tomography and hounsfield units measured in native computed tomography in 902 vertebral bodies. World Neurosurg 151:e599–e606

Article  PubMed  Google Scholar 

Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Shousboe JT (2015) Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III. J Clin Densitom 18:393–407

Article  PubMed  Google Scholar 

Bauer JS, Henning TD, Müeller D, Lu Y, Majumdar S, Link TM (2007) Volumetric quantitative CT of the spine and hip derived from contrast-enhanced MDCT: conversion factors. AJR Am J Roentgenol 188:1294–1301

Article  PubMed  Google Scholar 

Cheneymann A, Therkildsen J, Winther S, Nissen L, Thygesen J, Langdahl BL, Hauge EM, Bøttcher M (2024) Bone mineral density derived from cardiac CT scans: using contrast enhanced scans for opportunistic screening. J Clin Densitom 27:101441

Article  PubMed  Google Scholar 

Yu L, Liu X, Leng S, Kofler JM, Ramirez-Giraldo JC, Qu M, Christner J, Fletcher JG, McCollough CH (2009) Radiation dose reduction in computed tomography: techniques and future perspective. Imaging Med 1:65–84

Article  PubMed  PubMed Central 

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