Positron Emission Tomography in the Diagnosis and Management of Cardiac Allograft Vasculopathy

Ramzy D, Rao V, Brahm J, Miriuka S, Delgado D, Ross HJ. Cardiac allograft vasculopathy: a review. Can J Surg. 2005;48:319–27.

PubMed  PubMed Central  Google Scholar 

Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovasc Res. 2021;117:2624–38. https://doi.org/10.1093/cvr/cvab259.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weis M, von Scheidt W. Cardiac allograft vasculopathy: a review. Circulation. 1997;96:2069–77. https://doi.org/10.1161/01.cir.96.6.2069.

Article  CAS  PubMed  Google Scholar 

Lund LH, Edwards LB, Kucheryavaya AY, et al. The registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Heart Transplantation Report–2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34:1244–54. https://doi.org/10.1016/j.healun.2015.08.003.

Article  PubMed  Google Scholar 

Velleca A, Shullo MA, Dhital K, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023;42:e1–141. https://doi.org/10.1016/j.healun.2022.10.015.

Article  PubMed  Google Scholar 

Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, Madsen J, Parameshwar J, Starling RC, Uber PA. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant. 2010;29:717–27. https://doi.org/10.1016/j.healun.2010.05.017.

Article  PubMed  Google Scholar 

Wu Y-W, Chen Y-H, Wang S-S, Jui H-Y, Yen R-F, Tzen K-Y, Chen M-F, Lee C-M. PET assessment of myocardial perfusion reserve inversely correlates with intravascular ultrasound findings in angiographically normal cardiac transplant recipients. J Nucl Med. 2010;51:906–12. https://doi.org/10.2967/jnumed.109.073833.

Article  PubMed  Google Scholar 

Terashima M, Kaneda H, Suzuki T. The role of optical coherence tomography in coronary intervention. Korean J Intern Med. 2012;27:1–12. https://doi.org/10.3904/kjim.2012.27.1.1.

Article  PubMed  PubMed Central  Google Scholar 

Ahn J-M, Zimmermann FM, Arora S, et al. Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation. Eur Heart J. 2021;42:4918–29. https://doi.org/10.1093/eurheartj/ehab568.

Article  PubMed  PubMed Central  Google Scholar 

Lee JM, Choi KH, Choi J-O, et al. Coronary microcirculatory dysfunction and acute cellular rejection after heart transplantation. Circulation. 2021;144:1459–72. https://doi.org/10.1161/CIRCULATIONAHA.121.056158.

Article  CAS  PubMed  Google Scholar 

Konerman MC, Lazarus JJ, Weinberg RL, et al. Reduced myocardial flow reserve by positron emission tomography predicts cardiovascular events after cardiac transplantation. Circ Heart Fail. 2018;11:e004473. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004473.

Article  PubMed  PubMed Central  Google Scholar 

Miller RJH, Manabe O, Tamarappoo B, Hayes S, Friedman JD, Slomka PJ, Patel J, Kobashigawa JA, Berman DS. Comparative prognostic and diagnostic value of myocardial blood flow and myocardial flow reserve after cardiac transplantation. J Nucl Med. 2020;61:249–55. https://doi.org/10.2967/jnumed.119.229625.

Article  CAS  PubMed  Google Scholar 

Chih S, Chong AY, Mielniczuk LM, Bhatt DL, Beanlands RSB. Allograft vasculopathy: the Achilles’ heel of heart transplantation. J Am Coll Cardiol. 2016;68:80–91. https://doi.org/10.1016/j.jacc.2016.04.033.

Article  PubMed  Google Scholar 

Bravo PE, Bergmark BA, Vita T, et al. Diagnostic and prognostic value of myocardial blood flow quantification as non-invasive indicator of cardiac allograft vasculopathy. Eur Heart J. 2018;39:316–23. https://doi.org/10.1093/eurheartj/ehx683.

Article  CAS  PubMed  Google Scholar 

Abadie BQ, Chan N, Sharalaya Z, Bhat P, Harb S, Jacob M, Starling RC, Tang WHW, Cremer PC, Jaber WA. Negative predictive value and prognostic associations of Rb-82 PET/CT with myocardial blood flow in CAV. JACC Heart Fail. 2023;11:555–65. https://doi.org/10.1016/j.jchf.2022.11.012.

Article  PubMed  Google Scholar 

Clerkin KJ, Topkara VK, Farr MA, et al. Noninvasive physiologic assessment of cardiac allograft vasculopathy is prognostic for post-transplant events. J Am Coll Cardiol. 2022;80:1617–28. https://doi.org/10.1016/j.jacc.2022.08.751.

Article  PubMed  PubMed Central  Google Scholar 

Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu Y-H, Lee F, Sinusas AJ. Serial assessment of coronary flow reserve by rubidium-82 positron emission tomography predicts mortality in heart transplant recipients. JACC Cardiovasc Imaging. 2020;13:109–20. https://doi.org/10.1016/j.jcmg.2018.08.025.

Article  PubMed  Google Scholar 

Wiefels C, Almufleh A, Yao J, deKemp RA, Chong A-Y, Mielniczuk LM, Stadnick E, Davies RA, Beanlands RS, Chih S. Prognostic utility of longitudinal quantification of PET myocardial blood flow early post heart transplantation. J Nucl Cardiol. 2022;29:712–23. https://doi.org/10.1007/s12350-020-02342-7.

Article  PubMed  Google Scholar 

Gondi KT, Hammer Y, Yosef M, Golbus JR, Madamanchi C, Aaronson KD, Murthy VL, Konerman MC. Longitudinal change and predictors of myocardial flow reserve by positron emission tomography for the evaluation of cardiac allograft vasculopathy following heart transplantation. J Card Fail. 2023;S1071–9164(23):00377–9. https://doi.org/10.1016/j.cardfail.2023.09.013.

Article  Google Scholar 

Abadie B, Albert C, Bhat P, Harb S, Jacob M, Starling RC, Tang WHW, Jaber WA. Frequency of screening for cardiac allograft vasculopathy: warranty period of initial low risk positron emission tomography. Eur Heart J Cardiovasc Imaging. 2024;25:814–20. https://doi.org/10.1093/ehjci/jeae015.

Article  PubMed  Google Scholar 

Gondi KT, Kaul DR, Gregg KS, Golbus JR, Aaronson KD, Murthy VL, Konerman MC. Cytomegalovirus infection is associated with impaired myocardial flow reserve after heart transplantation. J Heart Lung Transplant. 2024;43:432–41. https://doi.org/10.1016/j.healun.2023.10.005.

Article  PubMed  Google Scholar 

Nikolova A, Agbor-Enoh S, Bos S, Crespo-Leiro M, Ensminger S, Jimenez-Blanco M, Minervini A, Perch M, Segovia J, Vos R, Khush K. European Society for Organ Transplantation (ESOT) consensus statement on the use of non-invasive biomarkers for cardiothoracic transplant rejection surveillance. Trans Int. 2024;37:12445. https://doi.org/10.3389/ti.2024.12445.

Crespo-Leiro MG, Zuckermann A, Bara C, et al. Concordance among pathologists in the second cardiac allograft rejection gene expression observational study (CARGO II). Transplantation. 2012;94:1172–7. https://doi.org/10.1097/TP.0b013e31826e19e2.

Article  PubMed  Google Scholar 

Patterson RE, Eisner RL, Horowitz SF. Comparison of cost-effectiveness and utility of exercise ECG, single photon emission computed tomography, positron emission tomography, and coronary angiography for diagnosis of coronary artery disease. Circulation. 1995;91:54–65. https://doi.org/10.1161/01.cir.91.1.54.

Article  CAS  PubMed  Google Scholar 

Chen K, Miller EJ, Sadeghi MM. PET-based imaging of ischemic heart disease. PET Clin. 2019;14:211–21. https://doi.org/10.1016/j.cpet.2018.12.003.

Article  PubMed  PubMed Central  Google Scholar 

Merhige ME, Breen WJ, Shelton V, Houston T, D’Arcy BJ, Perna AF. Impact of myocardial perfusion imaging with PET and (82)Rb on downstream invasive procedure utilization, costs, and outcomes in coronary disease management. J Nucl Med. 2007;48:1069–76. https://doi.org/10.2967/jnumed.106.038323.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif