Orexin and Sleep Disturbances in Alpha-Synucleinopathies: a Systematic Review

Dorsey ER, Sherer T, Okun MS, Bloem BR. The emerging evidence of the Parkinson pandemic. J Parkinsons Dis. 2018;8:S3–8.

Article  PubMed  PubMed Central  Google Scholar 

Calabresi P, Mechelli A, Natale G, Volpicelli-Daley L, Di Lazzaro G, Ghiglieri V. Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction. Cell Death Dis. 2023;14:176.

Article  PubMed  PubMed Central  Google Scholar 

Spillantini MG, Schmidt ML, Lee VM-Y, Trojanowski JQ, Jakes R, Goedert M. α-Synuclein in Lewy bodies. Nature. 1997;388:839–40.

Article  CAS  PubMed  Google Scholar 

McCann H, Stevens CH, Cartwright H, Halliday GM. α-Synucleinopathy phenotypes. Parkinsonism Relat Disord. 2014;20:S62–7.

Article  PubMed  Google Scholar 

Malfertheiner K, Stefanova N, Heras-Garvin A. The concept of α-Synuclein strains and how different conformations may explain distinct neurodegenerative disorders. Front Neurol. 2021;12:737195.

Article  PubMed  PubMed Central  Google Scholar 

Beyer K, Ariza A. Protein aggregation mechanisms in synucleinopathies: commonalities and differences. J Neuropathol Exp Neurol. 2007;66:965–74.

Article  CAS  PubMed  Google Scholar 

Drakatos P, Olaithe M, Verma D, Ilic K, Cash D, Fatima Y, Higgins S, Young AH, Chaudhuri KR, Steier J, Skinner T, Bucks R, Rosenzweig I. Periodic limb movements during sleep: a narrative review. J Thorac Dis. 2021;13:6476–94.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Sun X, Wang J, Tang L, Xie A. Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis. Neurol Sci. 2017;38:163–70.

Article  PubMed  Google Scholar 

Melka D, Tafesse A, Bower JH, Assefa D. Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia. BMC Neurol. 2019;19:1–6.

Article  Google Scholar 

Kumar S, Bhatia M, Behari M. Sleep disorders in Parkinson's disease. Mov Disord. 2002;17:775–81.

Article  PubMed  Google Scholar 

Ylikoski A, Martikainen K, Partinen M. Parkinson's disease and restless legs syndrome. Eur Neurol. 2015;73:212–9.

Article  PubMed  Google Scholar 

Baumann-Vogel H, Hor H, Poryazova R, Valko P, Werth E, Baumann CR. REM sleep behavior in Parkinson disease: frequent, particularly with higher age. PLoS One. 2020;15:e0243454.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferman TJ, Boeve BF. Sleep in Parkinson’s disease and dementia with Lewy bodies. Psychiatry of Parkinson's Disease: Karger Publishers; 2012. p. 61–70.

Google Scholar 

Pistacchi M, Gioulis M, Contin F, Sanson F, Marsala SZ. Sleep disturbance and cognitive disorder: epidemiological analysis in a cohort of 263 patients. Neurol Sci. 2014;35:1955–62.

Article  PubMed  Google Scholar 

Elder GJ, Lazar AS, Alfonso-Miller P, Taylor JP. Sleep disturbances in Lewy body dementia: a systematic review. Int J Geriatr Psychiatry. 2022;37.

Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, Lugaresi E, Cortelli P. REM sleep behavior disorders in multiple system atrophy. Neurology. 1997;48:1094–6.

Article  CAS  PubMed  Google Scholar 

Lin J-Y, Zhang L-Y, Cao B, Wei Q-Q, Ou R-W, Hou Y-B, Liu K-C, Xu X-R, Jiang Z, Gu X-J. Sleep-related symptoms in multiple system atrophy: determinants and impact on disease severity. Chin Med J. 2021;134:690–8.

Article  Google Scholar 

Palma J-A, Fernandez-Cordon C, Coon EA, Low PA, Miglis MG, Jaradeh S, Bhaumik AK, Dayalu P, Urrestarazu E, Iriarte J. Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Clin Auton Res. 2015;25:69–75.

Article  PubMed  PubMed Central  Google Scholar 

Ghorayeb I, Yekhlef F, Chrysostome V, Balestre E, Bioulac B, Tison F. Sleep disorders and their determinants in multiple system atrophy. J Neurol Neurosurg Psychiatry. 2002;72:798–800.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vetrugno R, Provini F, Cortelli P, Plazzi G, Lotti EM, Pierangeli G, Canali C, Montagna P. Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. Sleep Med. 2004;5:21–30.

Article  PubMed  Google Scholar 

Moreno-López C, Santamaría J, Salamero M, Del Sorbo F, Albanese A, Pellecchia MT, Barone P, Overeem S, Bloem B, Aarden W. Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study). Arch Neurol. 2011;68:223–30.

Article  PubMed  Google Scholar 

Ghorayeb I, Dupouy S, Tison F, Meissner WG. Restless legs syndrome in multiple system atrophy. J Neural Transm. 2014;121:1523–7.

Article  PubMed  Google Scholar 

Stefanova N, Bücke P, Duerr S, Wenning GK. Multiple system atrophy: an update. Lancet Neurol. 2009;8:1172–8.

Article  CAS  PubMed  Google Scholar 

Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, Bottacchi E, Cannas A, Ceravolo G, Ceravolo R. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease. Movement disorders: official journal of the Movement Disorder Society. 2009;24:1641–9.

Article  PubMed  Google Scholar 

Maggi G, Trojano L, Barone P, Santangelo G. Sleep disorders and cognitive dysfunctions in Parkinson’s disease: a meta-analytic study. Neuropsychol Rev. 2021:1–40.

Biabani N, Birdseye A, Higgins S, Delogu A, Rosenzweig J, Cvetkovic Z, Nesbitt A, Drakatos P, Steier J, Kumari V, O'Regan D, Rosenzweig I. The neurophysiologic landscape of the sleep onset: a systematic review. J Thorac Dis. 2023;15:4530–43.

Article  PubMed  PubMed Central  Google Scholar 

Tall P, Qamar MA, Rosenzweig I, Raeder V, Sauerbier A, Heidemarie Z, Falup-Pecurariu C, Chaudhuri KR. The park sleep subtype in Parkinson's disease: from concept to clinic. Expert Opin Pharmacother. 2023;24:1725–36. An updated outline of treatment strategies for improvement of disorders of sleep and wakefulness in PD patients.

Article  PubMed  Google Scholar 

Alrouji M, Al-Kuraishy HM, Al-Gareeb AI, Zaafar D, Batiha GE-S. Orexin pathway in Parkinson’s disease: a review. Mol Biol Rep. 2023;1–14. A comprehensive review of implicated orexinergic pathways in Parkinson's disease.

Ogawa T, Kajiyama Y, Ishido H, Chiba S, Revankar GS, Nakano T, Taniguchi S, Kanbayashi T, Ikenaka K, Mochizuki H. Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson’s disease: a retrospective study. PLoS One. 2022;17:e0279747. A retrospective study that demonstrated decreased CSF orexin levels in patients with PD, but without correlation to clinical characteristics.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang S, Zhao Z, Ma J, Hu S, Li L, Wang Z, Sun W, Shi X, Li M, Zheng J. Increased plasma orexin-a concentrations are associated with the non-motor symptoms in Parkinson’s disease patients. Neurosci Lett. 2021;741:135480.

Article  CAS  PubMed  Google Scholar 

Inagawa Y, Shimizu S, Takenoshita N, Tsugawa A, Hirose D, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H, Kanetaka H. Association between cerebrospinal fluid orexin a level and severity of rapid eye movement sleep behaviour disorder in dementia with Lewy bodies. Psychogeriatrics: the official journal of the Japanese Psychogeriatric Society. 2021;21:128–30.

Article  PubMed  Google Scholar 

Al-Kuraishy HM, Abdulhadi MH, Hussien NR, Al-Niemi MS, Rasheed HA, Al-Gareeb AI. Involvement of orexinergic system in psychiatric and neurodegenerative disorders: a scoping review. Brain Circ. 2020;6:70.

Article  PubMed  PubMed Central  Google Scholar 

De Lecea L, Sutcliffe J. The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems. Cellular and Molecular Life Sciences CMLS. 1999;56:473–80.

Article  PubMed  PubMed Central  Google Scholar 

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573–85.

Article  CAS  PubMed  Google Scholar 

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