National Cancer Institute. Cancer stat facts: NHL: follicular lymphoma. https://seer.cancer.gov/statfacts/html/follicular.html. Accessed 2 Mar 2023.
Hanel W, Epperla N. Evolving therapeutic landscape in follicular lymphoma: a look at emerging and investigational therapies. J Hematol Oncol. 2021;14:104. https://doi.org/10.1186/s13045-021-01113-2.
Article CAS PubMed PubMed Central Google Scholar
Jacobson CA, Chavez JC, Sehgal AR, et al. Axicabtagene ciloleucel in relapsed or refractory indolent non-Hodgkin lymphoma (ZUMA-5): a single-arm, multicentre, phase 2 trial. Lancet Oncol. 2022;23:91–103. https://doi.org/10.1016/S1470-2045(21)00591-X.
Article CAS PubMed Google Scholar
Casulo C, Barr PM. How I treat early-relapsing follicular lymphoma. Blood. 2019;133:1540–7. https://doi.org/10.1182/blood-2018-08-822148.
Article CAS PubMed Google Scholar
Alcoceba M, Alonso-Álvarez S, García-Álvarez M, et al. Unmet needs in histological transformation of follicular lymphoma: a clinical and biological review. Ann Lymphoma. 2017;1:11. https://doi.org/10.21037/aol.2017.11.03.
Prusila REI, Sorigue M, Jauhiainen J, et al. Risk of secondary haematological malignancies in patients with follicular lymphoma: an analysis of 1028 patients treated in the rituximab era. Br J Haematol. 2019;187:364–71. https://doi.org/10.1111/bjh.16090.
Article CAS PubMed Google Scholar
Bello C, Zhang L, Naghashpour M. Follicular lymphoma: current management and future directions. Cancer Control. 2012;19:187–95. https://doi.org/10.1177/107327481201900303.
Casulo C, Byrtek M, Dawson KL, et al. Early relapse of follicular lymphoma after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone defines patients at high risk for death: an analysis from the National LymphoCare study. J Clin Oncol. 2015;33:2516–22. https://doi.org/10.1200/JCO.2014.59.7534.
Article CAS PubMed PubMed Central Google Scholar
Link BK, Day BM, Zhou X, et al. Second-line and subsequent therapy and outcomes for follicular lymphoma in the United States: data from the observational National LymphoCare study. Br J Haematol. 2019;184:660–3. https://doi.org/10.1111/bjh.15149.
NCCN. Clinical practice guidelines in oncology (NCCN Guidelines®) for B-cell lymphomas. V2.2023. https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf. Accessed 2 Mar 2023.
Ghielmini M, Vitolo U, Kimby E, et al. ESMO Guidelines Consensus Conference on Malignant Lymphoma 2011 part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). Ann Oncol. 2013;24:561–76. https://doi.org/10.1093/annonc/mds517.
Mozas P, Nadeu F, Rivas-Delgado A, et al. Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience. Blood Cancer J. 2020;10:31. https://doi.org/10.1038/s41408-020-0299-0.
Article PubMed PubMed Central Google Scholar
Morrison VA, Shou Y, Bell JA, et al. Treatment patterns and survival outcomes in patients with follicular lymphoma: a 2007 to 2015 Humedica Database study. Clin Lymphoma Myeloma Leuk. 2019;19:e172–83. https://doi.org/10.1016/j.clml.2018.12.017.
Rivas-Delgado A, Magnano L, Moreno-Velazquez M, et al. Response duration and survival shorten after each relapse in patients with follicular lymphoma treated in the rituximab era. Br J Haematol. 2019;184:753–9. https://doi.org/10.1111/bjh.15708.
Article CAS PubMed Google Scholar
Leonard JP, Trneny M, Izutsu K, et al. AUGMENT: a phase III study of lenalidomide plus rituximab versus placebo plus rituximab in relapsed or refractory indolent lymphoma. J Clin Oncol. 2019;37:1188–99. https://doi.org/10.1200/jco.19.00010.
Article CAS PubMed PubMed Central Google Scholar
Revlimid® (lenalidomide) [package insert]. Summit (NJ): Celgene Corporation; 2019.
Radford J, Davies A, Cartron G, et al. Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: results of the GAUDI study (BO21000). Blood. 2013;122:1137–43. https://doi.org/10.1182/blood-2013-01-481341.
Article CAS PubMed Google Scholar
Gazyva® (obinutuzumab) [package insert]. South San Francisco (CA): Genentech, Inc.; 2022.
Cheson BD, Chua N, Mayer J, et al. Overall survival benefit in patients with rituximab-refractory indolent non-Hodgkin lymphoma who received obinutuzumab plus bendamustine induction and obinutuzumab maintenance in the GADOLIN study. J Clin Oncol. 2018;36:2259–66. https://doi.org/10.1200/jco.2017.76.3656.
Article CAS PubMed Google Scholar
Sehn LH, Hübel K, Luminari S, et al. inMIND: a phase 3 study of tafasitamab plus lenalidomide and rituximab versus placebo plus lenalidomide and rituximab for relapsed/refractory follicular or marginal zone lymphoma. J Clin Oncol. 2022;40:Abstract TPS7583. https://doi.org/10.1200/JCO.2022.40.16_suppl.TPS7583.
Clinicaltrials.gov. A phase 3 study to assess efficacy and safety of tafasitamab plus lenalidomide and rituximab compared to placebo plus lenalidomide and rituximab in patients with relapsed/refractory (R/R) follicular lymphoma or marginal zone lymphoma (InMIND). Updated 2 Dec 2022. https://clinicaltrials.gov/ct2/show/NCT04680052. Accessed 2 Mar 2023.
Monjuvi® (tafasitamab-cxix) [package insert]. Boston (MA): MORPHOSYS US INC.; 2020.
Morschhauser F, Tilly H, Chaidos A, et al. Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial. Lancet Oncol. 2020;21:1433–42. https://doi.org/10.1016/S1470-2045(20)30441-1.
Article CAS PubMed PubMed Central Google Scholar
Tazverik™ (tazemetostat) [package insert]. Cambridge: Epizyme, Inc.; 2020.
Andorsky DJ, Coleman M, Yacoub A, et al. MAGNIFY phase IIIb interim analysis of induction R2 followed by maintenance in relapsed/refractory indolent NHL. J Clin Oncol. 2020;38:Abstract 8046. https://doi.org/10.1200/JCO.2020.38.15_suppl.8046.
Morschhauser F, Le Gouill S, Feugier P, et al. Obinutuzumab combined with lenalidomide for relapsed or refractory follicular B-cell lymphoma (GALEN): a multicentre, single-arm, phase 2 study. Lancet Haematol. 2019;6:e429–37. https://doi.org/10.1016/s2352-3026(19)30089-4.
Zelenetz AD, Jurczak W, Ribrag V, et al. Efficacy and safety of zandelisib administered by intermittent dosing (ID) in patients with relapsed or refractory (R/R) follicular lymphoma (FL): primary analysis of the global phase 2 study TIDAL. J Clin Oncol. 2022;40:Abstract 7511. https://doi.org/10.1200/JCO.2022.40.16_suppl.7511.
ClinicalTrials.gov. Phase 3 study of zandelisib (ME-401) in combination with rituximab in patients with iNHL - (COASTAL). Updated 13 Jan 2023. https://clinicaltrials.gov/ct2/show/NCT04745832. Accessed 2 Mar 2023.
ClinicalTrials.gov. Zandelisib (ME-401) in subjects with follicular lymphoma or marginal zone lymphoma after failure of two or more prior therapies (TIDAL). Updated 13 Jan 2023. https://clinicaltrials.gov/ct2/show/NCT03768505. Accessed 2 Mar 2023.
Gopal AK, Schuster SJ, Fowler NH, et al. Ibrutinib as treatment for patients with relapsed/refractory follicular lymphoma: results from the open-label, multicenter, phase II DAWN study. J Clin Oncol. 2018;36:2405–12. https://doi.org/10.1200/jco.2017.76.8853.
Article CAS PubMed Google Scholar
Zinzani PL, Mayer J, Flowers CR, et al. ROSEWOOD: a phase II randomized study of zanubrutinib plus obinutuzumab versus obinutuzumab monotherapy in patients with relapsed or refractory follicular lymphoma. J Clin Oncol. 2023;41(33):5107–17. https://doi.org/10.1200/JCO.23.00775.
Article CAS PubMed Google Scholar
Armand P, Janssens A, Gritti G, et al. Efficacy and safety results from CheckMate 140, a phase 2 study of nivolumab for relapsed/refractory follicular lymphoma. Blood. 2021;137:637–45. https://doi.org/10.1182/blood.2019004753.
Article CAS PubMed PubMed Central Google Scholar
Ding W, Laplant B, Witzig TE, et al. PD-1 blockade with pembrolizumab in relapsed low grade non-Hodgkin lymphoma. Blood. 2017;130:Abstract 4055. https://doi.org/10.1182/blood.V130.Suppl_1.4055.4055.
Sehn LH, Kamdar M, Herrera AF, et al. Randomized phase 2 trial of polatuzumab vedotin (pola) with bendamustine and rituximab (BR) in relapsed/refractory (r/r) FL and DLBCL. J Clin Oncol. 2018;36:Abstract 7507. https://doi.org/10.1200/JCO.2018.36.15_suppl.7507.
Brukinsa® (zanubrutinib) [package insert]. Cambridge (MA): BeiGene, Ltd; 2024.
Budde LE, Sehn LH, Matasar M, et al. Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study. Lancet Oncol. 2022;23:1055–65. https://doi.org/10.1016/s1470-2045(22)00335-7.
Article CAS PubMed Google Scholar
Lunsumio (mosunetuzumab) [package insert]. South San Francisco (CA): Genentech, Inc.; 2022.
Yescarta® (axicabtagene ciloleucel) [package insert]. Santa Monica (CA): Kite Pharma, Inc.; 2022.
Yescarta (axicabtagene ciloleucel) [summary of product characteristics]. Hoofddorp: Kite Pharma EU B.V.; 2022.
Fowler NH, Dickinson M, Dreyling M, et al. Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial. Nat Med. 2022;28:325–32. https://doi.org/10.1038/s41591-021-01622-0.
Article CAS PubMed Google Scholar
Kymriah® (tisagenlecleucel) [package insert]. East Hanover (NJ): Novartis Pharmaceuticals Corporation; 2022.
Goebeler ME, Knop S, Viardot A, et al. Bispecific T-cell engager (BiTE) antibody construct blinatumomab for the treatment of patients with relapsed/refractory non-Hodgkin lymphoma: final results from a phase I study. J Clin Oncol. 2016;34:1104–11. https://doi.org/10.1200/jco.2014.59.1586.
Article CAS PubMed Google Scholar
Hutchings M, Morschhauser F, Iacoboni G, et al. Glofitamab, a novel, bivalent CD20-targeting T-cell–engaging bispecific antibody, induces durable complete remissions in relapsed or refractory B-cell lymphoma: a phase I trial. J Clin Oncol. 2021;39:1959–70. https://doi.org/10.1200/jco.20.03175.
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