Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease

Tabor CW, Tabor H. Polyamines in microorganisms. Microbiol Rev. 1985;49:81–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurihara S, Suzuki H, Oshida M, Benno Y. A novel putrescine importer required for type 1 pili-driven surface motility induced by extracellular putrescine in Escherichia Coli K-12. J Biol Chem. 2011;286:10185–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michael AJ. Polyamines in eukaryotes, bacteria, and archaea. J Biol Chem. 2016;291:14896–903.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pegg AE. Mammalian polyamine metabolism and function. IUBMB Life. 2009;61:880–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lightfoot HL, Hall J. Endogenous polyamine function—the RNA perspective. Nucleic Acids Res. 2014;42:11275–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandal S, Mandal A, Johansson HE, Orjalo AV, Park MH. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc Natl Acad Sci. 2013;110:2169–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casero RA, Murray Stewart T, Pegg AE. Polyamine metabolism and cancer: treatments, challenges and opportunities. Nat Rev Cancer. 2018;18:681–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chia T-y, Zolp A, Miska J. Polyamine immunometabolism: central regulators of inflammation, cancer and autoimmunity. Cells. 2022;11:896.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holbert CE, Cullen MT, Casero RA, Stewart TM. Polyamines in cancer: integrating organismal metabolism and antitumour immunity. Nat Rev Cancer. 2022;22:467–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan AU, Di Mascio P, Medeiros MH, Wilson T. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen. Proc Natl Acad Sci U S A. 1992;89:11428–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan AU, Mei YH, Wilson T. A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen. Proc Natl Acad Sci U S A. 1992;89:11426–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA Jr. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998;95:11140–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ha HC, Yager JD, Woster PA, Casero RA Jr. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998;244:298–303.

Article  CAS  PubMed  Google Scholar 

Das KC, Misra HP. Hydroxyl radical scavenging and singlet oxygen quenching properties of polyamines. Mol Cell Biochem. 2004;262:127–33.

Article  CAS  PubMed  Google Scholar 

Fujisawa S, Kadoma Y. Kinetic evaluation of polyamines as radical scavengers. Anticancer Res. 2005;25:965–9.

CAS  PubMed  Google Scholar 

Pegg AE. Toxicity of polyamines and their metabolic products. Chem Res Toxicol. 2013;26:1782–800.

Article  CAS  PubMed  Google Scholar 

Bianchi M, Bellini A, Cervelli M, Degan P, Marcocci L, Martini F, Scatteia M, Mariottini P, Amendola R. Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure. Biochim Biophys Acta. 2007;1773:774–83.

Article  CAS  PubMed  Google Scholar 

Amendola R, Cervelli M, Fratini E, Polticelli F, Sallustio DE, Mariottini P. Spermine metabolism and anticancer therapy. Curr Cancer Drug Targets. 2009;9:118–30.

Article  CAS  PubMed  Google Scholar 

Amendola R, Cervelli M, Fratini E, Sallustio DE, Tempera G, Ueshima T, Mariottini P, Agostinelli E. Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments. Int J Oncol. 2013;43:813–20.

Article  CAS  PubMed  Google Scholar 

Perrone C, Pomella S, Cassandri M, Pezzella M, Giuliani S, Gasperi T, Porrazzo A, Alisi A, Pastore A, Codenotti S, Fanzani A, Barillari G, Conti LA, De Angelis B, Quintarelli C, Mariottini P, Locatelli F, Marampon F, Rota R, Cervelli M. Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation. Front Cell Dev Biol. 2023;11:1061570.

Article  PubMed  PubMed Central  Google Scholar 

Williams K. Interactions of polyamines with ion channels. Biochem J. 1997;325(Pt 2):289–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace HM, Fraser AV, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jänne J, Alhonen L, Pietilä M, Keinänen TA. Genetic approaches to the cellular functions of polyamines in mammals. Eur J Biochem. 2004;271:877–94.

Article  PubMed  Google Scholar 

Bowie D. Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins. J Biol Chem. 2018;293:18789–802.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stanfield PR, Sutcliffe MJ. Spermine is fit to block inward rectifier (Kir) channels. J Gen Physiol. 2003;122:481–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhara M, Matta JA, Lei M, Knowland D, Yu H, Gu S, Bredt DS. Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology. Nat Commun. 2020;11:2799.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makletsova MG, Rikhireva GT, Kirichenko EY, Trinitatsky IY, Vakulenko MY, Ermakov AM. The role of polyamines in the mechanisms of cognitive impairment. Neurochem J. 2022;16:283–94.

Article  CAS  Google Scholar 

Shin WW, Fong WF, Pang SF, Wong PC. Limited blood-brain barrier transport of polyamines. J Neurochem. 1985;44:1056–9.

Article  CAS  PubMed  Google Scholar 

Rieck J, Skatchkov SN, Derst C, Eaton MJ, Veh RW. Unique chemistry, intake, and metabolism of polyamines in the central nervous system (CNS) and its body. Biomolecules. 2022;12:501.

Article 

Comments (0)

No login
gif