Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716–724
Article CAS PubMed Google Scholar
Alexander JL, Mullish BH, Danckert NP et al (2023) The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients. EBioMedicine 88:104430
Article CAS PubMed PubMed Central Google Scholar
Allegretti JR, Mullish BH, Kelly C et al (2019) The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications. Lancet (london, England) 394(10196):420–431
Article CAS PubMed Google Scholar
Ansaldo E, Slayden LC, Ching KL et al (2019) Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science (new York, NY) 364(6446):1179–1184
Arumugam M, Raes J, Pelletier E et al (2011) Enterotypes of the human gut microbiome. Nature 473(7346):174–180
Article CAS PubMed PubMed Central Google Scholar
Atarashi K, Tanoue T, Shima T et al (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science (new York, NY) 331(6015):337–341
Atarashi K, Tanoue T, Ando M et al (2015) Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 163(2):367–380
Article CAS PubMed PubMed Central Google Scholar
Atarashi K, Suda W, Luo C et al (2017) Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation. Science (new York, NY) 358(6361):359–365
Belkaid Y, Harrison OJ (2017) Homeostatic immunity and the microbiota. Immunity 46(4):562–576
Article CAS PubMed PubMed Central Google Scholar
Burchill MA, Yang J, Vang KB et al (2008) Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112–121
Article CAS PubMed PubMed Central Google Scholar
Campbell C, McKenney PT, Konstantinovsky D et al (2020) Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature 581(7809):475–479
Article CAS PubMed PubMed Central Google Scholar
Campbell C, Kandalgaonkar MR, Golonka RM et al (2023) Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy. Biomedicines 11(2):294
Article CAS PubMed PubMed Central Google Scholar
Canale FP, Basso C, Antonini G et al (2021) Metabolic modulation of tumours with engineered bacteria for immunotherapy. Nature 598(7882):662–666
Article CAS PubMed Google Scholar
Chai JN, Peng Y, Rengarajan S et al (2017) Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation. Sci Immunol. https://doi.org/10.1126/sciimmunol.aal5068
Article PubMed PubMed Central Google Scholar
Correale J, Hohlfeld R, Baranzini SE (2022) The role of the gut microbiota in multiple sclerosis. Nat Rev Neurol 18(9):544–558
Article CAS PubMed Google Scholar
Davar D, Dzutsev AK, McCulloch JA et al (2021) Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science (new York, NY) 371(6529):595–602
de Lafaille MAC, Lafaille JJ (2009) Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30(5):626–635
Deng H, Li Z, Tan Y et al (2016) A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages. Sci Rep 6:29401
Article CAS PubMed PubMed Central Google Scholar
Duan J, Matute JD, Unger LW et al (2023) Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut. Immunity 56(5):1115–31.e9
Article CAS PubMed PubMed Central Google Scholar
Geuking MB, Burkhard R (2020) Microbial modulation of intestinal T helper cell responses and implications for disease and therapy. Mucosal Immunol 13(6):855–866
Article CAS PubMed Google Scholar
Gopalakrishnan V, Spencer CN, Nezi L et al (2018) Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science (new York, NY) 359(6371):97–103
Hang S, Paik D, Yao L et al (2019) Bile acid metabolites control T(H)17 and T(reg) cell differentiation. Nature 576(7785):143–148
Article CAS PubMed PubMed Central Google Scholar
Hegarty LM, Jones GR, Bain CC (2023) Macrophages in intestinal homeostasis and inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 20(8):538–553
Hezaveh K, Shinde RS, Klötgen A et al (2022) Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity. Immunity 55(2):324–40.e8
Article CAS PubMed PubMed Central Google Scholar
Hu C, Xu B, Wang X et al (2023) Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC. Hepatology (baltimore, MD) 77(1):48–64
Inamoto T, Furuta K, Han C et al (2023) Short-chain fatty acids stimulate dendrite elongation in dendritic cells by inhibiting histone deacetylase. FEBS J 290(24):5794–5910
Article CAS PubMed Google Scholar
Ivanov II, Atarashi K, Manel N et al (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139(3):485–498
Article CAS PubMed PubMed Central Google Scholar
Jobin C (2018) Precision medicine using microbiota. Science (new York, NY) 359(6371):32–34
Kayama H, Okumura R, Takeda K (2020) Interaction between the microbiota, epithelia, and immune cells in the intestine. Ann Rev Immunol 38:23–48
Kuczma MP, Szurek EA, Cebula A et al (2020) Commensal epitopes drive differentiation of colonic T(regs). Sci Adv 6(16):eaaz3186
Article CAS PubMed PubMed Central Google Scholar
Lavelle A, Sokol H (2020) Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 17(4):223–237
Leone RD, Powell JD (2020) Metabolism of immune cells in cancer. Nat Rev Cancer 20(9):516–531
Article CAS PubMed PubMed Central Google Scholar
Liu L, Huh JR, Shah K (2022) Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS. EBioMedicine 77:103908
Article CAS PubMed PubMed Central Google Scholar
Lu Y, Yuan X, Wang M et al (2022) Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies. J Hematol Oncol 15(1):47
Article PubMed PubMed Central Google Scholar
Macia L, Tan J, Vieira AT et al (2015) Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 6:6734
Article CAS PubMed Google Scholar
Mager LF, Burkhard R, Pett N et al (2020) Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Science (new York, NY) 369(6510):1481–1489
Merad M, Sathe P, Helft J et al (2013) The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 31(1):563–604
Article CAS PubMed Google Scholar
Michaudel C, Sokol H (2020) The Gut microbiota at the service of immunometabolism. Cell Metab 32(4):514–523
Comments (0)