Glucagon-like peptide-1 (GLP-1) receptor agonist

This class of drugs, like Liraglutide and Semaglutide, mimics the action of glucagon-like peptide-1 and help regulate appetite. These drugs are intended for use by adults and children (≥12 years) with obesity or by adults with overweight (body mass index (BMI) ≥ 27) in the presence of weight-related comorbidities (Source: www.saxenda.com; www.wegovy.com).

Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

This medication (Tirzepatide), when combined with calorie-deficit diet and exercise, is helpful for managing weight in adult with obesity or overweight individuals who have weight-related comorbidities (Source: www.zepbound.lilly.com).

Phentermine/Topiramate

Phentermine and Topiramate work together to control hunger and reduce cravings. This medication should be used in combination with a reduced-calorie diet and increased physical activity by patients aged 12 years and older with obesity or by adults with overweight (BMI ≥ 27) having weight-related comorbidities (Source: www.qsymia.com).

Hydrogel (Plenity)

This hydrogel capsule works by expanding in the stomach, creating a feeling of fullness and usually taken before meals with water. Hydrogel is recommended to help with weight management in adults with overweight or obesity (BMI 25–40) in combination with diet and exercise (Source: www.myplenity.com).

Naltrexone/Bupropion

Naltrexone and Bupropion work together to reduce hunger and control cravings and recommended in combination with lifestyle modifications in adults with obesity or overweight (BMI ≥ 27) and have weight-related medical conditions (Source: www.contrave.com).

Setmelanotide

This medication is to be used only in adults and children 6 years of age and older who have obesity due to deficiency of POMC, PCSK1, or the leptin receptor (Source: www.imcivree.com).

Orlistat

Orlistat inhibits fat absorption in the intestine and is indicated to aid weight loss with a reduced-calorie, low-fat diet. This drug is for adults only with obesity or overweight (BMI ≥ 27) who have risk factors like hypertension, diabetes, dyslipidemia. The over-the-counter version of orlistat (60 mg), can be taken by overweight adults with a BMI ≥ 25 (Source: www.xenical.com, www.myalli.com).