Global Cancer Observatory: Cancer Today. IARC: lung fact sheet; 2020. https://gco.iarc.fr/today/data/factsheets/cancers/15-Lung-fact-sheet.pdf. Accessed 20 June 2023.
Cancer.net. https://www.cancer.net/cancer-types/lung-cancer-non-small-cell. Accessed 20 Mar 2023.
National Cancer Institute/Surveillance, Epidemiology, and End Results Program. SEER 22. Adenocarcinoma of the Lung and Bronchus. Stage distribution of SEER incidence cases, 2011–2020. By sexes, all races/ethnicities, all ages. https://seer.cancer.gov/statfacts/html/lungb.html. Accessed 22 June 2023.
Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 2019;94(8):1623–40. https://doi.org/10.1016/j.mayocp.2019.01.013.
Article CAS PubMed Google Scholar
Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2004;22(14):2865–72. https://doi.org/10.1200/JCO.2004.12.149.
Waqar SN, Samson PP, Robinson CG, et al. Non-small-cell lung cancer with brain metastasis at presentation. Clin Lung Cancer. 2018;19(4):e373–9. https://doi.org/10.1016/j.cllc.2018.01.007.
Article PubMed PubMed Central Google Scholar
Lim JH, Um S-W. The risk factors for brain metastases in patients with non-small cell lung cancer. Ann Transl Med. 2018;6(Suppl 1):S66. https://doi.org/10.21037/atm.2018.10.27.
Arbour KC, Riely GJ. Systemic therapy for locally advanced and metastatic non-small cell lung cancer: a review. JAMA. 2019;322(8):764–74. https://doi.org/10.1001/jama.2019.11058.
Article CAS PubMed Google Scholar
Wu J, Liu Z, Huang T, Wang Y, et al. Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC. Mol Oncol. 2023;17(5):810–24.
Article CAS PubMed Google Scholar
Ali S, Górska Z, Duchnowska R, Jassem J. Molecular profiles of brain metastases: a focus on heterogeneity. Cancers (Basel). 2021;13(11):2645.
Article CAS PubMed Google Scholar
Kim M, Kizilbash SH, Laramy JK, et al. Barriers to effective drug treatment for brain metastases: a multifactorial problem in the delivery of precision medicine. Pharm Res. 2018;35(9):177. https://doi.org/10.1007/s11095-018-2455-9.
Article CAS PubMed PubMed Central Google Scholar
Rudmann DG. On-target and off-target-based toxicologic effects. Toxicol Pathol. 2013;41:310–4. https://doi.org/10.1177/0192623312464311.
Article CAS PubMed Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol. 2021;372:n71. https://doi.org/10.1136/bmj.n71.
Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane handbook for systematic reviews of interventions version 6.1 (updated September 2020). Cochrane, 2020. http://www.training.cochrane.org/handbook. Accessed 14 Aug 2023.
Sterne JAC, Savovic J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https://doi.org/10.1136/bmj.l4898.
Wells G, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 12 Jan 2021.
Addeo A, Hochmair M, Janzic U, et al. Treatment patterns, testing practices, and outcomes in the pre-FLAURA era for patients with EGFR mutation-positive advanced NSCLC: a retrospective chart review (REFLECT). Ther Adv Med Oncol. 2021;13:17588359211059874. https://doi.org/10.1177/17588359211059874.
Article PubMed PubMed Central Google Scholar
Bai H, Xiong L, Han B. The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer. Onco Targets Ther. 2017;10:2335–40. https://doi.org/10.2147/OTT.S129809.
Article CAS PubMed PubMed Central Google Scholar
Baldacci S, Besse B, Avrillon V, et al. Lorlatinib for advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: results of the IFCT-1803 LORLATU cohort. Eur J Cancer. 2022;166:51–9. https://doi.org/10.1016/j.ejca.2022.01.018.
Article CAS PubMed Google Scholar
Bilgin B, Sendur MAN, Yucel S, et al. Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in non-small cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study. J Cancer Res Clin Oncol. 2021;147(7):2145–52. https://doi.org/10.1007/s00432-020-03501-6.
Article CAS PubMed Google Scholar
Bozorgmehr F, Kazdal D, Chung I, et al. De novo versus secondary metastatic EGFR-mutated non-small-cell lung cancer. Front Oncol. 2021;11: 640048. https://doi.org/10.3389/fonc.2021.640048.
Article CAS PubMed PubMed Central Google Scholar
Camidge D, Kim HR, Ahn MJ, et al. Brigatinib versus crizotinib in ALK-positive non-small-cell lung cancer. New Engl J Med. 2018;379(21):2027–39. https://doi.org/10.1056/NEJMoa1810171.
Article CAS PubMed Google Scholar
Chang CY, Chen CY, Chang SC, et al. Efficacy and prognosis of first-line EGFR-tyrosine kinase inhibitor treatment in older adults including poor performance status patients with EGFR-mutated non-small-cell lung cancer. Cancer Manag Res. 2021;13:7187–201. https://doi.org/10.2147/CMAR.S322967.
Article PubMed PubMed Central Google Scholar
Chen C, Wu Y, Liu BL, et al. Whole-brain radiotherapy can improve the survival of patients with multiple brain metastases from non-small cell lung cancer treated by epidermal growth factor receptor-tyrosine kinase inhibitors. Cancer Manag Res. 2020;12:11333–40. https://doi.org/10.2147/CMAR.S279096.
Article PubMed PubMed Central Google Scholar
Chen YH, Chen YF, Chen CY, et al. Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study. BMC Cancer. 2019;19(1):1006. https://doi.org/10.1186/s12885-019-6140-0.
Article CAS PubMed PubMed Central Google Scholar
Chen CH, Lee HH, Chuang HY, et al. Combination of whole-brain radiotherapy with epidermal growth factor receptor tyrosine kinase inhibitors improves overall survival in EGFR-mutated non-small cell lung cancer patients with brain metastases. Cancers (Basel). 2019;11(8):1092. https://doi.org/10.3390/cancers11081092.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Wu A, Tao H, et al. Concurrent versus sequential whole brain radiotherapy and TKI in EGFR-mutated NSCLC patients with brain metastasis: a single institution retrospective analysis. Medicine (Baltimore). 2018;97(44):e13014. https://doi.org/10.1097/MD.0000000000013014.
Chiu TH, Tung PH, Huang CH, et al. The different overall survival between single-agent EGFR-TKI treatment and with bevacizumab in non-small cell lung cancer patients with brain metastasis. Sci Rep. 2022;12(1):4398. https://doi.org/10.1038/s41598-022-08449-w.
Article CAS PubMed PubMed Central Google Scholar
de Marinis F, Laktionov KK, Poltoratskiy A, et al. Afatinib in EGFR TKI-naïve patients with locally advanced or metastatic EGFR mutation-positive non-small cell lung cancer: interim analysis of a phase 3b study. Lung Cancer. 2021;152:127–34. https://doi.org/10.1016/j.lungcan.2020.12.011.
Article CAS PubMed Google Scholar
Doherty MK, Korpanty GJ, Tomasini P, et al. Treatment options for patients with brain metastases from EGFR/ALK-driven lung cancer. Radiother Oncol. 2017;123(2):195–202. https://doi.org/10.1016/j.radonc.2017.03.007.
Duruisseaux M, Besse B, Cadranel J, et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive non-small-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study. Oncotarget. 2017;8(13):21903–21917. https://doi.org/10.18632/oncotarget.15746.
El Shafie RA, Seidensaal K, Bozorgmehr F, et al. Effect of timing, technique and molecular features on brain control with local therapies in oncogene-driven lung cancer. ESMO Open. 2021;6(3):100161. https://doi.org/10.1016/j.esmoop.2021.100161.
Article PubMed PubMed Central Google Scholar
Gijtenbeek RGP, Damhuis RAM, Groen HJM, van der Wekken AJ, van Geffen WH. Nationwide real-world cohort study of first-line tyrosine kinase inhibitor treatment in epidermal growth factor receptor-mutated non-small-cell lung cancer. Clin Lung Cancer. 2020;21(6):e647–53. https://doi.org/10.1016/j.cllc.2020.05.019.
Article CAS PubMed Google Scholar
He ZY, Li MF, Lin JH, Lin D, Lin RJ. Comparing the efficacy of concurrent EGFR-TKI and whole-brain radiotherapy vs EGFR-TKI alone as a first-line therapy for advanced EGFR-mutated non-small-cell lung cancer with brain metastases: a retrospective cohort study. Cancer Manag Res. 2019;11:2129–38. https://doi.org/10.2147/CMAR.S184922.
Article CAS PubMed PubMed Central Google Scholar
Horn L, Wang Z, Wu G, et al. Ensartinib vs crizotinib for patients with anaplastic lymphoma kinase-positive non-small cell lung cancer: a randomized clinical trial. JAMA Oncol. 2021;7(11):1617–25. https://doi.org/10.1001/jamaoncol.2021.3523.
Huang AC, Huang CH, Ju JS, et al. First- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors in a large, real-world cohort of patients with non-small cell lung cancer. Ther Adv Med Oncol. 2021;13:17588359211035710. https://doi.org/10.1177/17588359211035710.
Article CAS PubMed PubMed Central Google Scholar
Huang CH, Ju JS, Chiu TH, et al. Afatinib treatment in a large real-world cohort of non-small cell lung cancer patients with common and uncommon epidermal growth factor receptor mutation. Int J Cancer. 2022;150(4):626–35. https://doi.org/10.1002/ijc.33821.
Comments (0)