Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study

Hollenberg SM, Singer M. Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol. 2021;18:424–34.

Article  PubMed  Google Scholar 

L’Heureux M, Sternberg M, Brath L, Turlington J, Kashiouris MG. Sepsis-induced cardiomyopathy: a comprehensive review. Curr Cardiol Rep. 2020;22:35.

Article  PubMed  PubMed Central  Google Scholar 

Schwartz PJ, Crotti L, Insolia R. Long-QT syndrome: from genetics to management. Circ Arrhythm Electrophysiol. 2012;5:868–77.

Article  PubMed  PubMed Central  Google Scholar 

El-Sherif N, Turitto G, Boutjdir M. Acquired long QT syndrome and torsade de pointes. Pacing Clin Electrophysiol. 2018;41:414–21.

Article  PubMed  Google Scholar 

Rodríguez-Jiménez AE, Cruz-Inerarity H, Negrín-Valdés T, Fardales-Rodríguez R, Chávez-González E. Corrected QT-interval dispersion: an electrocardiographic tool to predict recurrence of myocardial infarction. MEDICC Rev. 2019;21:22–5.

PubMed  Google Scholar 

Ahmed R, Kiya F, Kitano K, Takagi H, Hashiba K. Effects of combined changes in serum calcium and potassium on QT interval. A study by Holter electrocardiographic monitoring during hemodialysis. Jpn Heart J. 1987;28:813–28.

Article  CAS  PubMed  Google Scholar 

Varriale P, Ramaprasad S. Septic cardiomyopathy as a cause of long QT syndrome. J Electrocardiol. 1995;28:327–9.

Article  CAS  PubMed  Google Scholar 

Krogager ML, Kragholm K, Skals RK, Mortensen RN, Polcwiartek C, Graff C, et al. The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care. J Electrocardiol. 2019;57:104–11.

Article  PubMed  Google Scholar 

Marriott H. Miscellaneous conditions-hypokalemia. In: Marriott H, editor. Practical electrocardiography. Williams & Wilkins; 1988. p. 522–4.

Google Scholar 

Luo S, Michler K, Johnston P, Macfarlane PW. A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs. J Electrocardiol. 2004;37(Suppl):81–90.

Article  PubMed  Google Scholar 

Topilski I, Rogowski O, Rosso R, Justo D, Copperman Y, Glikson M, Belhassen B, Hochenberg M, Viskin S. The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias. J Am Coll Cardiol. 2007;49:320–8.

Article  PubMed  Google Scholar 

Tardo DT, Peck M, Subbiah RN, Vandenberg JI, Hill AP. The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: a systematic review. Ann Noninvasive Electrocardiol. 2023;28:e13015.

Article  PubMed  Google Scholar 

Moss AJ, Zareba W, Benhorin J, Locati EH, Hall WJ, Robinson JL, Schwartz PJ, Towbin JA, Vincent GM, Lehmann MH. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation. 1995;92:2929–34.

Article  CAS  PubMed  Google Scholar 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315:801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–726.

Article  CAS  PubMed  Google Scholar 

Group KDIGOKAKIW. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. 2012;2012:1–138.

Google Scholar 

Fernández Ceballos I, Steinberg E, Ems J, Nuñez Silveira JM, Madorno M, Carboni Bisso I, Las Heras M, Cornejo R. Physiological effect of high flow oxygen therapy measured by electrical impedance tomography in single-lung transplantation. Medicina (B Aires). 2024;84:148–52.

PubMed  Google Scholar 

Shingina A, Mukhtar N, Wakim-Fleming J, Alqahtani S, Wong RJ, Limketkai BN, Larson AM, Grant L. Acute liver failure guidelines. Am J Gastroenterol. 2023;118:1128–53.

Article  PubMed  Google Scholar 

Bajaj JS, O’Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS. Acute-on-chronic liver failure clinical guidelines. Am J Gastroenterol. 2022;117:225–52.

Article  PubMed  Google Scholar 

Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al. 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American college of cardiology/American heart association joint committee on clinical practice guidelines. Circulation. 2024;149:e1–156.

Article  PubMed  Google Scholar 

Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43:3997–4126.

Article  PubMed  Google Scholar 

Kannankeril P, Roden DM, Darbar D. Drug-induced long QT syndrome. Pharmacol Rev. 2010;62:760–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Said TH, Lance DW, Jeyaraj D, Fossa AA, Rosenbaum DS. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia. J Cardiovasc Pharmacol. 2012;60:165–71.

Article  CAS  PubMed  Google Scholar 

Mahida S, Hogarth AJ, Cowan C, Tayebjee MH, Graham LN, Pepper CB. Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives. J Interv Card Electrophysiol. 2013;37:9–19.

Article  PubMed  Google Scholar 

Kim ED, Watt J, Tereshchenko LG, Jaar BG, Sozio SM, Kao WHL, Estrella MM, Parekh RS. Associations of serum and dialysate electrolytes with QT interval and prolongation in incident hemodialysis: the predictors of arrhythmic and cardiovascular risk in end-stage renal disease (PACE) study. BMC Nephrol. 2019;20:133.

Article  PubMed  PubMed Central  Google Scholar 

Yu H, Zhang L, Liu J, Liu Y, Kowey PR, Zhang Y, et al. Acquired long QT syndrome in hospitalized patients. Heart Rhythm. 2017;14:974–8.

Article  PubMed  Google Scholar 

Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ. Development and validation of a risk score to predict QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes. 2013;6:479–87.

Article  PubMed  PubMed Central  Google Scholar 

Overton K, Post JJ. Association between altered QT interval in sepsis and mortality: a possible effect of antimicrobial therapy? Intern Med J. 2017;47:1216–7.

Article  PubMed  Google Scholar 

Wasserstrum Y, Lotan D, Itelman E, Barbarova I, Kogan M, Klempfner R, Dagan A, Segal G. Corrected QT interval anomalies are associated with worse prognosis among patients suffering from sepsis. Intern Med J. 2016;46:1204–11.

Article  CAS  PubMed  Google Scholar 

Barashi R, Milwidsky A, Viskin D, Giladi M, Hochstadt A, Morgan S, Rosso R, Chorin E, Viskin S. Teleological reasoning for QT prolongation caused by severe bradycardia: correlation between QT interval and brain natriuretic peptide levels during atrioventricular block. Heart Rhythm. 2024;21:106–12.

Article  PubMed  Google Scholar 

Galluzzo A, Gallo C, Battaglia A, Frea S, Canavosio FG, Botta M, Bergerone S, Gaita F. Prolonged QT interval in ST-elevation myocardial infarction: predictors and prognostic value in medium-term follow-up. J Cardiovasc Med (Hagerstown). 2016;17:440–5.

Article  CAS  PubMed  Google Scholar 

Buttà C, Zappia L, Laterra G, Roberto M. Diagnostic and prognostic role of electrocardiogram in acute myocarditis: a comprehensive review. Ann Noninvasive Electrocardiol. 2020;25:e12726.

Article  PubMed  Google Scholar 

Banai A, Szekely Y, Lupu L, Borohovitz A, Levi E, Ghantous E, Taieb P, Hochstadt A, Banai S, Topilsky Y, et al. QT interval prolongation is a novel predictor of 1-year mortality in patients With COVID-19 infection. Front Cardiovasc Med. 2022;9:869089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pool R, Gomez H, Kellum JA. Mechanisms of organ dysfunction in sepsis. Crit Care Clin. 2018;34:63–80.

Article  PubMed  Google Scholar 

Li D, Weng Y, Zhen G, Jiang L. Tp-Te interval and Tp-Te/qt ratio are valuable tools in predicting poor outcome in sepsis patients. Front Cardiovasc Med. 2022;9:879085.

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif