Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms

Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol. 2011;25:3–18. https://doi.org/10.1016/j.bpg.2010.12.010.

Article  PubMed  Google Scholar 

Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, et al. Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria. J Pediatr. 2018;195:134–9. https://doi.org/10.1016/j.jpeds.2017.12.012.

Article  PubMed  Google Scholar 

Tabbers MM, DiLorenzo C, Berger MY, Faure C, Langendam MW, Nurko S, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58:258–74. https://doi.org/10.1097/MPG.0000000000000266.

Article  CAS  PubMed  Google Scholar 

van Mill MJ, Koppen IJN, Benninga MA. Controversies in the management of functional constipation in children. Curr Gastroenterol Rep. 2019;21:23. https://doi.org/10.1007/s11894-019-0690-9.

Article  PubMed  Google Scholar 

Bongers MEJ, van Wijk MP, Reitsma JB, Benninga MA. Long-term prognosis for childhood constipation: clinical outcomes in adulthood. Pediatrics. 2010;126:e156–62. https://doi.org/10.1542/peds.2009-1009.

Article  PubMed  Google Scholar 

Baran M, Cagan Appak Y, Karakoyun M, Yalcinkaya S, Eliacik K, Dundar BN. The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment. Eur J Gastroenterol Hepatol. 2017;29:1264–8. https://doi.org/10.1097/MEG.0000000000000979.

Article  PubMed  Google Scholar 

Hirsch S, Nurko S, Mitchell P, Rosen R. Prucalopride for treatment of upper gastrointestinal symptoms in children. Paediatr Drugs. 2022;24:73–81. https://doi.org/10.1007/s40272-021-00489-5.

Article  PubMed  Google Scholar 

Winter HS, Di Lorenzo C, Benninga MA, Gilger MA, Kearns GL, Hyman PE, et al. Oral prucalopride in children with functional constipation. J Pediatr Gastroenterol Nutr. 2013;57:197–203. https://doi.org/10.1097/MPG.0b013e318292f9ea.

Article  CAS  PubMed  Google Scholar 

Singh R, Zogg H, Ghoshal UC, Ro S. Current treatment options and therapeutic insights for gastrointestinal dysmotility and functional gastrointestinal disorders. Front Pharmacol. 2022;13: 808195. https://doi.org/10.3389/fphar.2022.808195.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camilleri M, Atieh J. New Developments in prokinetic therapy for gastric motility disorders. Front Pharmacol. 2021;12: 711500. https://doi.org/10.3389/fphar.2021.711500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mutalib M, Kammermeier J, Vora R, Borrelli O. Prucalopride in intestinal pseudo obstruction, paediatric experience and systematic review. Acta Gastro Enterol Belg. 2021;84:429–34. https://doi.org/10.51821/84.3.002.

Article  CAS  Google Scholar 

Drug Approval Package: Motegrity (prucalopride) n.d. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210166Orig1s000TOC.cfm. Accessed 21 Feb 2022.

Camilleri M, Van Outryve MJ, Beyens G, Kerstens R, Robinson P, Vandeplassche L. Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation—follow-up of patients from the pivotal studies. Aliment Pharmacol Ther. 2010;32:1113–23. https://doi.org/10.1111/j.1365-2036.2010.04455.x.

Article  CAS  PubMed  Google Scholar 

US Food and Drug Administration. FDA Talk Paper 00-14: Janssen Pharmaceutic stops marketing cisapride in the US. 2000. www.fda.gov. Accessed on 21 Feb 2022.

Tameez Ud Din A, Khan AH, Bajwa H, Maqsood MH, Malik MN. Clinical efficacy and safety profile of prucalopride in chronic idiopathic constipation. Cureus. 2019;11:e4382. https://doi.org/10.7759/cureus.4382.

Article  PubMed  PubMed Central  Google Scholar 

Carbone F, Van den Houte K, Clevers E, Andrews CN, Papathanasopoulos A, Holvoet L, et al. Prucalopride in gastroparesis: a randomized placebo-controlled crossover study. Am J Gastroenterol. 2019;114:1265–74. https://doi.org/10.14309/ajg.0000000000000304.

Article  PubMed  Google Scholar 

Mugie SM, Korczowski B, Bodi P, Green A, Kerstens R, Ausma J, et al. Prucalopride is no more effective than placebo for children with functional constipation. Gastroenterology. 2014;147:1285-1295.e1. https://doi.org/10.1053/j.gastro.2014.09.005.

Article  CAS  PubMed  Google Scholar 

Ho D, Imai K, King G, Stuart EA. MatchIt: nonparametric preprocessing for parametric causal inference. J Stat Softw. 2011;42:1–28. https://doi.org/10.18637/jss.v042.i08.

Article  Google Scholar 

van Ginkel R, Reitsma JB, Büller HA, van Wijk MP, Taminiau JAJM, Benninga MA. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003;125:357–63. https://doi.org/10.1016/S0016-5085(03)00888-6.

Article  PubMed  Google Scholar 

Gershon MD. Review article: serotonin receptors and transporters—roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther. 2004;20:3–14. https://doi.org/10.1111/j.1365-2036.2004.02180.x.

Article  CAS  PubMed  Google Scholar 

Sikander A, Rana SV, Prasad KK. Role of serotonin in gastrointestinal motility and irritable bowel syndrome. Clin Chim Acta. 2009;403:47–55. https://doi.org/10.1016/j.cca.2009.01.028.

Article  CAS  PubMed  Google Scholar 

Tack J, Camilleri M, Chang L, Chey WD, Galligan JJ, Lacy BE, et al. Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012;35:745–67. https://doi.org/10.1111/j.1365-2036.2012.05011.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Schaick E, Benninga MA, Levine A, Magnusson M, Troy S. Development of a population pharmacokinetic model of prucalopride in children with functional constipation. Pharmacol Res Perspect. 2016;4: e00236. https://doi.org/10.1002/prp2.236.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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