CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway

Viens L, Perin D, Senkomago V, Neri A, Saraiya M. Questions about cervical and Breast Cancer screening knowledge, practice, and outcomes: a review of demographic and health surveys. J Womens Health (Larchmt). 2017;26(5):403–12.

Article  PubMed  Google Scholar 

Li S, Wang Y, Feng C, Wu G, Ye Y, Tian J. Calycosin inhibits the Migration and Invasion of human Breast Cancer cells by down-regulation of Foxp3 expression. Cell Physiol Biochem. 2017;44(5):1775–84.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Lin M, Wang J, Yang F, Yang P, Liu Y, Chen Z, Zheng Y. Calycosin inhibits Breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-beta1. Aging. 2021;13(12):16009–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng YJ, Nie XY, Ji CC, Lin XX, Liu LJ, Chen XM, Yao H, Wu SH. Long-Term Cardiovascular Risk after Radiotherapy in Women with Breast Cancer. J Am Heart Assoc. 2017;6(5).

Corona SP, Sobhani N, Ianza A, Roviello G, Mustacchi G, Bortul M, Zanconati F, Generali D. Advances in systemic therapy for metastatic Breast cancer: future perspectives. Med Oncol. 2017;34(7):119.

Article  CAS  PubMed  Google Scholar 

Chen T, You Y, Jiang H, Wang ZZ. Epithelial-mesenchymal transition (EMT): a biological process in the development, stem cell differentiation, and tumorigenesis. J Cell Physiol. 2017;232(12):3261–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan QZ, Li K, Yang ZD, Gao M, Shi JH, Ren SP, Zhao GQ. Dexmedetomidine attenuates high glucose-induced HK-2 epithelial-mesenchymal transition by inhibiting AKT and ERK. Biomed Environ Sci. 2020;33(5):323–30.

CAS  PubMed  Google Scholar 

Pastushenko I, Blanpain C. EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol. 2019;29(3):212–26.

Article  CAS  PubMed  Google Scholar 

Pereira SS, Monteiro MP, Costa MM, Ferreira J, Alves MG, Oliveira PF, Jarak I, Pignatelli D. MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors. J Cell Biochem. 2019;120(1):894–906.

Article  CAS  PubMed  Google Scholar 

Murai Y, Jo U, Murai J, Jenkins LM, Huang SN, Chakka S, Chen L, Cheng K, Fukuda S, Takebe N, et al. SLFN11 inactivation induces proteotoxic stress and sensitizes Cancer cells to Ubiquitin activating enzyme inhibitor TAK-243. Cancer Res. 2021;81(11):3067–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noi M, Mukaisho KI, Murakami S, Koshinuma S, Machida Y, Yamori M, Nakayama T, Ogawa T, Nakata Y, Shimizu T, et al. Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with Tumor characteristics and patient survival. Clin Exp Dent Res. 2020;6(4):420–7.

Article  PubMed  PubMed Central  Google Scholar 

El-Sayes N, Vito A, Mossman K. Tumor heterogeneity: a great barrier in the age of cancer immunotherapy. Cancers (Basel). 2021;13(4).

Asgari R, Vaisi-Raygani A, Aleagha MSE, Mohammadi P, Bakhtiari M, Arghiani N. CD147 and MMPs as key factors in physiological and pathological processes. Biomed Pharmacother. 2023;157:113983.

Article  CAS  PubMed  Google Scholar 

Wang N, Jiang X, Zhang S, Zhu A, Yuan Y, Xu H, Lei J, Yan C. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell. 2021;184(2):370–383e313.

Article  CAS  PubMed  Google Scholar 

Guo N, Miao R, Gao X, Huang D, Hu Z, Ji N, Nan Y, Jiang F, Gou X. Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147. Mol Med Rep. 2019;19(5):4335–43.

CAS  PubMed  PubMed Central  Google Scholar 

Shi WP, Ju D, Li H, Yuan L, Cui J, Luo D, Chen ZN, Bian H. CD147 promotes CXCL1 expression and modulates liver fibrogenesis. Int J Mol Sci 2018, 19(4).

Su J, Gao T, Jiang M, Wu L, Zeng W, Zhao S, Peng C, Chen X. CD147 silencing inhibits Tumor growth by suppressing glucose transport in Melanoma. Oncotarget. 2016;7(40):64778–84.

Article  PubMed  PubMed Central  Google Scholar 

Lian C, Guo Y, Zhang J, Chen X, Peng C. Targeting CD147 is a Novel Strategy for Antitumor Therapy. Curr Pharm Des. 2017;23(29):4410–21.

Article  CAS  PubMed  Google Scholar 

Amit-Cohen BC, Rahat MM, Rahat MA. Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN. Front Physiol. 2013;4:178.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatanaka M, Higashi Y, Kawai K, Su J, Zeng W, Chen X, Kanekura T. CD147-targeted siRNA in A375 malignant Melanoma cells induces the phosphorylation of EGFR and downregulates cdc25C and MEK phosphorylation. Oncol Lett. 2016;11(4):2424–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li F, Zhang J, Guo J, Jia Y, Han Y, Wang Z. RNA interference targeting CD147 inhibits Metastasis and invasion of human Breast cancer MCF-7 cells by downregulating MMP-9/VEGF expression. Acta Biochim Biophys Sin (Shanghai). 2018;50(7):676–84.

Article  CAS  PubMed  Google Scholar 

Yang JM, Xu Z, Wu H, Zhu H, Wu X, Hait WN. Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res. 2003;1(6):420–7.

CAS  PubMed  Google Scholar 

Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, et al. Single-cell transcriptomic analysis of primary and metastatic Tumor ecosystems in Head and Neck Cancer. Cell. 2017;171(7):1611–1624e1624.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang N, Liu Z, Lai X, Liu S, Wang Y. Silencing of CD147 inhibits cell proliferation, migration, invasion, lipid metabolism dysregulation and promotes apoptosis in lung adenocarcinoma via blocking the Rap1 signaling pathway. Respir Res. 2023;24(1):253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dana P, Saisomboon S, Kariya R, et al. CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF-κB pathway promotes cholangiocarcinoma migration and invasion. Cell Oncol (Dordr). 2020;43(2):211–22.

Article  CAS  PubMed  Google Scholar 

Wang SJ, Chao D, Wei W, et al. CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma. J Exp Clin Cancer Res. 2020;39(1):145.

Article  PubMed  PubMed Central  Google Scholar 

Bhushan A, Gonsalves A, Menon JU. Current state of Breast Cancer diagnosis, treatment, and Theranostics. Pharmaceutics 2021, 13(5).

Grass GD, Dai L, Qin Z, Parsons C, Toole BP. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance. Adv Cancer Res. 2014;123:351–73.

Article  PubMed  Google Scholar 

Amjad MT, Chidharla A, Kasi A. Cancer Chemotherapy. In: StatPearls, editor. Treasure Island (FL) ineligible companies. Disclosure: Anusha Chidharla declares no relevant financial relationships with ineligible companies. Disclosure: Anup Kasi declares no relevant financial relationships with ineligible companies.; 2023.

Google Scholar 

Liang GB, Wei JH, Jiang H, Huang RZ, Qin JT, Wang HL, Wang HS, Zhang Y. Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA. Eur J Med Chem. 2021;210:112951.

Article  CAS  PubMed  Google Scholar 

Xiong L, Ding L, Ning H, Wu C, Fu K, Wang Y, Zhang Y, Liu Y, Zhou L. CD147 knockdown improves the antitumor efficacy of trastuzumab in HER2-positive Breast cancer cells. Oncotarget. 2016;7(36):57737–51.

Article  PubMed  PubMed Central  Google Scholar 

Mittal V. Epithelial mesenchymal transition in Tumor Metastasis. Annu Rev Pathol. 2018;13:395–412.

Article  CAS  PubMed  Google Scholar 

Kaszak I, Witkowska-Pilaszewicz O, Niewiadomska Z, Dworecka-Kaszak B, Ngosa Toka F, Jurka P. Role of cadherins in Cancer-A Review. Int J Mol Sci 2020, 21(20).

Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scheau C, Badarau IA, Costache R, Caruntu C, Mihai GL, Didilescu AC, Constantin C, Neagu M. The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma. Anal Cell Pathol (Amst) 2019, 2019:9423907.

Tang X, Sui X, Weng L, Liu Y. SNAIL1: linking Tumor Metastasis to Immune Evasion. Front Immunol. 2021;12:724200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patrizz A, Doran SJ, Chauhan A, Ahnstedt H, Roy-O’Reilly M, Lai YJ, Weston G, Tarabishy S, Patel AR, Verma R, et al. EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic Stroke. Aging. 2020;12(6):5121–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahat MA, Safieh M, Simanovich E, Pasand E, Gazitt T, Haddad A, Elias M, Zisman D. The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis. Arthritis Res Ther. 2020;22(1):240.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu T, Zhou M, Peng L, Kong S, Miao R, Shi Y, Sheng H, Li L. Upregulation of CD147 promotes cell invasion, epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in Colorectal cancer. Int J Clin Exp Pathol. 2014;7(11):7432–41.

PubMed  PubMed Central  Google Scholar 

Kim JY, Kim WJ, Kim H, Suk K, Lee WH. The stimulation of CD147 induces MMP-9 expression through ERK and NF-kappaB in macrophages: implication for Atherosclerosis. Immune Netw. 2009;9(3):90–7.

Article 

Comments (0)

No login
gif