Pishesha N, Harmand TJ, Ploegh HL. A guide to antigen processing and presentation. Nat Rev Immunol. 2022;22:751–64.
Article PubMed CAS Google Scholar
Wong-Benito V, de Rijke J, Dixon B. Antigen presentation in vertebrates: structural and functional aspects. Dev Comp Immunol. 2023;144:104702.
Article PubMed CAS Google Scholar
Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A, Tampe R. Structure of the human MHC-I peptide-loading complex. Nature. 2017;551:525–8.
Article PubMed CAS Google Scholar
Rock KL, Reits E, Neefjes J. Present yourself! By MHC class I and MHC class II molecules. Trends Immunol. 2016;37:724–37.
Article PubMed PubMed Central CAS Google Scholar
van Hateren A, Elliott T. The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing. Curr Opin Immunol. 2021;70:138–43.
Sykulev Y. Factors contributing to the potency of CD8(+) T cells. Trends Immunol 2023.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, et al. Autophagy promotes immune evasion of Pancreatic cancer by degrading MHC-I. Nature. 2020;581:100–5.
Article PubMed PubMed Central CAS Google Scholar
Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer Immune Evasion through loss of MHC Class I Antigen Presentation. Front Immunol. 2021;12:636568.
Article PubMed PubMed Central CAS Google Scholar
Flajnik MF, Kasahara M. Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat Rev Genet. 2010;11:47–59.
Article PubMed CAS Google Scholar
Creech AL, Ting YS, Goulding SP, Sauld JFK, Barthelme D, Rooney MS, Addona TA, Abelin JG. The role of Mass Spectrometry and Proteogenomics in the Advancement of HLA Epitope Prediction. Proteomics. 2018;18:e1700259.
Murali-Krishna K, Lau LL, Sambhara S, Lemonnier F, Altman J, Ahmed R. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science. 1999;286:1377–81.
Article PubMed CAS Google Scholar
Benko S, Kovacs EG, Hezel F, Kufer TA. NLRC5 functions beyond MHC I regulation-what do we know so far? Front Immunol. 2017;8:150.
Article PubMed PubMed Central Google Scholar
Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hosel M, Buning H, Schwarzenbacher R, Kufer TA. A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem. 2010;285:26223–32.
Article PubMed PubMed Central CAS Google Scholar
Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, et al. Opposing functions of Interferon Coordinate Adaptive and Innate Immune responses to Cancer Immune Checkpoint Blockade. Cell. 2019;178:933–948e914.
Article PubMed PubMed Central CAS Google Scholar
Chen X, Lu Q, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J et al. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. Cell 2023.
Luo N, Nixon MJ, Gonzalez-Ericsson PI, Sanchez V, Opalenik SR, Li H, Zahnow CA, Nickels ML, Liu F, Tantawy MN, et al. DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in Breast cancer. Nat Commun. 2018;9:248.
Article PubMed PubMed Central Google Scholar
Ren J, Li N, Pei S, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y et al. Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-gamma-stimulated antitumor immunity. J Clin Invest 2022, 132.
Sun T, Li Y, Yang W, Wu H, Li X, Huang Y, Zhou Y, Du Z. Histone deacetylase inhibition up-regulates MHC class I to facilitate cytotoxic T lymphocyte-mediated Tumor cell killing in glioma cells. J Cancer. 2019;10:5638–45.
Article PubMed PubMed Central CAS Google Scholar
Hu Y, Pei W, Hu Y, Li P, Sun C, Du J, Zhang Y, Miao F, Zhang A, Shen Y, Zhang J. MiR34a regulates neuronal MHC class I molecules and promotes primary hippocampal neuron dendritic growth and branching. Front Cell Neurosci. 2020;14:573208.
Article PubMed PubMed Central CAS Google Scholar
Zheng J, Yang T, Gao S, Cheng M, Shao Y, Xi Y, Guo L, Zhang D, Gao W, Zhang G, et al. miR-148a-3p silences the CANX/MHC-I pathway and impairs CD8(+) T cell-mediated immune Attack in Colorectal cancer. FASEB J. 2021;35:e21776.
Article PubMed CAS Google Scholar
Mari L, Hoefnagel SJM, Zito D, van de Meent M, van Endert P, Calpe S, Sancho Serra MDC, Heemskerk MHM, van Laarhoven HWM, Hulshof M, et al. microRNA 125a regulates MHC-I expression on Esophageal Adenocarcinoma Cells, Associated with suppression of Antitumor Immune response and poor outcomes of patients. Gastroenterology. 2018;155:784–98.
Article PubMed CAS Google Scholar
Jhunjhunwala S, Hammer C, Delamarre L. Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nat Rev Cancer. 2021;21:298–312.
Article PubMed CAS Google Scholar
Dersh D, Holly J, Yewdell JW. A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion. Nat Rev Immunol. 2021;21:116–28.
Article PubMed CAS Google Scholar
Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, et al. The SPPL3-Defined glycosphingolipid repertoire orchestrates HLA class I-Mediated Immune responses. Immunity. 2021;54:132–150e139.
Article PubMed CAS Google Scholar
Ito Y, Pan D, Zhang W, Zhang X, Juan TY, Pyrdol JW, Kyrysyuk O, Doench JG, Liu XS, Wucherpfennig KW. Addressing Tumor heterogeneity by sensitizing resistant Cancer cells to T cell-secreted cytokines. Cancer Discov. 2023;13:1186–209.
Article PubMed PubMed Central CAS Google Scholar
Westrich JA, Vermeer DW, Silva A, Bonney S, Berger JN, Cicchini L, Greer RO, Song JI, Raben D, Slansky JE, et al. CXCL14 suppresses human papillomavirus-associated Head and Neck cancer through antigen-specific CD8(+) T-cell responses by upregulating MHC-I expression. Oncogene. 2019;38:7166–80.
Article PubMed PubMed Central CAS Google Scholar
Andre P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Blery M, Bonnafous C, Gauthier L, Morel A, et al. Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK Cells. Cell. 2018;175:1731–1743e1713.
Article PubMed PubMed Central CAS Google Scholar
Abd Hamid M, Wang RZ, Yao X, Fan P, Li X, Chang XM, Feng Y, Jones S, Maldonado-Perez D, Waugh C, et al. Enriched HLA-E and CD94/NKG2A Interaction limits Antitumor CD8(+) tumor-infiltrating T lymphocyte responses. Cancer Immunol Res. 2019;7:1293–306.
van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, Andre P, et al. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer vaccines. Cell. 2018;175:1744–1755e1715.
Article PubMed PubMed Central Google Scholar
Lerner EC, Woroniecka KI, D’Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD et al. CD8(+) T cells maintain killing of MHC-I-negative Tumor cells through the NKG2D-NKG2DL axis. Nat Cancer 2023.
Eugene J, Jouand N, Ducoin K, Dansette D, Oger R, Deleine C, Leveque E, Meurette G, Podevin J, Matysiak T, et al. The inhibitory receptor CD94/NKG2A on CD8(+) tumor-infiltrating lymphocytes in Colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/beta2m overexpression. Mod Pathol. 2020;33:468–82.
Article PubMed CAS Google Scholar
Liu X, Song J, Zhang H, Liu X, Zuo F, Zhao Y, Zhao Y, Yin X, Guo X, Wu X, et al. Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating Tumor cells from NK cell surveillance. Cancer Cell. 2023;41:272–287e279.
Article PubMed CAS Google Scholar
Krijgsman D, Roelands J, Hendrickx W, Bedognetti D, Kuppen PJK. HLA-G: a New Immune Checkpoint in Cancer? Int J Mol Sci 2020, 21.
Wolf NK, Kissiov DU, Raulet DH. Roles of natural killer cells in immunity to cancer, and applications to immunotherapy. Nat Rev Immunol. 2023;23:90–105.
Article PubMed CAS Google Scholar
Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr., Harvey CJ, et al. Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven Tumor immunity. Science. 2018;359:1537–42.
Article PubMed PubMed Central CAS Google Scholar
Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest. 2014;124:4781–94.
Article PubMed PubMed Central Google Scholar
Neo SY, Jing X, Tong L, Tong D, Gao J, Chen Z, De Los Santos MC, Burduli N, De Souza Ferreira S, Wagner AK et al. Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells. J Immunother Cancer 2022, 10.
Marchesi M, Andersson E, Villabona L, Seliger B, Lundqvist A, Kiessling R, Masucci GV. HLA-dependent tumour development: a role for tumour associate macrophages? J Transl Med. 2013;11:247.
Comments (0)