The patient was a woman in her 40 s in whom an abnormal thyroid function had been noted 2 years previously, before her referral to our hospital. She consulted a hospital complaining of fatigue and vomiting. At consultation, she also had consciousness disorder, tachycardia, thyromegaly, increased thyroid blood flow, and hyperthyroidism and was diagnosed with thyroid storm. She was referred to our hospital with administration of a β1-blocker and hydrocortisone.

On arrival in the emergency department, a physical examination revealed the following: blood pressure, 110/80 mmHg; pulse, 220 beats per minute with atrial fibrillation; respiration, 60 breaths per minute; body temperature, 39.6 °C; and Glasgow Coma Scale (GCS), 9. Her blood pressure gradually declined, and she experienced cardiopulmonary arrest. After return of spontaneous circulation, an ultrasound cardiogram showed that the ejection fraction was 47%, the transtricuspid pressure gradient was 32 mmHg, and the diameter of the inferior vena cava during expiration and inspiration was 27 and 22 mm, respectively. Hemodynamics were not sustained, so venoarterial extracorporeal membrane oxygenation (ECMO) was initiated. The laboratory findings were as follows: white cell count, 6400/μL; hemoglobin, 10.7 g/dL; platelet count, 79,000/μL; total bilirubin, 8.4 mg/dL; direct bilirubin, 6.4 mg/dL; aspartate aminotransferase, 145 U/L; alanine aminotransferase, 45 U/L; alkaline phosphatase, 596 U/L; albumin, 2.9 mg/dL; prothrombin time (PT) (%), 30%; free triiodothyronine, 30.1 pg/mL; free thyroxine > 7.77 ng/dL; thyroid-stimulating hormone, < 0.005 μIU/mL; and anti-thyroid-stimulating hormone receptor antibodies, 29.8 IU/mL. Antithyroglobulin and antithyroid peroxidase antibodies were absent. The creatine kinase levels were not elevated. An arterial blood gas analysis on arrival revealed the following: pH, 7.275; pO2, 317 mmHg (fraction of inspiratory oxygen of 1.0); pCO2, 29.5 mmHg; HCO3−, 13.3 mmol/L; base excess, − 12.1 mmol/L; and lactate, 7.4 mmol/L. Serological tests for hepatitis A/B/C, antinuclear antibodies, anti-mitochondrial antibodies, anti-gliadin antibodies, and HIV were negative. The diagnosis was thyroid storm due to Graves’ disease and multi-organ dysfunction, acute liver failure, acute heart failure, acute respiratory failure, acute renal failure, disseminated intravascular coagulation, and disturbance of consciousness. She was admitted to the intensive-care unit (ICU).

During the acute course, the patient received an anti-thyroid drug and underwent therapeutic plasma exchange (TPE) under veno-arterial ECMO. The ECMO duration was 5 days. Although her thyroid function improved, her serum total bilirubin level continued to increase to 38 mg/dl until 8 days after her admission. At this timing, the liver transplant team intervened. Plasma exchange, which was performed twice, improved her bilirubin level, but after TPE it increased continuously to 30 mg/dl again. The patient underwent total thyroidectomy to manage her thyroid function. The operative time was 3 h 25 min. Blood loss was 1290 mL due to inflammation and coagulopathy. Intraoperative transfusion required 4 units of red blood cells, 8 units of fresh frozen plasma, and 10 units of platelets.

On postoperative day 3, cervical swelling appeared and hemostasis was needed. Thyroidectomy reduced her thyroid hormone levels, but her bilirubin level increased to 30 mg/dl and her PT was < 40%. While the patient was under intensive care for multi-organ failure caused by thyroid storm, and her circulation and respiration were gradually improving, liver failure was observed to be progressing. Although liver failure was considered a possible prognostic factor, liver transplantation was not considered feasible in the presence of multiple organ failure and DIC, even though the patient was improving. As a life-saving measure, it was considered important to perform liver transplantation without missing the timing when the conditions of multiple organ failure and DIC improved. Although brain-dead-donor liver transplantation was considered, it was difficult to register the patient when multiple organ dysfunction was present as well. We, therefore, planned to perform LDLT as soon as the patient's condition improved while conducting an evaluation of her husband, who was willing to become a donor, simultaneously with intensive care.

Her respiration and circulation gradually stabilized under mechanical ventilation, sedation, and a low vasopressor dose. The symptoms were disturbance of consciousness, renal failure, and liver failure. Her consciousness level gradually improved to GCS 10 after tracheostomy. There were no findings of post-resuscitation encephalopathy on magnetic resonance imaging or electroencephalography. Based on these objective findings, the neurologists concluded that the patient’s consciousness was reversible. Her renal failure was controlled stably under continuous hemodiafiltration, and it was possible to switch to intermittent hemodialysis with the expectation of discontinuing dialysis. However, the patient’s liver failure deteriorated. Her Child–Pugh score was 11 with a classification of C, and her model for end-stage liver disease score was 38. Registration as a recipient for deceased-donor liver transplantation was not recommended by the committee because of the expected poor outcome after liver transplantation owing to her severe general condition with multiple organ dysfunction. Since we considered the recovery of her liver function to be mandatory for improving her general status, we decided to perform LDLT as a life-saving treatment. The clinical course of the patient is shown in Fig. 1.

Clinical course from admission to living donor liver transplantation. CHDF: continuous hemodiafiltration; VA-ECMO: veno-arterial extracorporeal membrane oxygenation; TPE: therapeutic plasma exchange; T.Bil: total bilirubin; AST: aspartate transaminase; ALT: alanine aminotransferase; PT: prothrombin time; Plt: platelet; FT3: free triiodo thyronine; FT4: free thyroxine

The patient underwent LDLT with a partial liver graft from her husband, whose blood type was A (identical to her blood type) on day 31 of admission. Based on preoperative volumetry, a right lobe graft was transplanted. The weight of the graft was 766 g. The graft weight/recipient standard liver volume ratio was 60.6%. The cold ischemic time was 56 min, and the warm ischemic time was 4 min, with 43 min for anastomosis. Intraoperatively, ischemic change, thought to be caused by shock, catecholamine use, and use of ECMO and continuous hemodiafiltration, was found at the terminal ileum to the ascending colon after the opening of abdomen and worsened during the surgery. Right hemicolectomy was performed after reconstruction of the hepatic artery. Considering the influence of further invasiveness on her general condition, we finished the operation without biliary reconstruction under open abdominal management. Biliary reconstruction was planned to be performed after the patient’s general condition had been stabilized by intensive care. The total operative time was 767 min, and blood loss during the whole operation was 3875 g.

Bile duct reconstruction was performed on post-operative day (POD) 2 as a secondary procedure. The extracted liver weighed 800 g and exhibited a diffuse brown–green color change. A histological examination revealed acute chronic changes. Bile thrombi were found in the centrilobular bile canaliculi, and hepatocytes and Kupffer cells showed pigmentation with a high degree of hepatocyte necrosis and neutrophil infiltration, indicating significant acute changes. In addition, there were chronic findings, such as enlargement of the bile canaliculi, fibrosis in the portal and periportal regions, enlargement of hepatocytes mainly in the peripheral region, and Mallory–Denk body formation, suggesting that the liver with thyroid hormone-induced chronic hepatitis and chronic bile congestion had changed acutely due to thyroid crisis. No evidence of liver cirrhosis was found.

Regarding immune suppression therapy, methylprednisolone and basiliximab were administered, given her renal failure. However, the patient’s condition was complicated by acute cellular rejection, intra-abdominal hemorrhaging, and colonic hemorrhaging. A sharp increase in liver enzymes was observed on POD 9, so a liver biopsy was performed with suspicion of rejection. A histological examination revealed a diagnosis of acute cellular rejection, and the patient was treated with steroid pulse therapy and a continuous infusion of the tacrolimus, resulting in improvement. The trough value of tacrolimus was controlled at around 15 ng/ml. At the time of the liver biopsy, the intercostal artery was injured, which was complicated by intra-abdominal bleeding on POD 15; therefore, emergency laparotomy for hemostasis was performed. Gastrointestinal hemorrhaging was observed on POD 23, and ischemic colitis was diagnosed via endoscopy. After conservative treatment, the ischemic colitis improved, but bleeding occurred again on POD 53, and transcatheter arterial embolization of the inferior mesenteric artery was performed to achieve hemostasis. After these complications, the patient’s liver function and general condition gradually improved. The clinical course after liver transplantation is shown in Fig. 2.

Clinical course from living donor liver transplantation to discharge. CHDF: continuous hemodiafiltration; ICU: intensive care unit,

Two years after LDLT, other than the need for intermittent hemodialysis, the patient is in good condition with a normal liver function and lives her daily life. In addition, the donor’s postoperative course was uneventful. The patient was discharged on POD 10.