All human and (animal studies) that were performed, and which forms the basis for the arguments in this manuscript were approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All study participants gave their informed consent prior to their inclusion in those studies. However, the actual manuscript does not contain clinical studies or patient data.

There were no corporate or commercial relationships that might pose a conflict of interest related to the preparation of this manuscript, e.g., no relationships with pharmaceutical or device companies, no consultantships, honoraria, stock ownership, gifts, free or reimbursed travel/vacations, equity interests, arrangements regarding patents or other vested interests.