adenosine (in RNA) and deoxyadenosine (in DNA)

mutations in DNA at A exceed mutations at T

adenosine to inosine RNA editing

adenosine deaminase acting on RNA

apolipoprotein B mRNA-editing, catalytic polypeptide

activation-induced deaminase

apurinic/apyrimidinic endonuclease

cytidine (in RNA) and deoxcytidine (in DNA)

catalogue of somatic mutations in cancer (https://cancer.sanger.ac.uk/cosmic/signatures)

mutations in DNA at G exceed mutations at C

nucleotide excision repair

next generation sequencing

non-transcribed strand

proliferating cell nuclear antigen

polymerase chain reaction

purine base (e.g., A and G)

single base substitution

target site reverse transcription

weak (W) base (e.g., A and T)

pyrimidine base (e.g., C and T)

Somatic hypermutation

Strand biased mutations

Immunoglobulin (Ig) Genes

TP53

DNA Polymerase-eta

DNA Polymerase-theta

Reverse transcriptase

PCR recombinant artefacts

This is a historical Perspective review of previous published data

© 2023 The Author(s). Published by Elsevier B.V.