Newton, K. & Dixit, V. M. Signaling in innate immunity and inflammation. Cold Spring Harb. Perspect. Biol. 4, a006049 (2012).
Article PubMed PubMed Central Google Scholar
Meissner, F., Scheltema, R. A., Mollenkopf, H. J. & Mann, M. Direct proteomic quantification of the secretome of activated immune cells. Science 340, 475–478 (2013).
Article CAS PubMed Google Scholar
Broz, P. & Dixit, V. M. Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16, 407–420 (2016).
Article CAS PubMed Google Scholar
Lamkanfi, M. & Dixit, V. M. Mechanisms and functions of inflammasomes. Cell 157, 1013–1022 (2014).
Article CAS PubMed Google Scholar
Paerewijck, O. & Lamkanfi, M. The human inflammasomes. Mol. Asp. Med. 88, 101100 (2022).
Kayagaki, N. et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666–671 (2015). This report describes the identification of GSDMD as an essential effector of pyroptosis and IL-1β release.
Article CAS PubMed Google Scholar
Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660–665 (2015). This report describes the identification of GSDMD as an essential effector of pyroptosis and IL-1β release.
Article CAS PubMed Google Scholar
He, W. T. et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 25, 1285–1298 (2015).
Article CAS PubMed PubMed Central Google Scholar
Aglietti, R. A. et al. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc. Natl Acad. Sci. USA 113, 7858–7863 (2016).
Article CAS PubMed PubMed Central Google Scholar
Ding, J. et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111–116 (2016).
Article CAS PubMed Google Scholar
Liu, X. et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535, 153–158 (2016).
Article CAS PubMed PubMed Central Google Scholar
Sborgi, L. et al. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 35, 1766–1778 (2016).
Article CAS PubMed PubMed Central Google Scholar
Lamkanfi, M. et al. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J. Immunol. 185, 4385–4392 (2010).
Article CAS PubMed Google Scholar
Kayagaki, N. et al. NINJ1 mediates plasma membrane rupture during lytic cell death. Nature 591, 131–136 (2021). This paper demonstrates that pyroptotic cell lysis is a controlled event regulated by NINJ1.
Article CAS PubMed Google Scholar
Nadkarni, R. et al. Viral proteases activate the CARD8 inflammasome in the human cardiovascular system. J. Exp. Med. 219, e0212117 (2022).
Su, S. et al. Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages. Cell 175, 442–457 e423 (2018).
Article CAS PubMed Google Scholar
Kumari, P., Russo, A. J., Shivcharan, S. & Rathinam, V. A. AIM2 in health and disease: inflammasome and beyond. Immunol. Rev. 297, 83–95 (2020).
Article CAS PubMed PubMed Central Google Scholar
Fidler, T. P. et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature 592, 296–301 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zhou, J. Y. et al. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc. Natl Acad. Sci. USA 120, e2213777120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Gaidt, M. M. et al. The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3. Cell 171, 1110–1124 e1118 (2017).
Article CAS PubMed PubMed Central Google Scholar
Munoz-Planillo, R. et al. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38, 1142–1153 (2013).
Article CAS PubMed PubMed Central Google Scholar
Gross, C. J. et al. K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity 45, 761–773 (2016).
Article CAS PubMed Google Scholar
Gaidt, M. M. et al. Human monocytes engage an alternative inflammasome pathway. Immunity 44, 833–846 (2016).
Article CAS PubMed Google Scholar
Bauernfeind, F. G. et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787–791 (2009).
Article CAS PubMed Google Scholar
McKee, C. M. & Coll, R. C. NLRP3 inflammasome priming: a riddle wrapped in a mystery inside an enigma. J. Leukoc. Biol. 108, 937–952 (2020).
Article CAS PubMed Google Scholar
He, Y., Zeng, M. Y., Yang, D., Motro, B. & Nunez, G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530, 354–357 (2016).
Article CAS PubMed PubMed Central Google Scholar
Shi, H. et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat. Immunol. 17, 250–258 (2016).
Article CAS PubMed Google Scholar
Schmid-Burgk, J. L. et al. A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. J. Biol. Chem. 291, 103–109 (2016).
Article CAS PubMed Google Scholar
Netea, M. G. et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113, 2324–2335 (2009).
Article CAS PubMed PubMed Central Google Scholar
O’Brien, M. et al. A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells. J. Immunol. methods 447, 1–13 (2017).
Santos, J. C. et al. Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nat. Commun. 11, 3276 (2020).
Article CAS PubMed PubMed Central Google Scholar
Shi, J. et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514, 187–192 (2014).
Article CAS PubMed Google Scholar
Kayagaki, N. et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341, 1246–1249 (2013).
Article CAS PubMed Google Scholar
Knodler, L. A. et al. Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe 16, 249–256 (2014).
Article CAS PubMed PubMed Central Google Scholar
Andreeva, L. et al. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell 184, 6299–6312 e6222 (2021).
Article CAS PubMed PubMed Central Google Scholar
Dekker, C. et al. Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition. J. Mol. Biol. 433, 167309 (2021).
Article CAS PubMed Google Scholar
Hochheiser, I. V. et al. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature 604, 184–189 (2022). Report of a cryo-EM structure of full-length human NLRP3 bound to an NLRP3 inhibitor.
Comments (0)