Rizen EN, Phan AT. Neuroendocrine tumors: a relevant clinical update. Curr Oncol Rep. 2022;24(6):703–14. https://doi.org/10.1007/s11912-022-01217-z.
Article CAS PubMed Google Scholar
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3(10):1335–42. https://doi.org/10.1001/jamaoncol.2017.0589.
Article PubMed PubMed Central Google Scholar
Oronsky B, Ma PC, Morgensztern D, Carter CA. Nothing but NET: a review of neuroendocrine tumors and carcinomas. Neoplasia (New York, NY). 2017;19(12):991–1002. https://doi.org/10.1016/j.neo.2017.09.002.
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (New York, NY). 2011;331(6021):1199–203. https://doi.org/10.1126/science.1200609.
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, et al. Overview of the 2022 WHO classification of neuroendocrine neoplasms. Endocr Pathol. 2022;33(1):115–54. https://doi.org/10.1007/s12022-022-09708-2.
Article CAS PubMed Google Scholar
Aluri V, Dillon JS. Biochemical testing in neuroendocrine tumors. Endocrinol Metab Clin N Am. 2017;46(3):669–77. https://doi.org/10.1016/j.ecl.2017.04.004.
Oberg K, Modlin IM, De Herder W, Pavel M, Klimstra D, Frilling A, et al. Consensus on biomarkers for neuroendocrine tumour disease. Lancet Oncol. 2015;16(9):e435–46. https://doi.org/10.1016/s1470-2045(15)00186-2.
Article CAS PubMed PubMed Central Google Scholar
Ciobanu OA, Martin S, Fica S. Perspectives on the diagnostic, predictive and prognostic markers of neuroendocrine neoplasms (Review). Exp Ther Med. 2021;22(6):1479. https://doi.org/10.3892/etm.2021.10914.
Article CAS PubMed PubMed Central Google Scholar
Herrera-Martínez AD, Hofland LJ, Gálvez Moreno MA, Castaño JP, de Herder WW, Feelders RA. Neuroendocrine neoplasms: current and potential diagnostic, predictive and prognostic markers. Endocr Relat Cancer. 2019;26(3):R157-r79. https://doi.org/10.1530/erc-18-0354.
Article CAS PubMed Google Scholar
Modlin IM, Kidd M, Malczewska A, Drozdov I, Bodei L, Matar S, et al. The NETest: the clinical utility of multigene blood analysis in the diagnosis and management of neuroendocrine tumors. Endocr Metab Clin N Am. 2018;47(3):485–504. https://doi.org/10.1016/j.ecl.2018.05.002.
Malczewska A, Kos-Kudła B, Kidd M, Drozdov I, Bodei L, Matar S, et al. The clinical applications of a multigene liquid biopsy (NETest) in neuroendocrine tumors. Adv Med Sci. 2020;65(1):18–29. https://doi.org/10.1016/j.advms.2019.10.002.
Article CAS PubMed Google Scholar
• Boons G, Vandamme T, Mariën L, Lybaert W, Roeyen G, Rondou T, et al. Longitudinal copy-number alteration analysis in plasma cell-free DNA of neuroendocrine neoplasms is a novel specific biomarker for diagnosis, prognosis, and follow-up. Cli Cancer Res. 2022;28(2):338–49. https://doi.org/10.1158/1078-0432.ccr-21-2291. This paper reveals that the CNA patterns in the cfDNA of NEN patients could serve as a novel, highly specific biomarker.
Marotta V, Zatelli MC, Sciammarella C, Ambrosio MR, Bondanelli M, Colao A, et al. Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame. Endocri Relat Cancer. 2018;25(1):R11-r29. https://doi.org/10.1530/erc-17-0269.
Matar S, Malczewska A, Oberg K, Bodei L, Aslanian H, Lewczuk-Myślicka A, et al. Blood chromogranin A is not effective as a biomarker for diagnosis or management of bronchopulmonary neuroendocrine tumors/neoplasms. Neuroendocrinology. 2020;110(3–4):185–97. https://doi.org/10.1159/000500202.
Article CAS PubMed Google Scholar
Bajetta E, Ferrari L, Martinetti A, Celio L, Procopio G, Artale S, et al. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer. 1999;86(5):858–65. https://doi.org/10.1002/(sici)1097-0142(19990901)86:5%3c858::aid-cncr23%3e3.0.co;2-8.
Article CAS PubMed Google Scholar
Nobels FR, Kwekkeboom DJ, Coopmans W, Schoenmakers CH, Lindemans J, De Herder WW, et al. Chromogranin A as serum marker for neuroendocrine neoplasia: comparison with neuron-specific enolase and the alpha-subunit of glycoprotein hormones. J Clin Endocrinol Metab. 1997;82(8):2622–8. https://doi.org/10.1210/jcem.82.8.4145.
Article CAS PubMed Google Scholar
Baudin E, Gigliotti A, Ducreux M, Ropers J, Comoy E, Sabourin JC, et al. Neuron-specific enolase and chromogranin A as markers of neuroendocrine tumours. Br J Cancer. 1998;78(8):1102–7. https://doi.org/10.1038/bjc.1998.635.
Article CAS PubMed PubMed Central Google Scholar
Panzuto F, Severi C, Cannizzaro R, Falconi M, Angeletti S, Pasquali A, et al. Utility of combined use of plasma levels of chromogranin A and pancreatic polypeptide in the diagnosis of gastrointestinal and pancreatic endocrine tumors. J Endocrinol Invest. 2004;27(1):6–11. https://doi.org/10.1007/bf03350903.
Article CAS PubMed Google Scholar
Walter T, Chardon L, Chopin-laly X, Raverot V, Caffin AG, Chayvialle JA, et al. Is the combination of chromogranin A and pancreatic polypeptide serum determinations of interest in the diagnosis and follow-up of gastro-entero-pancreatic neuroendocrine tumours? Eur J Cancer (Oxford, England : 1990). 2012;48(12):1766–73. https://doi.org/10.1016/j.ejca.2011.11.005.
Chauhan A, Prieur A, Kolesar J, Arnold S, Payen L, Mahi Y, et al. hPG(80) (circulating progastrin), a novel blood-based biomarker for detection of poorly differentiated neuroendocrine carcinoma and well differentiated neuroendocrine tumors. Cancers. 2022;14(4). https://doi.org/10.3390/cancers14040863.
Öberg K, Califano A, Strosberg JR, Ma S, Pape U, Bodei L, et al. A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood. Ann Oncol. 2020;31(2):202–12. https://doi.org/10.1016/j.annonc.2019.11.003.
Fang JM, Li J, Shi J. An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms. World J Gastroenterol. 2022;28(10):1009–23. https://doi.org/10.3748/wjg.v28.i10.1009.
Article CAS PubMed PubMed Central Google Scholar
Rizzo FM, Meyer T. Liquid biopsies for neuroendocrine tumors: circulating tumor cells, DNA, and microRNAs. Endocr Metab Clin N Am. 2018;47(3):471–83. https://doi.org/10.1016/j.ecl.2018.04.002.
Mader S, Pantel K. Liquid biopsy: current status and future perspectives. Oncol Res Treat. 2017;40(7–8):404–8. https://doi.org/10.1159/000478018.
Article CAS PubMed Google Scholar
Hofland J, Zandee WT, de Herder WW. Role of biomarker tests for diagnosis of neuroendocrine tumours. Nat Rev Endocrinol. 2018;14(11):656–69. https://doi.org/10.1038/s41574-018-0082-5.
Article CAS PubMed Google Scholar
Kanakis G, Kaltsas G. Biochemical markers for gastroenteropancreatic neuroendocrine tumours (GEP-NETs). Best Pract Res Clin Gastroenterol. 2012;26(6):791–802. https://doi.org/10.1016/j.bpg.2012.12.006.
Article CAS PubMed Google Scholar
Oberg K, Couvelard A, Delle Fave G, Gross D, Grossman A, Jensen RT, et al. ENETS consensus guidelines for standard of care in neuroendocrine tumours: biochemical markers. Neuroendocrinology. 2017;105(3):201–11. https://doi.org/10.1159/000472254.
Article CAS PubMed Google Scholar
Niederle B, Pape UF, Costa F, Gross D, Kelestimur F, Knigge U, et al. ENETS consensus guidelines update for neuroendocrine neoplasms of the jejunum and ileum. Neuroendocrinology. 2016;103(2):125–38. https://doi.org/10.1159/000443170.
Article CAS PubMed Google Scholar
Boudreaux JP, Klimstra DS, Hassan MM, Woltering EA, Jensen RT, Goldsmith SJ, et al. The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the jejunum, ileum, appendix, and cecum. Pancreas. 2010;39(6):753–66. https://doi.org/10.1097/MPA.0b013e3181ebb2a5.
Rehfeld JF, Broedbaek K, Goetze JP, Knigge U, Hilsted LM. True chromogranin A concentrations in plasma from patients with small intestinal neuroendocrine tumours. Scand J Gastroenterol. 2020;55(5):565–73. https://doi.org/10.1080/00365521.2020.1759141.
Article CAS PubMed Google Scholar
Erickson JA, Chiang FI, Walker CM, Genzen JR, Doyle K. Comparison of two chromogranin A assays and investigation of nonlinear specimens. Pract Lab Med. 2022;32: e00299. https://doi.org/10.1016/j.plabm.2022.e00299.
Article CAS PubMed PubMed Central Google Scholar
Modlin IM, Oberg K, Taylor A, Drozdov I, Bodei L, Kidd M. Neuroendocrine tumor biomarkers: current status and perspectives. Neuroendocrinology. 2014;100(4):265–77. https://doi.org/10.1159/000368363.
Article CAS PubMed Google Scholar
Hofland J, Kaltsas G, de Herder WW. Advances in the diagnosis and management of well-differentiated neuroendocrine neoplasms. Endocr Rev. 2020;41(2):371–403. https://doi.org/10.1210/endrev/bnz004.
Article PubMed PubMed Central Google Scholar
Roll W, Weckesser M, Seifert R, Bodei L, Rahbar K. Imaging and liquid biopsy in the prediction and evaluation of response to PRRT in neuroendocrine tumors: implications for patient management. Eur J Nucl Med Mol Imaging. 2021;48(12):4016–27. https://doi.org/10.1007/s00259-021-05359-3.
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