Tsuda K. Red blood cell abnormalities and hypertension. Hypertens Res. 2020;43:72–3.

Article  PubMed  Google Scholar 

Tsuda K, Kimura K, Nishio I, Masuyama Y. Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation. Biochem Biophys Res Commun. 2000;275:946–54.

Article  CAS  PubMed  Google Scholar 

Leo F, Suvorava T, Heuser SK, Li J, LoBue A, Barbarino F, et al. Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure. Circulation. 2021;44:870–89.

Article  Google Scholar 

Gang L, Yanyan Z, Zhongwei Z, Juan D. Association between mean platelet volume and hypertension incidence. Hypertens Res. 2017;40:779–84.

Article  PubMed  Google Scholar 

Friedman GD, Selby JV, Quesenberry CP Jr. The leukocyte count: a predictor of hypertension. J Clin Epidemiol. 1990;43:907–11.

Article  CAS  PubMed  Google Scholar 

Gillum RF, Mussolino ME. White blood cell count and hypertension incidence. The NHANES I Epidemiologic Follow-up Study. J Clin Epidemiol. 1994;47:911–9.

Article  CAS  PubMed  Google Scholar 

Sun YT, Gong Y, Zhu R, Liu X, Zhu Y, Wang Y, et al. Relationship between white blood cells and hypertension in Chinese adults: the Cardiometabolic Risk in Chinese (CRC) study. Clin Exp Hypertens. 2015;37:594–8.

Article  PubMed  Google Scholar 

Nakanishi N, Sato M, Shirai K, Suzuki K, Tatara K. White blood cell count as a risk factor for hypertension; a study of Japanese male office workers. J Hypertens. 2002;20:851–7.

Article  CAS  PubMed  Google Scholar 

Shankar A, Klein BE, Klein R. Relationship between white blood cell count and incident hypertension. Am J Hypertens. 2003;17:233–9.

Article  Google Scholar 

Orakzai RH, Otakzai SH, Nasir K, Santos RD, Rana JS, Pimentel I, et al. Association of white blood cell count with systolic blood pressure within the normotensive range. J Hum Hypertens. 2006;20:341–7.

Article  CAS  PubMed  Google Scholar 

Ishida S, Kondo S, Funakoshi S, Satoh A, Maeda T, Kawazoe M, et al. White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study. PLoS One. 2021;16:e0246304.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schillaci G, Pirro M, Pucci G, Ronti T, Vaudo G, Mannarino MR, et al. Prognostic value of elevated white blood cell count in hypertension. Am J Hypertens. 2007;20:364–9.

Article  PubMed  Google Scholar 

Mansoori A, Gohari NSF, Etemad L, Poudineh M, Ahari RK, Mohammadyari F, et al. White blood cell and platelet distribution widths are associated with hypertension: data mining approaches. Hypertens Res. (2023). https://doi.org/10.1038/s41440-023-01472-y.

Ghayour-Mobarhan M, Moohebati M, Esmaily H, Ebrahimi M, Parizadeh SMR, Heidari-Bakavoli AR, et al. Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation. Int J Public Health. 2015;60:561–72.

Article  PubMed  Google Scholar 

Tatsukawa Y, Hsu WL, Yamada M, Cologne JB, Suzuki G, Yamamoto H, et al. White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res. 2008;31:1391–7.

Article  PubMed  Google Scholar 

Liu X, Zhang Q, Wu H, Du H, Liu L, Shi H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension. Am J Hypertens. 2015;28:1339–46.

Article  CAS  PubMed  Google Scholar 

Sarejloo S, Dehesh M, Fathi M, Khanzadeh M, Lucke-Wold B, Ghaedi A, et al. Meta-analysis of differences in neutrophil to lymphocyte ratio between hypertensive and non-hypertensive individuals. BMC Cardiovasc Disord. 2023;23:283.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Demir M. The relationship between neutrophil lymphocyte ratio and non-dipper hypertension. Clin Exp Hypertens. 2013;35:570–3.

Article  CAS  PubMed  Google Scholar 

Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014;234:206–13.

Article  CAS  PubMed  Google Scholar 

Balta S, Celik T, Mikhailidis DP, Ozturk C, Demirkol S, Aparci M, et al. The relation between atherosclerosis and the neutrophil-lymphocyte ratio. Clin Appl Thromb Hemost. 2016;22:405–411.

Article  CAS  PubMed  Google Scholar 

Siedlinski M, Josefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, et al. White blood cells and blood pressure: A Mendelian randomization study. Circulation. 2020;141:1307–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kresovich JK, Xu Z, O’Brien KM, Parks CG, Weinberg CR, Sandler DP, et al. Peripheral immune cell composition is altered in women before and after a hypertension diagnosis. Hypertension. 2023;80:43–53.

Article  CAS  PubMed  Google Scholar 

Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation. 2002;106:1439–41.

Article  CAS  PubMed  Google Scholar 

Lloyd-Jones DM, Liu K, Tian L, Greenland P. Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease. Ann Intern Med. 2006;145:35–42.

Article  CAS  PubMed  Google Scholar 

Elkind MS, Sciacca RR, Boden-Albala B, Tondella ML, Feikin DR, Fields BS, et al. Leukocyte count is associated with reduced endothelial reactivity. Atherosclerosis. 2005;181:329–38.

Article  CAS  PubMed  Google Scholar 

Jia B, Jiang C, Song Y, Duan C, Liu L, Liu C, et al. Association between white blood cell counts and brachial-ankle pulse wave velocity in Chinese hypertensive adults: a cross-sectional study. Angiology. 2022;73:42–50.

Article  CAS  PubMed  Google Scholar 

Huang M, Li F, Chen S, Liu M, Qin W, Wu J, et al. Total white blood cell count is associated with arterial stiffness among hypertensive patients. Angiology. 2023;74:657–63.

Article  CAS  PubMed  Google Scholar 

Told R, Fuchsjäger-Mayrl G, Wolzt M, Schmetterer L, Garhöfer G. Effects of increased white blood cell count on endothelin-induced vasoconstriction in healthy subjects. Exp Eye Res. 2012;97:49–54.

Article  CAS  PubMed  Google Scholar 

Fan F, Jia J, Li J, Huo Y, Zhang Y. White blood cell count predicts the odds of kidney function decline in a Chinese community-based population. BMC Nephrol. 2017;18:190.

Article  PubMed  PubMed Central  Google Scholar 

Kishimoto S, Maruhashi T, Kajikawa M, Harada T, Yamaji T, Han Y, et al. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation. Sci Rep. 2022;12:8201.

Article  CAS  PubMed  PubMed Central  Google Scholar