Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions

Abdelgawad M et al (2021) Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects. Stem Cell Res Ther 12(1):1–20

Article  Google Scholar 

Aboudehen K (2020) Regulation of mTOR signaling by long non-coding RNA. Biochim Biophys Acta (BBA)-Gene Regul Mech 1863(4):194449

Article  CAS  Google Scholar 

Akers JC et al (2013) Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 113(1):1–11

Article  PubMed  PubMed Central  Google Scholar 

Arya SB et al (2022) Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation. Nat Cell Biol 24(7):1019–1028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asgari Taei A et al (2022) Paracrine effects of mesenchymal stem cells in ischemic stroke: opportunities and challenges. Mol Neurobiol 59(10):6281–6306

Article  CAS  PubMed  Google Scholar 

Bae KS et al (2011) Neuron-like differentiation of bone marrow-derived mesenchymal stem cells. Yonsei Med J 52(3):401–412

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baguley B (2010) Multiple drug resistance mechanisms in cancer. Mol Biotechnol 46(3):308–316

Article  CAS  PubMed  Google Scholar 

Biswas S et al (2019) Exosomes produced by mesenchymal stem cells drive differentiation of myeloid cells into immunosuppressive M2-polarized macrophages in breast cancer. J Immunol 203(12):3447–3460

Article  CAS  PubMed  Google Scholar 

Blazquez R et al (2014) Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells. Front Immunol 5:556

Article  PubMed  PubMed Central  Google Scholar 

Bliss SA et al (2016) Mesenchymal stem cell–derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow. Can Res 76(19):5832–5844

Article  CAS  Google Scholar 

Bliss SA et al (2016) Mesenchymal stem cell–derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow. Cancer Res 76(19):5832–5844

Article  CAS  PubMed  Google Scholar 

Boelens MC et al (2014) Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell 159(3):499–513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Börger V et al (2017) Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents. Int J Mol Sci 18(7):1450

Article  PubMed  PubMed Central  Google Scholar 

Bruno S et al (2013) Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth. Stem Cells Dev 22(5):758–771

Article  CAS  PubMed  Google Scholar 

Burja B et al (2020) Human mesenchymal stromal cells from different tissues exhibit unique responses to different inflammatory stimuli. Current Res Transl Med 68(4):217–224

Google Scholar 

Buzas EI et al (2014) Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol 10(6):356–364

Article  CAS  PubMed  Google Scholar 

Camussi G et al (2010) Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int 78(9):838–848

Article  CAS  PubMed  Google Scholar 

Caplan AI, Dennis JE (2006) Mesenchymal stem cells as trophic mediators. J Cell Biochem 98(5):1076–1084

Article  CAS  PubMed  Google Scholar 

Charoenviriyakul C et al (2017) Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics. Eur J Pharm Sci 96:316–322

Article  CAS  PubMed  Google Scholar 

Chen TS et al (2011) Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med 9(1):1–10

Article  Google Scholar 

Chen Y et al (2019) Adipose-derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells. Oncol Rep 41(4):2126–2136

CAS  PubMed  PubMed Central  Google Scholar 

Cheng L, Hill AF (2022) Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discovery 21(5):379–399

Article  CAS  PubMed  Google Scholar 

Cheng Q et al (2017) Multiple myeloma-derived exosomes regulate the functions of mesenchymal stem cells partially via modulating miR-21 and miR-146a. Stem Cells Int 2017:9012152

Article  PubMed  PubMed Central  Google Scholar 

Chouaib B et al (2023) Towards the standardization of mesenchymal stem cell secretome-derived product manufacturing for tissue regeneration. Int J Mol Sci 24(16):12594

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chowdhury R et al (2015) Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts. Oncotarget 6(2):715

Article  PubMed  Google Scholar 

Cloutier N et al (2013) The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. EMBO Mol Med 5(2):235–249

Article  CAS  PubMed  Google Scholar 

Cunningham CJ, Redondo-Castro E, Allan SM (2018) The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke. J Cereb Blood Flow Metab 38(8):1276–1292

Article  PubMed  PubMed Central  Google Scholar 

Daneshmandi L et al (2020) Emergence of the stem cell secretome in regenerative engineering. Trends Biotechnol 38(12):1373–1384

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Araujo Farias V et al (2018) Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci. Mol Cancer 17(1):1–12

Article  Google Scholar 

Dejean E et al (2011) Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. Leukemia 25(12):1882–1890

Article  CAS  PubMed  Google Scholar 

Del Fattore A et al (2015) Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells. Expert Opin Biol Therapy 15(4):495–504

Article  Google Scholar 

Ding Y et al (2022) Mesenchymal stem cell-derived exosomes: a promising therapeutic agent for the treatment of liver diseases. Int J Mol Sci 23(18):10972

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong L et al (2018) Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410. Cell Death Dis 9(2):1–13

Article  Google Scholar 

Dong R et al (2019) MSC-derived exosomes-based therapy for peripheral nerve injury: a novel therapeutic strategy. BioMed Res Int 2019:6458237

Article  PubMed  PubMed Central  Google Scholar 

Dong X et al (2020) Exosomes and breast cancer drug resistance. Cell Death Dis 11(11):987

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong B et al (2021) MiRNA-mediated EMT and CSCs in cancer chemoresistance. Exp Hematol Oncol 10(1):1–12

Article  Google Scholar 

Driscoll J, Patel T (2019) The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease. J Gastroenterol 54(9):763–773

Article  PubMed  PubMed Central  Google Scholar 

Du T et al (2014) Microvesicles derived from human Wharton’s jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor. PLoS ONE 9(5):e96836

Article  PubMed  PubMed Central  Google Scholar 

Du L, Tao X, Shen X (2021) Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway. Breast Cancer 28:829–837

Article  PubMed  Google Scholar 

Eterno V et al (2014) Adipose-derived Mesenchymal Stem Cells (ASCs) may favour breast cancer recurrence via HGF/c-Met signaling. Oncotarget 5(3):613

Article  PubMed  Google Scholar 

Feng Y et al (2014) Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS ONE 9(2):e88685

Comments (0)

No login
gif