Gauglitz, G. G., Korting, H. C., Pavicic, T., Ruzicka, T. & Jeschke, M. G. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol. Med. 17, 113–125 (2011).

Article  CAS  PubMed  Google Scholar 

Ud-Din, S. & Bayat, A. new insights on keloids, hypertrophic scars, and striae. Dermatol. Clin. 32, 193–209 (2014).

Article  CAS  PubMed  Google Scholar 

Tan, S., Khumalo, N. & Bayat, A. Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies. Front. Immunol. 10, 1810 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shih, B. & Bayat, A. Genetics of keloid scarring. Arch. Dermatol. Res. 302, 319–339 (2010).

Article  CAS  PubMed  Google Scholar 

Zhang, J. et al. Recent advances in hypertrophic scar. Histol. Histopathol. 33, 27–39 (2018).

PubMed  Google Scholar 

Lee, S.-S., Yosipovitch, G., Chan, Y.-H. & Goh, C.-L. Pruritus, pain, and small nerve fiber function in keloids: a controlled study. J. Am. Acad. Dermatol. 51, 1002–1006 (2004).

Article  PubMed  Google Scholar 

Guest, J. F., Fuller, G. W. & Vowden, P. Cohort study evaluating the burden of wounds to the UK’s National Health Service in 2017/2018: update from 2012/2013. BMJ Open 10, e045253 (2020).

Article  PubMed  PubMed Central  Google Scholar 

International Surgical Outcomes Study Group. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries. Br. J. Anaesth. 117, 601–609 (2016).

Article  Google Scholar 

Rose, J. et al. Estimated need for surgery worldwide based on prevalence of diseases: implications for public health planning of surgical services. Lancet Glob. Health 3, S13–S20 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Amici, J. M. et al. Prevalence of scars: an international epidemiological survey in adults. J. Eur. Acad. Dermatol. Venereol. 36, e799–e800 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Wal, M. B. A. et al. Outcome after burns: an observational study on burn scar maturation and predictors for severe scarring. Wound Repair Regen. 20, 676–687 (2012).

Article  PubMed  Google Scholar 

Zhou, C. et al. Beyond the surface: a deeper look at the psychosocial impacts of acne scarring. Clin. Cosmet. Investig. Dermatol. 16, 731–738 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Liu, S. et al. Keloid: genetic susceptibility and contributions of genetics and epigenetics to its pathogenesis. Exp. Dermatol. 31, 1665–1675 (2022).

Article  CAS  PubMed  Google Scholar 

Liu, R. et al. Risk factors associated with the progression from keloids to severe keloids. Chin. Med. J. 135, 828–836 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ogawa, R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast. Reconstr. Surg. 149, 79e–94e (2022).

Article  CAS  PubMed  Google Scholar 

Ingrasci, G., El-Kashlan, N., Alexis, A. & Yosipovitch, G. Chronic itch in African Americans: an unmet need. Arch. Dermatol. Res. 314, 405–415 (2021).

Article  PubMed  Google Scholar 

Chung, S., Nakashima, M., Zembutsu, H. & Nakamura, Y. Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 87, 563–573 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, Y. et al. NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population. Am. J. Transl. Res. 8, 544–555 (2016).

CAS  PubMed  PubMed Central  Google Scholar 

Wang, H. et al. Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis. Genomics 114, 110403 (2022).

Article  CAS  PubMed  Google Scholar 

Wang, X. et al. Identification and characterization of four immune-related signatures in keloid. Front. Immunol. 13, 942446 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, Y.-Y. et al. Risk of cancer development in patients with keloids. Sci. Rep. 11, 9390–9390 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madu, P. & Kundu, R. V. Follicular and scarring disorders in skin of color: presentation and management. Am. J. Clin. Dermatol. 15, 307–321 (2014).

Article  PubMed  Google Scholar 

Huang, C. & Ogawa, R. Systemic factors that shape cutaneous pathological scarring. FASEB J. 34, 13171–13184 (2020).

Article  CAS  PubMed  Google Scholar 

Ibrahim, N. E., Shaharan, S. & Dheansa, B. Adverse effects of pregnancy on keloids and hypertrophic scars. Cureus 12, e12154 (2020).

PubMed  PubMed Central  Google Scholar 

Noishiki, C., Hayasaka, Y. & Ogawa, R. Sex differences in keloidogenesis: an analysis of 1659 keloid patients in Japan. Dermatol. Ther. 9, 747–754 (2019).

Article  Google Scholar 

Ogawa, R. et al. The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair Regen. 20, 149–157 (2012).

Article  PubMed  Google Scholar 

Wang, J. C., Fort, C. L. & Hom, D. B. Location propensity for keloids in the head and neck. Facial Plast. Surg. Aesthet. Med. 23, 59–64 (2021).

Article  PubMed  Google Scholar 

Arno, A. I., Gauglitz, G. G., Barret, J. P. & Jeschke, M. G. Up-to-date approach to manage keloids and hypertrophic scars: a useful guide. Burns 40, 1255–1266 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Kwon, H.-E., Ahn, H.-J., Jeong, S. J. & Shin, M. K. The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study. Sci. Rep. 11, 23669 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ung, C. Y. et al. Comorbidities of keloid and hypertrophic scars among participants in UK Biobank. JAMA Dermatol. 159, 172–181 (2023).

Article  PubMed  Google Scholar 

Limandjaja, G. C., Niessen, F. B., Scheper, R. J. & Gibbs, S. Hypertrophic scars and keloids: overview of the evidence and practical guide for differentiating between these abnormal scars. Exp. Dermatol. 30, 146–161 (2021).

Article  CAS  PubMed  Google Scholar 

Butzelaar, L., Ulrich, M. M. W., Mink van der Molen, A. B., Niessen, F. B. & Beelen, R. H. J. Currently known risk factors for hypertrophic skin scarring: a review. J. Plast. Reconstr. Aesthet. Surg. 69, 163–169 (2016).

Article  CAS  PubMed  Google Scholar 

Davies, P., Cuttle, L. & Young, A. A scoping review of the methodology used in studies of genetic influences on the development of keloid or hypertrophic scarring in adults and children after acute wounding. Adv. Wound Care 10, 557–570 (2021).

Article  Google Scholar 

Lawrence, J. W., Mason, S. T., Schomer, K. & Klein, M. B. Epidemiology and impact of scarring after burn injury. J. Burn Care Res. 33, 136–146 (2012).

Article  PubMed  Google Scholar 

Korkmaz, H. I. et al. Scar formation from the perspective of complexity science: a new look at the biological system as a whole. J. Wound Care 31, 178–184 (2022).

Article  PubMed  Google Scholar 

Cb, N., Nc, D., Jm, H., M, M. & Jg, W. Burns: pathophysiology of systemic complications and current management. J. Burn Care Res. 38, e469–e481 (2017).

Article  Google Scholar 

WHO. Fact Sheet: Burns. WHO https://www.who.int/en/news-room/fact-sheets/detail/burns (2023).

Spronk, I. et al. Health related quality of life in adults after burn injuries: a systematic review. PLoS ONE 13, e0197507 (2018).

Article  PubMed  PubMed Central  Google Scholar 

van Baar, M. E. in Textbook on Scar Management (eds Téot, L., Mustoe, T. A., Middelkoop, E. & Gauglitz, G. G.) 37–43 (Springer, 2020).

van de Kar, A. L., van Riessen, F., Koolbergen, D. R. & van der Horst, C. M. A. M. Influence of age on scar tissue: a retrospective study on the differences in scar tissue development between children and adults. J. Plast. Reconstr. Aesthet. Surg. 73, 1357–1404 (2020).

PubMed  Google Scholar 

van der Veer, W. M. et al. Potential cellular and molecular causes of hypertrophic scar formation. Burns 35, 15–29 (2009).

Article  PubMed