Armstrong, A. W. & Read, C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323, 1945–1960 (2020). This comprehensive review details the pathogenesis, clinical presentation and diagnostic approach, comorbidities and risk factors, and treatment approach for psoriasis.

Article  CAS  PubMed  Google Scholar 

Armstrong, A. W. et al. Patient perspectives on psoriatic disease burden: results from the Global Psoriasis and Beyond Survey. Dermatology 239, 621–634 (2023).

Article  PubMed  Google Scholar 

Armstrong, A. W. et al. Psoriasis prevalence in adults in the United States. JAMA Dermatol. 157, 940–946 (2021).

Article  PubMed  Google Scholar 

Parisi, R. et al. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ 369, m1590 (2020). This systematic review and meta-analysis applies modelling to generate global, regional and country-specific prevalence estimates for psoriasis.

Article  PubMed  PubMed Central  Google Scholar 

Pérez-Chada, L. M. et al. Patient-reported outcome measures for health-related quality of life in patients with psoriasis: a systematic review. JAMA Dermatol. 160, 550–563 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Telfer, N. R. The role of streptococcal infection in the initiation of guttate psoriasis. Arch. Dermatol. 128, 39 (1992).

Article  CAS  PubMed  Google Scholar 

Mallbris, L. et al. Psoriasis phenotype at disease onset: clinical characterization of 400 adult cases. J. Invest. Dermatol. 124, 499–504 (2005).

Article  CAS  PubMed  Google Scholar 

Ko, H. C., Jwa, S. W., Song, M., Kim, M. B. & Kwon, K. S. Clinical course of guttate psoriasis: long-term follow-up study. J. Dermatol. 37, 894–899 (2010).

Article  PubMed  Google Scholar 

Sbidian, E. et al. Respiratory virus infection triggers acute psoriasis flares across different clinical subtypes and genetic backgrounds. Br. J. Dermatol. 181, 1304–1306 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Navarini, A. A. et al. European consensus statement on phenotypes of pustular psoriasis. J. Eur. Acad. Dermatol. Venereol. 31, 1792–1799 (2017).

Article  CAS  PubMed  Google Scholar 

Choon, S. E. et al. International consensus definition and diagnostic criteria for generalized pustular psoriasis from the International Psoriasis Council. JAMA Dermatol. 160, 758–768 (2024).

Article  PubMed  Google Scholar 

Boyd, A. S. & Menter, A. Erythrodermic psoriasis. J. Am. Acad. Dermatol. 21, 985–991 (1989).

Article  CAS  PubMed  Google Scholar 

Gupta, R., Debbaneh, M. G. & Liao, W. Genetic epidemiology of psoriasis. Curr. Dermatol. Rep. 3, 61–78 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Feng, B. J. et al. Multiple loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5, e1000606 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Johnston, A. et al. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum. Mol. Genet. 22, 1807–1815 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gudjonsson, J. E. & Johnston, A. Current understanding of the genetic basis of psoriasis. Expert. Rev. Clin. Immunol. 5, 433–443 (2009).

Article  CAS  PubMed  Google Scholar 

Dand, N. et al. Psoriasis and genetics. Acta Derm. Venereol. 100, 55–65 (2020).

Article  Google Scholar 

Dand, N. et al. GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. Nat. Commun. 16, 2051 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan, D., Ahn, R., Leslie, S. & Liao, W. Clinical and genetic risk factors associated with psoriatic arthritis among patients with psoriasis. Dermatol. Ther. 8, 593–604 (2018).

Article  Google Scholar 

Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. & Barker, J. Psoriasis. Lancet 397, 1301–1315 (2021).

Article  CAS  PubMed  Google Scholar 

Mrowietz, U., Lauffer, F., Sondermann, W., Gerdes, S. & Sewerin, P. Psoriasis as a systemic disease. Dtsch. Arztebl. Int. 121, 467–472 (2024).

PubMed  PubMed Central  Google Scholar 

World Health Organization. Global report on psoriasis. WHO www.who.int/publications/i/item/global-report-on-psoriasis (2016).

Mease, P. & Goffe, B. S. Diagnosis and treatment of psoriatic arthritis. J. Am. Acad. Dermatol. 52, 1–19 (2005).

Article  PubMed  Google Scholar 

Yeung, H. et al. Psoriasis severity and the prevalence of major medical comorbidity: a population-based study. JAMA Dermatol. 149, 1173–1179 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Armstrong, A. W., Harskamp, C. T., Ledo, L., Rogers, J. H. & Armstrong, E. J. Coronary artery disease in patients with psoriasis referred for coronary angiography. Am. J. Cardiol. 109, 976–980 (2012).

Article  PubMed  Google Scholar 

Armstrong, A. W. et al. Psoriasis and risk of diabetes-associated microvascular and macrovascular complications. J. Am. Acad. Dermatol. 72, 968–977.e2 (2015).

Article  PubMed  Google Scholar 

Armstrong, A. W., Harskamp, C. T. & Armstrong, E. J. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr. Diabetes 2, e54 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armstrong, A. W., Harskamp, C. T. & Armstrong, E. J. Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. J. Am. Acad. Dermatol. 68, 654–662 (2013).

Article  PubMed  Google Scholar 

Gelfand, J. M. et al. Risk of myocardial infarction in patients with psoriasis. JAMA 296, 1735–1741 (2006).

Article  CAS  PubMed  Google Scholar 

Singh, S., Taylor, C., Kornmehl, H. & Armstrong, A. W. Psoriasis and suicidality: a systematic review and meta-analysis. J. Am. Acad. Dermatol. 77, 425–440.e2 (2017).

Article  PubMed  Google Scholar 

Dowlatshahi, E. A., Wakkee, M., Arends, L. R. & Nijsten, T. The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: a systematic review and meta-analysis. J. Invest. Dermatol. 134, 1542–1551 (2014).

Article  PubMed  Google Scholar 

Mansouri, B. et al. Comparison of coronary artery calcium scores between patients with psoriasis and type 2 diabetes. JAMA Dermatol. 152, 1244–1253 (2016).

Article  PubMed  Google Scholar 

Gelfand, J. M. et al. The risk of stroke in patients with psoriasis. J. Invest. Dermatol. 129, 2411–2418 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehta, N. N. et al. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database. Eur. Heart J. 31, 1000–1006 (2010).

Article  PubMed  Google Scholar 

Armstrong, E. J., Harskamp, C. T. & Armstrong, A. W. Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies. J. Am. Heart Assoc. 2, e000062 (2013).