Efficacy and Safety of Probiotics in Geriatric Patients with Constipation: Systematic Review and Meta-Analysis

Rajindrajith S, Devanarayana NM, Crispus Perera BJ, Benninga MA. Childhood constipation as an emerging public health problem. World J Gastroenterol. Aug 14 2016;22(30):6864–75. doi:https://doi.org/10.3748/wjg.v22.i30.6864

Article  PubMed  PubMed Central  Google Scholar 

Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology. Jan 2021;160(1):99–114.e3. doi:https://doi.org/10.1053/j.gastro.2020.04.014

Article  PubMed  Google Scholar 

Abrahamsson H, Antov S, Bosaeus I. Gastrointestinal and colonic segmental transit time evaluated by a single abdominal x-ray in healthy subjects and constipated patients. Scand J Gastroenterol Suppl. 1988;152:72–80. doi:https://doi.org/10.3109/00365528809095938

Article  CAS  PubMed  Google Scholar 

Blake MR, Raker JM, Whelan K. Validity and reliability of the Bristol Stool Form Scale in healthy adults and patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. Oct 2016;44(7):693–703. doi:https://doi.org/10.1111/apt.13746

Article  CAS  PubMed  Google Scholar 

Frank L, Kleinman L, Farup C, Taylor L, Miner P, Jr. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. Sep 1999;34(9):870–7. doi:https://doi.org/10.1080/003655299750025327

Article  CAS  PubMed  Google Scholar 

Emmanuel A, Cools M, Vandeplassche L, Kerstens R. Prucalopride improves bowel function and colonic transit time in patients with chronic constipation: an integrated analysis. Am J Gastroenterol. Jun 2014;109(6):887–94. doi:https://doi.org/10.1038/ajg.2014.74

Article  CAS  PubMed  PubMed Central  Google Scholar 

Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. Apr 2006;130(5):1480–91. doi:https://doi.org/10.1053/j.gastro.2005.11.061

Article  PubMed  Google Scholar 

Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. May 2010;31(9):938–49. doi:https://doi.org/10.1111/j.1365-2036.2010.04273.x

Article  CAS  PubMed  Google Scholar 

An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol. 2005;100 Suppl 1:S1–4. doi:https://doi.org/10.1111/j.1572-0241.2005.50613_1.x

Basilisco G, Coletta M. Chronic constipation: a critical review. Dig Liver Dis. Nov 2013;45(11):886–93. doi:https://doi.org/10.1016/j.dld.2013.03.016

Article  PubMed  Google Scholar 

Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. Mar 1 2007;25(5):599–608. doi:https://doi.org/10.1111/j.1365-2036.2006.03238.x

Article  CAS  PubMed  Google Scholar 

Attaluri A, Jackson M, Valestin J, Rao SS. Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS. Am J Gastroenterol. Jun 2010;105(6):1407–11. doi:https://doi.org/10.1038/ajg.2009.655

Article  PubMed  Google Scholar 

Kamiński M, Skonieczna-Żydecka K, Łoniewski I, Koulaouzidis A, Marlicz W. Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations. Prz Gastroenterol. 2020;15(2):103–118. doi:https://doi.org/10.5114/pg.2019.86747

PubMed  Google Scholar 

Quigley EM. Probiotics in Irritable Bowel Syndrome: The Science and the Evidence. J Clin Gastroenterol. Nov–Dec 2015;49 Suppl 1:S60–4. doi:https://doi.org/10.1097/mcg.0000000000000348

Article  CAS  PubMed  Google Scholar 

Applegate JA, Fischer Walker CL, Ambikapathi R, Black RE. Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children. BMC Public Health. 2013;13 Suppl 3(Suppl 3):S16. doi:https://doi.org/10.1186/1471-2458-13-s3-s16

Article  PubMed  PubMed Central  Google Scholar 

Szajewska H, Canani RB, Guarino A, et al. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children. J Pediatr Gastroenterol Nutr. Mar 2016;62(3):495–506. doi:https://doi.org/10.1097/mpg.0000000000001081

Article  CAS  PubMed  Google Scholar 

Dimidi E, Mark Scott S, Whelan K. Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals. Proc Nutr Soc. Feb 2020;79(1):147–157. doi:https://doi.org/10.1017/s0029665119000934

Article  PubMed  Google Scholar 

Chmielewska A, Szajewska H. Systematic review of randomised controlled trials: probiotics for functional constipation. World J Gastroenterol. Jan 7 2010;16(1):69–75. doi:https://doi.org/10.3748/wjg.v16.i1.69

PubMed  PubMed Central  Google Scholar 

Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. Sep 2011;46(9):1057–64. doi:https://doi.org/10.3109/00365521.2011.584895

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace C, Sinopoulou V, Gordon M, et al. Probiotics for treatment of chronic constipation in children. Cochrane Database Syst Rev. Mar 29 2022;3(3):Cd014257. doi:https://doi.org/10.1002/14651858.CD014257.pub2

PubMed  Google Scholar 

Harris RG, Neale EP, Ferreira I. When poorly conducted systematic reviews and meta-analyses can mislead: a critical appraisal and update of systematic reviews and meta-analyses examining the effects of probiotics in the treatment of functional constipation in children. Am J Clin Nutr. Jul 1 2019;110(1):177–195. doi:https://doi.org/10.1093/ajcn/nqz071

Article  PubMed  Google Scholar 

Yang W, He T, Zhang W, Gu L, Tu R, Liu H. Effectiveness and safety of lactobacilli in children with functional constipation: Study protocol for a meta-analysis and systematic review. Medicine (Baltimore). May 2019;98(20):e15675. doi:https://doi.org/10.1097/md.0000000000015675

Article  PubMed  Google Scholar 

Huang R, Hu J. Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials. Front Cell Infect Microbiol. 2017;7:153. doi:https://doi.org/10.3389/fcimb.2017.00153

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Schoot A, Helander C, Whelan K, Dimidi E. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. Dec 2022;41(12):2759–2777. doi:https://doi.org/10.1016/j.clnu.2022.10.015

Article  CAS  PubMed  Google Scholar 

Zhang C, Jiang J, Tian F, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. Oct 2020;39(10):2960–2969. doi:https://doi.org/10.1016/j.clnu.2020.01.005

Article  PubMed  Google Scholar 

Dimidi E, Christodoulides S, Fragkos KC, Scott SM, Whelan K. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. Oct 2014;100(4):1075–84. doi:https://doi.org/10.3945/ajcn.114.089151

Article  CAS  PubMed  Google Scholar 

Higgins JPT, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, and V. A. Welch.. Cochrane handbook for systematic reviews of interventions.. 2022

Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj. Mar 29 2021;372:n71. doi:https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Bmj. Oct 18 2011;343:d5928. doi:https://doi.org/10.1136/bmj.d5928

Article  PubMed  PubMed Central  Google Scholar 

Li X, Li Y, Guo K, et al. Evidence Based Social Science in China Paper 3: The quality of social science RCTs published from 2000–2020. J Clin Epidemiol. Jan 2022;141:64–73. doi:https://doi.org/10.1016/j.jclinepi.2021.09.014

Article  PubMed  Google Scholar 

Balduzzi S, Rücker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. Nov 2019;22(4):153–160. doi:https://doi.org/10.1136/ebmental-2019-300117

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj. Sep 6 2003;327(7414):557–60. doi:https://doi.org/10.1136/bmj.327.7414.557

Article  PubMed  PubMed Central  Google Scholar 

Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. Apr 2011;64(4):383–94. doi:https://doi.org/10.1016/j.jclinepi.2010.04.026

Article  PubMed  Google Scholar 

Li Y, Cao L, Zhang Z, et al. Reporting and methodological quality of COVID-19 systematic reviews needs to be improved: an evidence mapping. J Clin Epidemiol. Jul 2021;135:17–28. doi:https://doi.org/10.1016/j.jclinepi.2021.02.021

Article  PubMed  PubMed Central  Google Scholar 

Takeda T, Asaoka D, Nojiri S, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. Dec 23 2022;doi:https://doi.org/10.14309/ajg.0000000000002028

Kondo J, Xiao JZ, Shirahata A, et al. Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding. World J Gastroenterol. 2013;19(14):2162–70. doi:https://doi.org/10.3748/wjg.v19.i14.2162

Article  PubMed  PubMed Central 

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