WHO. Cardiovascular Disease Statistics 2019.

European Cardiovascular. Disease Statistics 2017.

Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, Charron P, Corrado D, Dagres N, de Chillou C, Eckardt L, Friede T, Haugaa KH, Hocini M, Lambiase PD, Marijon E, Merino JL, Peichl P, Priori SG, Reichlin T, Schulz-Menger J, Sticherling C, Tzeis S, Verstrael A, Volterrani M, Cikes M, Kirchhof P, Abdelhamid M, Aboyans V, Arbelo E, et al. 2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of Sudden Cardiac Death. Eur Heart J. 2022;43:3997–4126.

Article  PubMed  Google Scholar 

Al-khatib SM, Ackerman MJ, Gillis AM, Bryant WJ, Hlatky MA, Callans DJ, Granger CB, Curtis AB, Hammill SC, Kay GN, Field ME. AHA/ACC/HRS Guideline for management of patients with ventricular arrhythmias and the Prevention of Sudden Cardiac Death. Circulation. 2017;2017:1–186.

Google Scholar 

Ravi V, Poudyal A, Khanal S, Khalil C, Vij A, Sanders D, Larsen T, Trohman RG, Aksu T, Tung R, Santangeli P, Winterfield J, Sharma PS, Huang HD. A systematic review and meta-analysis comparing radiofrequency catheter ablation with medical therapy for ventricular tachycardia in patients with ischemic and non-ischemic cardiomyopathies. J Interv Card Electrophysiol Springer US; 2022.

Martinez BK, Baker WL, Konopka A, Giannelli D, Coleman CI, Kluger J, Cronin EM. Systematic review and meta-analysis of catheter ablation of ventricular tachycardia in Ischemic Heart Disease. Hear Rhythm Elsevier Inc. 2020;17:e206–19.

Article  Google Scholar 

Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, Faddis M, Gleva M, Noheria A, Smith TW, Hallahan D, Rudy Y, Robinson CG. Noninvasive Cardiac Radiation for ablation of ventricular tachycardia. N Engl J Med. 2017;377:2325–36.

Article  PubMed  PubMed Central  Google Scholar 

Robinson CG, Samson PP, Moore KMS, Hugo GD, Knutson N, Mutic S, Goddu SM, Lang A, Cooper DH, Faddis M, Noheria A, Smith TW, Woodard PK, Gropler RJ, Hallahan DE, Rudy Y, Cuculich PS. Phase I/II trial of Electrophysiology-guided noninvasive Cardiac Radioablation for ventricular tachycardia. Circulation. 2019;139:313–21.

Article  PubMed  PubMed Central  Google Scholar 

Mayinger M, Kovacs B, Tanadini-Lang S, Ehrbar S, Wilke L, Chamberlain M, Moreira A, Weitkamp N, Brunckhorst C, Duru F, Steffel J, Breitenstein A, Alkadhi H, Garcia Schueler HI, Manka R, Ruschitzka F, Guckenberger M, Saguner AM, Andratschke N. First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia. Radiother Oncol Elsevier B V. 2020;152:203–7.

Article  CAS  Google Scholar 

Kovacs B, Mayinger M, Schindler M, Steffel J, Andratschke N, Saguner AM. Stereotactic radioablation of ventricular arrhythmias in patients with structural Heart Disease – A systematic review. Radiother Oncol Elsevier Ireland Ltd. 2021;162:132–9.

Article  Google Scholar 

Amino M, Yoshioka K, Furusawa Y, Tanaka S, Kawabe N, Hashida T, Tsukada T, Izumi M, Inokuchi S, Tanabe T, Ikari Y. Inducibility of Ventricular Arrhythmia 1 year following treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction. PACE - Pacing Clin Electrophysiol. 2017;40:379–90.

Article  PubMed  Google Scholar 

Shivkumar K. Catheter ablation of ventricular arrhythmias. Jarcho JA. ed N Engl J Med. 2019;380:1555–64.

Article  Google Scholar 

Zhang DM, Navara R, Yin T, Szymanski J, Goldsztejn U, Kenkel C, Lang A, Mpoy C, Lipovsky CE, Qiao Y, Hicks S, Li G, Moore KMS, Bergom C, Rogers BE, Robinson CG, Cuculich PS, Schwarz JK, Rentschler SL. Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis. Nat Commun Springer US. 2021;12:5558.

Article  CAS  Google Scholar 

Loo BW, Soltys SG, Wang L, Lo A, Fahimian BP, Iagaru A, Norton L, Shan X, Gardner E, Fogarty T, Maguire P, Al-Ahmad A, Zei P. Stereotactic ablative radiotherapy for the treatment of Refractory Cardiac Ventricular Arrhythmia. Circ Arrhythmia Electrophysiol. 2015;8:748–50.

Article  Google Scholar 

van der Ree MH, Blanck O, Limpens J, Lee CH, Balgobind BV, Dieleman EMT, Wilde AAM, Zei PC, de Groot JR, Slotman BJ, Cuculich PS, Robinson CG, Postema PG. Cardiac radioablation—A systematic review. Hear Rhythm Heart Rhythm Society; 2020.

Ji Y, Liu M. The i3 + 3 design for phase I clinical trials. J Clin Oncol. 2019;37:3066–6.

Article  Google Scholar 

Krug D, Blanck O, Andratschke N, Guckenberger M, Jumeau R, Mehrhof F, Boda-Heggemann J, Seidensaal K, Dunst J, Pruvot E, Scholz E, Saguner AM, Rudic B, Boldt L-H, Bonnemeier H. Recommendations regarding cardiac stereotactic body radiotherapy for treatment refractory ventricular tachycardia. Hear Rhythm. 2021;18:2137–45.

Article  Google Scholar 

Mayinger M, Boda-Heggemann J, Mehrhof F, Krug D, Hohmann S, Xie J, Ehrbar S, Kovacs B, Merten R, Grehn M, Zaman A, Fleckenstein J, Kaestner L, Buergy D, Rudic B, Kluge A, Boldt L, Dunst J, Bonnemeier H, Saguner AM, Andratschke N, Blanck O, Schweikard A. Quality Assurance Process for the Fusion of Electroanatomical Mapping and Radiotherapy Planning Imaging Data in Cardiac Radioablation. Phys Imaging Radiat Oncol Phys. Imag. Radiat. Oncol.; 2022.

Blanck O, Buergy D, Vens M, Eidinger L, Zaman A, Krug D, Rudic B, Boda-Heggemann J, Giordano FA, Boldt L-H, Mehrhof F, Budach V, Schweikard A, Olbrich D, König IR, Siebert F-A, Vonthein R, Dunst J, Bonnemeier H. Radiosurgery for ventricular tachycardia: preclinical and clinical evidence and study design for a German multi-center multi-platform feasibility trial (RAVENTA). Clin Res Cardiol Springer Berlin Heidelberg; 2020.

Kovacs B, Mayinger M, Andratschke N, Saguner AM. Stereotactic arrhythmia radioablation: competitor or adjunct to catheter ablation? Eur Heart J 2022;1–3.

Imamura K, Deisher AJ, Dickow J, Rettmann ME, Yasin OZ, Pepin MD, Hohmann S, Konishi H, Suzuki A, Newman LK, Sun X, Kruse JJ, Merrell KW, Herman MG, Foote RL, Packer DL. Early impact of Proton Beam Therapy on Electrophysiological Characteristics in a Porcine Model. Circ Arrhythmia Electrophysiol 2023;1–12.

Volpato G, Compagnucci P, Cipolletta L, Parisi Q, Valeri Y, Carboni L, Giovagnoni A, Russo A, Dello CM. Safety and Efficacy of Stereotactic Arrhythmia Radioablation for the treatment of ventricular tachycardia: a systematic review. Front Cardiovasc Med. 2022;9:1–6.

Article  Google Scholar