•• Bodilsen J, et al. Risk factors for brain abscess: a nationwide, population-based, nested case-control study. Clin Infect Dis. 2020;71(4):1040–6. A population-based study involving 1,384 brain abscess patients revealed major risk factors: neurosurgery (aOR 19.3), congenital heart disease (aOR 15.6), dental infections (aOR 4.61), and ear, nose, and throat infections (aOR 3.81). Among patients, significant associations with brain abscess occurrence included hematological cancer (aOR 8.77), immunomodulating treatments (aOR 5.71), and conditions like diabetes, alcohol abuse, and liver disease.
• Bodilsen J, et al. Clinical features and prognostic factors in adults with brain abscess. Brain. 2023;146(4):1637–47. A study of 485 cases highlighted the increasing incidence of brain abscesses in adults and identified key mortality risk factors, including brain abscess rupture and immunocompromise. The research suggests delaying antibiotics in select cases awaiting neurosurgery within 24 hours and found no increased mortality risk with corticosteroids for brain edema.
Cantiera M, Tattevin P, Sonneville R. Brain abscess in immunocompetent adult patients. Rev Neurol (Paris). 2019;175(7–8):469–74.
Article CAS PubMed Google Scholar
Mendes M, et al. Susceptibility of brain and skin to bacterial challenge. J Neurosurg. 1980;52(6):772–5.
Article CAS PubMed Google Scholar
•• Stebner A, et al. Molecular diagnosis of polymicrobial brain abscesses with 16S-rDNA-based next-generation sequencing. Clin Microbiol Infect. 2021;27(1):76–82. A study utilizing 16S-rRNA-based next-generation sequencing (NGS) to identify bacteria in intracranial abscesses and meningitis samples, aiming to overcome the limitations of culture-based methods and traditional molecular diagnostics in detecting the diverse bacterial causes. Using NGS, 86 bacterial taxa were identified in brain abscesses with Streptococcus intermedius and Fusobacterium nucleatum as the most common. The study underscores the often polymicrobial nature of these infections, detecting up to 16 different bacterial taxa in a single sample, and establishes the MiSeq platform’s effectiveness for metagenomic diagnostics of such severe infections.
Article CAS PubMed Google Scholar
Sonneville R, et al. An update on bacterial brain abscess in immunocompetent patients. Clin Microbiol Infect. 2017;23(9):614–20.
Article CAS PubMed Google Scholar
Brouwer MC, Tunkel AR, van de Beek D. Brain abscess. N Engl J Med. 2014;371(18):1758.
Brouwer MC, van de Beek D. Epidemiology, diagnosis, and treatment of brain abscesses. Curr Opin Infect Dis. 2017;30(1):129–34.
•• Corsini Campioli C et al. Bacterial brain abscess: an outline for diagnosis and management. Am J Med. 2021;134(10):1210–1217. A retrospective review of 247 adults presenting with pyogenic brain abscess between 2009–2020, assessing the diagnostic methods and treatment approaches. Most patients (93.1%) underwent diagnostic brain MRI, and a majority (83%) received combined medical and surgical treatments. Those treated medically only exhibited a higher mortality rate (21.4% vs 6%) and increased neurologic complications. The findings suggest the importance of a combined medical-surgical approach with extended antimicrobial therapy for better outcomes and reducing permanent neurologic deficits.
Corsini Campioli C et al. Clinical presentation, management, and outcomes of patients with brain abscess due to nocardia species. Open Forum Infect Dis. 2021;8(4):ofab067.
Li X, Tronstad L, Olsen I. Brain abscesses caused by oral infection. Endod Dent Traumatol. 1999;15(3):95–101.
Article CAS PubMed Google Scholar
Fischbein CA, et al. Risk factors of brain abscess in patients with congenital heart disease. Am J Cardiol. 1974;34(1):97–102.
Article CAS PubMed Google Scholar
Thompson RL, Cattaneo SM, Barnes J. Recurrent brain abscess: manifestation of pulmonary arteriovenous fistula and hereditary hemorrhagic telangiectasia. Chest. 1977;72(5):654–5.
Article CAS PubMed Google Scholar
Lisboa ECC, et al. The connection between brain abscess and odontogenic infections: a systematic review. Arch Oral Biol. 2022;135: 105360.
Al Masalma M, et al. Metagenomic analysis of brain abscesses identifies specific bacterial associations. Clin Infect Dis. 2012;54(2):202–10.
Article CAS PubMed Google Scholar
Zhou W, Shao X, Jiang X. A clinical report of two cases of cryptogenic brain abscess and a relevant literature review. Front Neurosci. 2018;12:1054.
Jim KK, Brouwer MC, van der Ende A, van de Beek D. Cerebral abscesses in patients with bacterial meningitis. J Infect. 2012;64(2):236–8.
Nelson CA, Zunt JR. Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients. Clin Infect Dis. 2011;53(9):915–26.
Article PubMed PubMed Central Google Scholar
Tan IL, et al. HIV-associated opportunistic infections of the CNS. Lancet Neurol. 2012;11(7):605–17.
Modi M, Mochan A, Modi G. Management of HIV-associated focal brain lesions in developing countries. QJM. 2004;97(7):413–21.
Article CAS PubMed Google Scholar
Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML. Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery. 1994;35(4):622–31.
Article CAS PubMed Google Scholar
Yetmar ZA, et al. Outcomes of nocardiosis and treatment of disseminated infection in solid organ transplant recipients. Transplantation. 2023;107(3):782–91.
Article CAS PubMed Google Scholar
Selby R, et al. Brain abscess in solid organ transplant recipients receiving cyclosporine-based immunosuppression. Arch Surg. 1997;132(3):304–10.
Article CAS PubMed PubMed Central Google Scholar
Alagha R, et al. Volvariella volvacea brain abscess in an immunocompromised host-An emerging fungal pathogen in Asia. J Mycol Med. 2022;32(3):101272.
St John JA, et al. Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis. MBio. 2014;5(2):e00025.
Article PubMed PubMed Central Google Scholar
Chadwick DR, Ang B, Sitoh YY, Lee CC. Cerebral melioidosis in Singapore: a review of five cases. Trans R Soc Trop Med Hyg. 2002;96(1):72–6.
Article CAS PubMed Google Scholar
Ibekwe TS, Nwaorgu OG. Classification and management challenges of otitis media in a resource-poor country. Niger J Clin Pract. 2011;14(3):262–9.
Article CAS PubMed Google Scholar
Wu JF, et al. Extracranial and intracranial complications of otitis media: 22-year clinical experience and analysis. Acta Otolaryngol. 2012;132(3):261–5.
Higuita NA, et al. U.S bound journey of migrant peoples InTransit across Dante’s inferno and purgatory in the Americas. Travel Med Infect Dis. 2022;47:102317.
Dwyer-Lindgren L, et al. Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017. Nature. 2019;570(7760):189–93.
Article CAS PubMed PubMed Central Google Scholar
Osborn MK, Steinberg JP. Subdural empyema and other suppurative complications of paranasal sinusitis. Lancet Infect Dis. 2007;7(1):62–7.
Kichenbrand C, et al. Brain abscesses and intracranial empyema due to dental pathogens: case series. Int J Surg Case Rep. 2020;69:35–8.
Article PubMed PubMed Central Google Scholar
Viswanatha B, Nsaeeruddin K. Conservative management of otogenic brain abscess with surgical management of attico antral ear disease: a review. Indian J Otolaryngol Head Neck Surg. 2012;64(2):113–9.
Article CAS PubMed PubMed Central Google Scholar
Xiao F, et al. Brain abscess: clinical experience and analysis of prognostic factors. Surg Neurol. 2005;63(5):442–9 (discussion 449-50).
Taj S, et al. Infective endocarditis leading to intracranial abscess: a case report and literature review. Cureus. 2021;13(1):e12660.
PubMed PubMed Central Google Scholar
Daoud H, Abugroun A, Olanipekun O, Garrison D. Infective endocarditis and brain abscess secondary to Aggregatibacter aphrophilus. IDCases. 2019;17:e00561.
Article PubMed PubMed Central Google Scholar
Wongwandee M, Linasmita P. Central nervous system melioidosis: a systematic review of individual participant data of case reports and case series. PLoS Negl Trop Dis. 2019;13(4):e0007320.
Article PubMed PubMed Central Google Scholar
Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–18.
Article PubMed PubMed Central Google Scholar
Russo TA and CM Marr. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32(3).
Wu C, Han S, Baydur A, Lindgren B. Klebsiella brain abscess in an immunocompetent patient: a case report. J Med Case Rep. 2021;15(1):44.
Article PubMed PubMed Central Google Scholar
Goralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi. Infection. 2018;46(4):443–59.
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