A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults

Manly JJ, Jones RN, Langa KM, Ryan LH, Levine DA, McCammon R, Heeringa SG, Weir D. Estimating the prevalence of dementia and mild cognitive impairment in the US: the 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project. JAMA Neurol. 2022;79(12):1242–9.

You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021;58(6):671–85.

Article  PubMed  Google Scholar 

Callahan KE, Lovato JF, Miller ME, Easterling D, Snitz B, Williamson JD. Associations between mild cognitive impairment and hospitalization and readmission. J Am Geriatr Soc. 2015;63(9):1880–5.

Article  PubMed  PubMed Central  Google Scholar 

Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Alzheimers Dement. 2021;17(3):327–406.

Luengo-Fernandez R, Leal J, Gray AM. Cost of dementia in the pre-enlargement countries of the European Union. J Alzheimer’s Dis. 2011;27:187–96.

Article  Google Scholar 

Davies G, Marioni RE, Liewald DC, Hill WD, Hagenaars SP, Harris SE, Ritchie SJ, Luciano M, Fawns-Ritchie C, Lyall D, et al. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151). Mol Psychiatry. 2016;21(6):758–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hill WD, Arslan RC, Xia C, Luciano M, Amador C, Navarro P, Hayward C, Nagy R, Porteous DJ, McIntosh AM, et al. Genomic analysis of family data reveals additional genetic effects on intelligence and personality. Mol Psychiatry. 2018;23(12):2347–62.

Article  PubMed  PubMed Central  Google Scholar 

Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63(2):168–74.

Article  PubMed  Google Scholar 

Escott-Price V, Myers A, Huentelman M, Shoai M, Hardy J. Polygenic risk score analysis of Alzheimer’s disease in cases without APOE4 or APOE2 alleles. J Prev Alzheimers Dis. 2019;6(1):16–9.

CAS  PubMed  Google Scholar 

Najar J, van der Lee SJ, Joas E, Wetterberg H, Hardy J, Guerreiro R, Bras J, Waern M, Kern S, Zetterberg H, et al. Polygenic risk scores for Alzheimer’s disease are related to dementia risk in APOE ɛ4 negatives. Alzheimers Dement (Amst). 2021;13(1):e12142.

Article  PubMed  Google Scholar 

Leonenko G, Baker E, Stevenson-Hoare J, Sierksma A, Fiers M, Williams J, de Strooper B, Escott-Price V. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nat Commun. 2021;12(1):4506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tank R, Ward J, Flegal KE, Smith DJ, Bailey MES, Cavanagh J, Lyall DM. Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology. 2022;47(2):564–9.

Article  CAS  PubMed  Google Scholar 

Sofer T, Kurniansyah N, Granot-Hershkovitz E, Goodman MO, Tarraf W, Broce I, Lipton RB, Daviglus M, Lamar M, Wassertheil-Smoller S, et al. PA polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.. Alz Res Therapy. 2023;15:146

Granot-Hershkovitz E, Tarraf W, Kurniansyah N, Daviglus M, Isasi CR, Kaplan R, Lamar M, Perreira KM, Wassertheil-Smoller S, Stickel A, et al. APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL). Alzheimers Dement. 2021;17(3):466–74.

Article  CAS  PubMed  Google Scholar 

Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, et al. Common polygenic variation enhances risk prediction for Alzheimer’s disease. Brain. 2015;138(Pt 12):3673–84.

Article  PubMed  PubMed Central  Google Scholar 

Daunt P, Ballard CG, Creese B, Davidson G, Hardy J, Oshota O, Pither RJ, Gibson AM. Polygenic risk scoring is an effective approach to predict those individuals most likely to decline cognitively due to Alzheimer’s disease. J Prev Alzheimers Dis. 2021;8(1):78–83.

CAS  Google Scholar 

Chaudhury S, Brookes KJ, Patel T, Fallows A, Guetta-Baranes T, Turton JC, Guerreiro R, Bras J, Hardy J, Francis PT, et al. Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment. Transl Psychiatry. 2019;9(1):154.

Article  PubMed  PubMed Central  Google Scholar 

Marden JR, Mayeda ER, Walter S, Vivot A, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM. Using an Alzheimer disease polygenic risk score to predict memory decline in Black and White Americans over 14 years of follow-up. Alzheimer Dis Assoc Disord. 2016;30(3):195–202.

Article  PubMed  PubMed Central  Google Scholar 

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46.

Article  PubMed  PubMed Central  Google Scholar 

Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, Gronseth GS, Marson D, Pringsheim T, Day GS, et al. Practice guideline update summary: mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126–35.

Article  PubMed  PubMed Central  Google Scholar 

Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol. 2014;13(8):788–94.

Article  PubMed  Google Scholar 

Mandolesi L, Polverino A, Montuori S, Foti F, Ferraioli G, Sorrentino P, Sorrentino G. Effects of physical exercise on cognitive functioning and wellbeing: biological and psychological benefits. Front Psychol. 2018;9:509.

Article  PubMed  PubMed Central  Google Scholar 

Liu T, Li H, Colton JP, Ge S, Li C. The BDNF Val66Met polymorphism, regular exercise, and cognition: a systematic review. West J Nurs Res. 2020;42(8):660–73.

Article  PubMed  Google Scholar 

Canivet A, Albinet CT, Andre N, Pylouster J, Rodriguez-Ballesteros M, Kitzis A, Audiffren M. Effects of BDNF polymorphism and physical activity on episodic memory in the elderly: a cross sectional study. Eur Rev Aging Phys Act. 2015;12:15.

Article  PubMed  PubMed Central  Google Scholar 

Thibeau S, McFall GP, Wiebe SA, Anstey KJ, Dixon RA. Genetic factors moderate everyday physical activity effects on executive functions in aging: evidence from the Victoria Longitudinal Study. Neuropsychology. 2016;30(1):6–17.

Article  PubMed  PubMed Central  Google Scholar 

Watts A, Andrews SJ, Anstey KJ. Sex differences in the impact of BDNF genotype on the longitudinal relationship between physical activity and cognitive performance. Gerontology. 2018;64:361–72.

Article  CAS  PubMed  Google Scholar 

Erickson KI, Banducci SE, Weinstein AM, Macdonald AW 3rd, Ferrell RE, Halder I, Flory JD, Manuck SB. The brain-derived neurotrophic factor Val66Met polymorphism moderates an effect of physical activity on working memory performance. Psychol Sci. 2013;24(9):1770–9.

Article  PubMed  Google Scholar 

Kim JM, Stewart R, Bae KY, Kim SW, Yang SJ, Park KH, Shin IS, Yoon JS. Role of BDNF val66met polymorphism on the association between physical activity and incident dementia. Neurobiol Aging. 2011;32(3):551.e555-512.

Article  Google Scholar 

Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA, Benzinger T, Holtzman DM, Morris JC. Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol. 2012;69(5):636–43.

Article  PubMed  PubMed Central  Google Scholar 

Brown BM, Peiffer JJ, Taddei K, Lui JK, Laws SM, Gupta VB, Taddei T, Ward VK, Rodrigues MA, Burnham S, et al. Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Mol Psychiatry. 2013;18(8):875–81.

Article  CAS  PubMed  Google Scholar 

Jensen CS, Simonsen AH, Siersma V, Beyer N, Frederiksen KS, Gottrup H, Hoffman K, Høgh P, Frikke-Schmidt R, Sobol NA, et al. Patients with Alzheimer’s disease who carry the APOE ε4 allele benefit more from physical exercise. Alzheimers Dement (N Y). 2019;5:99–106.

Article  PubMed  Google Scholar 

Rodriguez FS, Schroeter ML, Arélin K, Witte AV, Baber R, Burkhardt R, Engel C, Löffler M, Thiery J, Villringer A, et al. APOE e4-genotype and lifestyle interaction on cognitive performance: results of the LIFE-Adult-study. Health Psychol. 2018;37(2):194–205.

Article  PubMed  Google Scholar 

Fisher GG, Ryan LH. Overview of the Health and Retirement Study and introduction to the special issue. Work Aging Retire. 2018;4(1):1–9.

Article  PubMed  Google Scholar 

Sonnega A, Faul JD, Ofstedal MB, Langa KM, Phillips JW, Weir DR. Cohort profile: the Health and Retirement Study (HRS). Int J Epidemiol. 2014;43(2):576–85.

Article  PubMed  PubMed Central  Google Scholar 

Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018;9(1):2098.

Article  PubMed  PubMed Central  Google Scholar 

Euesden J, Lewis CM, O’Reilly PF. PRSice: polygenic risk score software. Bioinformatics. 2015;31(9):1466–8.

Article  CAS  PubMed  Google Scholar 

Ware E, Gard A, Schmitz L, Faul J. HRS polygenic scores-release 4.3, 2006–2012 genetic data. Ann Arbor: Survey Research Center, Institute for Social Research, University of Michigan; 2020.

Google Scholar 

Fisher GG, Hassan H, Faul JD, Rodgers WL, Weir DR. Health and Retirement Study imputation of cognitive functioning measures: 1992–2014. 2017.

Google Scholar 

Liu T, Canon MD, Shen L, Marples BA, Colton JP, Lo WJ, Gray M, Li C. The influence of the BDNF Val66Met polymorphism on the association of regular physical activity with cognition among individuals with diabetes. Biol Res Nurs. 2021;23(3):318–30.

Article  CAS 

Comments (0)

No login
gif