Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Ca-a cancer Journal for Clinicians. 2021;71(3):209–49.
Schiffman M, Wentzensen N. Human papillomavirus infection and the multistage carcinogenesis of cervical cancer. Cancer Epidemiol Biomarkers Prev. 2013;22(4):553–60.
Article PubMed PubMed Central Google Scholar
de Freitas AC, Gurgel AP, Chagas BS, Coimbra EC. Do Amaral CM. Susceptibility to cervical cancer: an overview. Gynecol Oncol. 2012;126(2):304–11.
Wojcik GL, Kao WH, Duggal P. Relative performance of gene- and pathway-level methods as secondary analyses for genome-wide association studies. BMC Genet. 2015;16(null):34.
Article PubMed PubMed Central Google Scholar
Magnusson PK, Lichtenstein P, Gyllensten UB. Heritability of cervical tumours. Int J Cancer. 2000;88(5):698–701.
Article CAS PubMed Google Scholar
Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015;125(9):3347–55.
Article PubMed PubMed Central Google Scholar
Sharma D, Kanneganti TD. The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation. J Cell Biol. 2016;213(6):617–29.
Article CAS PubMed PubMed Central Google Scholar
Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–87.
Article PubMed PubMed Central Google Scholar
Hamarsheh S, Zeiser R. NLRP3 inflammasome activation in Cancer: a double-edged Sword. Front Immunol. 2020;11(null):1444.
Article CAS PubMed PubMed Central Google Scholar
Wu Z, Wu S, Liang T. Association of NLRP3 rs35829419 and rs10754558 polymorphisms with risks of Autoimmune Diseases: a systematic review and Meta-analysis. Front Genet. 2021;12(null):690860.
Article CAS PubMed PubMed Central Google Scholar
Jalil M, Ghazi HF. NLRP3 inflammasome gene polymorphisms variably Associated with its serum levels in Acute myocardial infarction. Pakistan J Biol Sciences: PJBS. 2020;23(5):612–8.
Castaño-Rodríguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM. The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses. PLoS ONE. 2014;9(6):e98899.
Article PubMed PubMed Central Google Scholar
Zhang AQ, Zeng L, Gu W, Zhang LY, Zhou J, Jiang DP, et al. Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma. Crit Care. 2011;15(6):R280.
Article PubMed PubMed Central Google Scholar
Maes M, Tedesco Junior WLD, Lozovoy MAB, Mori MTE, Danelli T, Almeida ERD, et al. In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach. Mol Psychiatry. 2022;27(4):1945–55.
Article CAS PubMed PubMed Central Google Scholar
Ozbayer C, Kurt H, Yagci E, Kebapci MN, Gunes HV, Degirmenci I. NLRP3-Inflammasome gene variations in the risk of type 2 diabetes. J Environ Pathol Toxicol Oncol. 2022;41(2):1–13.
Xu G, Huang R, Xia W, Jiang B, Xiao G, Li Y. Associations between inflammasome-related gene NLRP3 polymorphisms (rs10754558 and rs35829419) and risk of bladder cancer in a chinese population. J Clin Lab Anal. 2021;35(11):e23973.
Article CAS PubMed PubMed Central Google Scholar
Yoganathan P, Rossel JB, Jordi SBU, Franc Y, Biedermann L, Misselwitz B, et al. Genotype-phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in swiss inflammatory bowel disease patients. BMC Gastroenterol. 2021;21(1):310.
Article CAS PubMed PubMed Central Google Scholar
Juneblad K, Kastbom A, Johansson L, Rantapää-Dahlqvist S, Söderkvist P, Alenius GM. Association between inflammasome-related polymorphisms and psoriatic arthritis. Scand J Rheumatol. 2021;50(3):206–12.
Article CAS PubMed Google Scholar
Hoppe MM, Sundar R, Tan DSP, Jeyasekharan AD. Biomarkers for homologous recombination Deficiency in Cancer. JNCI-Journal of the National Cancer Institute. 2018;110(7):704–13.
Deivendran S, Marzook KH, Radhakrishna Pillai M. The role of inflammation in cervical cancer. Adv Exp Med Biol. 2014;816(null):377–99.
Article CAS PubMed Google Scholar
Mahmoudiasl GR, Abbaszadeh HA, Rezaei-Tavirani M, Abdollahifar MA, Khoramgah MS, Niknazar S, et al. Nod-like receptor protein 3 and nod-like receptor protein 1 inflammasome activation in the hippocampal region of postmortem methamphetamine chronic user. Bratislava Med Journal-Bratislavske Lekarske Listy. 2019;120(10):769–76.
Zhang J, Xu Q, Sun W, Zhou X, Fu D, Mao L. New Insights into the role of NLRP3 inflammasome in Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease. J Inflamm Res. 2021;14(null):4155–68.
Article PubMed PubMed Central Google Scholar
Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z et al. NLRP3: A Novel Mediator in Cardiovascular Disease. Journal of Immunology Research. 2018;2018(null):5702103.
Li Z, Guo J, Bi L. Role of the NLRP3 inflammasome in autoimmune diseases. Biomedicine & pharmacotherapy. 2020;130(null):110542.
Ding Y, Yan Y, Dong Y, Xu J, Su W, Shi W, et al. NLRP3 promotes immune escape by regulating immune checkpoints: a pan-cancer analysis. Int Immunopharmacol. 2022;104(null):108512.
Article CAS PubMed Google Scholar
Wang Y, Zhang H, Xu Y, Peng T, Meng X, Zou F. NLRP3 induces the autocrine secretion of IL-1β to promote epithelial-mesenchymal transition and metastasis in breast cancer. Biochem Biophys Res Commun. 2021;560(null):72–9.
Article CAS PubMed Google Scholar
Deng Q, Geng Y, Zhao L, Li R, Zhang Z, Li K, et al. NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver. Cancer Lett. 2019;442(null):21–30.
Article CAS PubMed Google Scholar
Boone BA, Murthy P, Miller-Ocuin JL, Liang X, Russell KL, Loughran P, et al. The platelet NLRP3 inflammasome is upregulated in a murine model of pancreatic cancer and promotes platelet aggregation and tumor growth. Ann Hematol. 2019;98(7):1603–10.
Article CAS PubMed PubMed Central Google Scholar
Daley D, Mani VR, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214(6):1711–24.
Article CAS PubMed PubMed Central Google Scholar
Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, et al. The Nlrp3 Inflammasome suppresses Colorectal Cancer Metastatic Growth in the liver by promoting natural killer cell tumoricidal activity. Immunity. 2015;43(4):751–63.
Article CAS PubMed Google Scholar
Zhang Y, Yang H, Sun M, He T, Liu Y, Yang X, et al. Alpinumisoflavone suppresses hepatocellular carcinoma cell growth and metastasis via NLRP3 inflammasome-mediated pyroptosis. Pharmacol Rep. 2020;72(5):1370–82.
Article CAS PubMed Google Scholar
He A, Shao J, Zhang Y, Lu H, Wu Z, Xu Y. CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway. Oncotarget. 2017;8(20):33214–24.
Article PubMed PubMed Central Google Scholar
Griffin DE. The Immune response in Measles: Virus Control, Clearance and Protective immunity. Viruses. 2016;8(10):null.
Keskin S, Tatlıpınar A, Ata P. A New Biomarker on Bone Resorption in Chronic Otitis Media: osteoprotegerin and NLRP3 inflammasome gene polymorphisms. Indian J Otolaryngol Head Neck Surg. 2022;74(2):205–11.
Slezakova S, Borilova Linhartova P, Masopustova L, Bartova J, Petanova J, Kuklinek P, et al. Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the czech population. J oral Pathol Med. 2018;47(4):434–9.
Article CAS PubMed Google Scholar
Ungerbäck J, Belenki D, Jawad ul-Hassan A, Fredrikson M, Fransén K, Elander N, et al. Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Carcinogenesis. 2012;33(11):2126–34.
Cambui RAG, do Espírito Santo GF, Fernandes FP, Leal VNC, Galera BB, Fávaro EGP, et al. Double-edged sword of inflammasome genetics in colorectal cancer prognosis. Clin Immunol. 2020;213(null):108373.
Comments (0)