Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Investig. 2010;120:3779–87.
Article CAS PubMed PubMed Central Google Scholar
Gauriau C. Posterior triangular thalamic neurons convey nociceptive messages to the secondary somatosensory and insular cortices in the rat. J Neurosci. 2004;24:752–61.
Article CAS PubMed PubMed Central Google Scholar
Lu C, Yang T, Zhao H, Zhang M, Meng F, Fu H, et al. Insular cortex is critical for the perception, modulation, and chronification of pain. Neurosci Bull. 2016;32:191–201.
Article CAS PubMed PubMed Central Google Scholar
Garcia-Larrea L, Peyron R. Pain matrices and neuropathic pain matrices: a review. Pain. 2013;154:S29-43.
Jasmin L, Rabkin SD, Granato A, Boudah A, Ohara PT. Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex. Nature. 2003;424:316–20.
Article CAS PubMed Google Scholar
Alonso-Matielo H, Gonçalves ES, Campos M, Oliveira VRS, Toniolo EF, Alves AS, et al. Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry. Brain Res. 2021;1754: 147237.
Article CAS PubMed Google Scholar
Kawaguchi Y, Kondo S. Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex. J Neurocytol. 2002;31:277–87.
Pigott T, McPeak A, de Chastelain A, DeMayo MM, Rasic N, Rayner L, et al. Changes in brain GABA and glutamate and improvements in physical functioning following intensive pain rehabilitation in youth with chronic pain. J Pain. 2023;24:1288–97.
Article CAS PubMed Google Scholar
LaGraize SC. GABA(A) but not GABA(B) receptors in the rostral anterior cingulate cortex are involved in supraspinal modulation of nociception. 2007;18:1199–1216.
Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, et al. A neuronal circuit for activating descending modulation of neuropathic pain. Nat Neurosci. 2019;22:1659–68.
Article CAS PubMed Google Scholar
Urien L, Wang J. Top-down cortical control of acute and chronic pain. Psychosom Med. 2019;81:851–8.
Article PubMed PubMed Central Google Scholar
Zhuo M. Cortical excitation and chronic pain. Trends Neurosci. 2008;31:199–207.
Article CAS PubMed Google Scholar
Watson CJ. Insular balance of glutamatergic and GABAergic signaling modulates pain processing. Pain. 2016;157:2194–207.
Article CAS PubMed Google Scholar
Singh A, Patel D, Li A, Hu L, Zhang Q, Liu Y, et al. Mapping cortical integration of sensory and affective pain pathways. Curr Biol. 2020;30:1703-1715.e5.
Article CAS PubMed PubMed Central Google Scholar
Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, et al. A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nat Neurosci. 2017;20:1591–601.
Comments (0)