Abulkhair O, Al Balwi M, Makram O, Alsubaie L, Faris M, Shehata H, Ibrahim E et al (2018) Prevalence of BRCA1 and BRCA2 mutations among high-risk Saudi patients with breast cancer. J Globo Oncol 4(18):00066

Google Scholar 

Adnane J, Jackson RJ, Nicosia SV, Cantor AB, Pledger WJ, Sebti SMJO (2000) Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene 19:5338–5347

Article  CAS  PubMed  Google Scholar 

Agarwal E, Brattain MG, Chowdhury S (2013) Cell survival and metastasis regulation by Akt signaling in colorectal cancer. Cell Signal 25:1711–1719

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Thoubaity FK (2020) Molecular classification of breast cancer: A retrospective cohort study. Ann Med Surg 49:44–48

Article  Google Scholar 

Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Philips MR et al (2019) KRAS4A directly regulates hexokinase 1. Nature 576:482–486

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andrikopoulou A, Chatzinikolaou S, Panourgias E, Kaparelou M, Liontos M, Dimopoulos M-A, Zagouri F (2022) The emerging role of capivasertib in breast cancer. Breast 63:157–167

Article  PubMed  PubMed Central  Google Scholar 

Avalle L, Pensa S, Regis G, Novelli F, Poli V (2012) STAT1 and STAT3 in tumorigenesis: a matter of balance. JAK-STAT 1:65–72

Article  PubMed  PubMed Central  Google Scholar 

Ayati A, Moghimi S, Salarinejad S, Safavi M, Pouramiri B, Foroumadi A (2020) A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy. Bioorg Chem 99:103811

Article  CAS  PubMed  Google Scholar 

Baselga J, Gómez P, Greil R, Braga S, Climent MA, Wardley AM, Awada A et al (2013) Randomized phase II study of the anti-epidermal growth factor receptor monoclonal antibody cetuximab with cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer. J Clin Oncol 31:2586–2592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bean J, Riely GJ, Balak M, Marks JL, Ladanyi M, Miller VA, Pao W (2008) Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin Cancer Res 14:7519–7525

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becker S, Groner B, Müller CWJN (1998) Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature 394:145–151

Article  CAS  PubMed  Google Scholar 

Bemanian V, Sauer T, Touma J, Lindstedt BA, Chen Y, Ødegård HP, Geisler J et al (2015) The epidermal growth factor receptor (EGFR/HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer. PLoS ONE 10(8):e0134398

Article  PubMed  PubMed Central  Google Scholar 

Benmebarek MR, Karches CH, Cadilha BL, Lesch S, Endres S, Kobold S (2019) Killing mechanisms of chimeric antigen receptor (CAR) T cells. Int J Mol Sci 20:1283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattacharyya GS, Doval DC, Desai CJ, Chaturvedi H, Sharma S, Somashekhar SP (2020) Overview of breast cancer and implications of overtreatment of early-stage breast cancer: an indian perspective. J Glob Oncol 6:789–798

Article  Google Scholar 

Bhushan A, Gonsalves A, Menon JU (2021) Current state of breast cancer diagnosis, treatment, and theranostics. Pharmaceutics 13:723

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian Y, Yu Y, Wang S, Li LJB (2015) Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. Biochem Biophys Res Commun 463:612–617

Article  CAS  PubMed  Google Scholar 

Blick SK, Scott LJ (2007) Cetuximab. Drugs 67:2585–2607

Article  CAS  PubMed  Google Scholar 

Bode U, Massimino M, Bach F, Zimmermann M, Khuhlaeva E, Westphal M, Fleischhack G (2012) Nimotuzumab treatment of malignant gliomas. Expert Opin Biol Ther 12:1649–1659

Article  CAS  PubMed  Google Scholar 

Bollu LR, Katreddy RR, Blessing AM, Pham N, Zheng B, Wu X, Weihua ZJO (2015) Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Oncotarget 6:34992

Article  PubMed  PubMed Central  Google Scholar 

Bonsu AB, Ncama BP (2019) Recognizing and appraising symptoms of breast cancer as a reason for delayed presentation in Ghanaian women: a qualitative study. PLoS ONE 14:e0208773

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowers M, Liang T, Gonzalez-Bohorquez D, Zocher S, Jaeger BN, Kovacs WJ, Jessberger S et al (2020) FASN-dependent lipid metabolism links neurogenic stem/progenitor cell activity to learning and memory deficits. Cell Stem Cell 27:98-109.e111

Article  CAS  PubMed  Google Scholar 

Brophy E, Conley J, O’Hearn P, Douglas M, Cheung C, Coco J, Keaney G et al (2013) Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119. Cancer Res 73:1891

Article  Google Scholar 

Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Greenberg MEJC et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868

Article  CAS  PubMed  Google Scholar 

Budhiarko D, Putra T, Harsono A, Masykura N, Tjindarbumi D, Widjajahakim G, Utomo A (2017) Frequency of L858R and L861Q EGFR mutation in triple-negative, luminal and HER2 of Indonesian breast cancers patients. Ann Oncol 28:171

Article  Google Scholar 

Bueno MJ, Quintela-Fandino M (2020) Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention. Mol Cell Oncol 7:1709389

Article  PubMed  PubMed Central  Google Scholar 

Burslem GM, Smith BE, Lai AC, Jaime-Figueroa S, McQuaid DC, Bondeson DP, Wang J et al (2018) The advantages of targeted protein degradation over inhibition: an RTK case study. Cell Chem Biol 25:67–77

Article  CAS  PubMed  Google Scholar 

Cai W-Q, Zeng L-S, Wang L-F, Wang Y-Y, Cheng J-T, Zhang Y, Wang X-W et al (2020) The latest battles between EGFR monoclonal antibodies and resistant tumor cells. Front Oncol 10:1249

Article  PubMed  PubMed Central  Google Scholar 

Caratelli S, Arriga R, Sconocchia T, Ottaviani A, Lanzilli G, Pastore D, Sconocchia G et al (2020) In vitro elimination of epidermal growth factor receptor-overexpressing cancer cells by CD32A-chimeric receptor T cells in combination with cetuximab or panitumumab. Int J Cancer 146:236–247

Article  CAS  PubMed  Google Scholar 

Carey LA, Rugo HS, Marcom PK, Mayer EL, Esteva FJ, Ma CX, Forero-Torres A et al (2012) TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. J Clin Oncol 30:2615

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carvalho MA, Zecchin KG, Seguin F, Bastos DC, Agostini M, Rangel AL, Graner E et al (2008) Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer 123:2557–2565

Article  CAS  PubMed  Google Scholar 

Chang D-Y, Ma W-L, Lu Y-SJT, Management CR (2021) Role of alpelisib in the treatment of PIK3CA-mutated breast cancer: patient selection and clinical perspectives. Ther Clin Risk Manag 17:193–207

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Ning Y, Bai G, Tong L, Zhang T, Zhou J, Duan W et al (2020b) Design, synthesis, and biological evaluation of IRAK4-targeting PROTACs. ACS Med Chem Lett 12:82–87

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Huang L, Dong Y, Tao C, Zhang R, Shao H, Shen H (2020a) Effect of AKT1 (p. E17K) hotspot mutation on malignant tumorigenesis and prognosics. Front Cell Dev Biol 8:573599

Article  PubMed  PubMed Central  Google Scholar 

Cheng C-S, Wang Z, Chen J (2014) Targeting FASN in breast cancer and the discovery of promising inhibitors from natural products derived from traditional chinese medicine. Evid Based Complement Altern Med 2014:232496

Article  Google Scholar 

Cheng H, Nair SK, Murray BW (2016) Recent progress on third generation covalent EGFR inhibitors. Bioorg Med Chem Lett 26:1861–1868

Article  CAS  PubMed  Google Scholar 

Chirala SS, Wakil SJJL (2004) Structure and function of animal fatty acid synthase. Lipids 39:1045–1053

Article  CAS  PubMed  Google Scholar 

Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Wakil SJ et al (2003) Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A 100:6358–6363

Article  CAS