Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals

Akladios B, Mendoza Reinoso V, Cain JE, Wang T, Lambie DL, Watkins DN, Beverdam A (2017) Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo. PLoS ONE 12(8):e0183178

Article  PubMed  PubMed Central  Google Scholar 

Alsamman S, Christenson SA, Yu A, Ayad NM, Mooring MS, Segal JM, Hu JK-H, Schaub JR, Ho SS, Rao V (2020) Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med 12(557):1–14

Article  Google Scholar 

Amali AA, Rekha RD, Lin CJ-F, Wang W-L, Gong H-Y, Her G-M, Wu J-L (2006a) Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci 13(2):225–232

Article  CAS  PubMed  Google Scholar 

Amali AA, Rekha RD, Lin CJ-F, Wang W-L, Gong H-Y, Her G-M, Wu J-L (2006b) Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci 13:2

Article  Google Scholar 

Ballestri S, Nascimbeni F, Romagnoli D, Lonardo A (2016) The independent predictors of non‐alcoholic steatohepatitis and its individual histological features. Insulin resistance, serum uric acid, metabolic syndrome, alanine aminotransferase and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment. Hepatol Res 46(11):1074–1087

Article  CAS  PubMed  Google Scholar 

Brunt EM (2010) Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 7(4):195–203

Article  PubMed  Google Scholar 

Bruschi FV, Tardelli M, Einwallner E, Claudel T, Trauner M (2020) PNPLA3 I148M up-regulates hedgehog and yap signaling in human hepatic stellate cells. Int J Mol Sci 21(22):8711

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai X, Wang J, Wang J, Zhou Q, Yang B, He Q, Weng Q (2020) Intercellular crosstalk of hepatic stellate cells in liver fibrosis: new insights into therapy. Pharmacol Res 155:104720

Article  CAS  PubMed  Google Scholar 

Choi SS, Omenetti A, Witek RP, Moylan CA, Syn W-K, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA (2009) Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol 297(6):G1093–G1106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chuang H-M, Su H-L, Li C, Lin S-Z, Yen S-Y, Huang M-H, Ho L-I, Chiou T-W, Harn H-J (2016) The role of butylidenephthalide in targeting the microenvironment which contributes to liver fibrosis amelioration. Front Pharmacol. https://doi.org/10.3389/fphar.2016.00112

Article  PubMed  PubMed Central  Google Scholar 

Cotton JL, Li Q, Ma L, Park J-S, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J (2017) YAP/TAZ and hedgehog coordinate growth and patterning in gastrointestinal mesenchyme. Dev Cell 43(1):35-47.e34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dechêne A, Sowa JP, Gieseler RK, Jochum C, Bechmann LP, El Fouly A, Schlattjan M, Saner F, Baba HA, Paul A (2010) Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology 52(3):1008–1016

Article  PubMed  Google Scholar 

Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y (2018) Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells. Gastroenterology 154(5):1465–1479

Article  CAS  PubMed  Google Scholar 

Ellis EL, Mann DA (2012) Clinical evidence for the regression of liver fibrosis. J Hepatol 56(5):1171–1180

Article  PubMed  Google Scholar 

Fang Y, Liu C, Shu B, Zhai M, Deng C, He C, Luo M, Han T, Zheng W, Zhang J, Liu S (2018) Axis of serotonin-pERK-YAP in liver regeneration. Life Sci 209:490–497

Article  CAS  PubMed  Google Scholar 

Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88(1):125–172

Article  CAS  PubMed  Google Scholar 

Gao H, Bu Y, Wu Q, Wang X, Chang N, Lei L, Chen S, Liu D, Zhu X, Hu K (2015) Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish. J Cell Sci 128(12):2340–2350

Article  CAS  PubMed  Google Scholar 

Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, Wu H (2019) Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway. Biochem Biophys Res Commun 516(4):1222–1228

Article  CAS  PubMed  Google Scholar 

George SM, Lu F, Rao M, Leach LL, Gross JM (2021) The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems. Prog Retin Eye Res 85:100969

Article  PubMed  PubMed Central  Google Scholar 

Ghuloum FI, Johnson CA, Riobo-Del Galdo NA, Amer MH (2022) From mesenchymal niches to engineered in vitro model systems: exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling. Mater Today Bio 17:100502

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halder G, Johnson RL (2011) Hippo signaling: growth control and beyond. Development (cambridge, England) 138(1):9–22

Article  CAS  PubMed  Google Scholar 

Hammes TO, Pedroso GL, Hartmann CR, Escobar TDC, Fracasso LB, da Rosa DP, Marroni NP, Porawski M, da Silveira TR (2012) The effect of taurine on hepatic steatosis induced by thioacetamide in zebrafish (Danio rerio). Dig Dis Sci 57(3):675–682

Article  CAS  PubMed  Google Scholar 

Han S, Bai E, Jin G, He C, Guo X, Wang L, Li M, Ying X, Zhu Q (2014) Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular carcinoma. J Immunol Res 2014:1–10

CAS  Google Scholar 

Henderson JM, Polak N, Chen J, Roediger B, Weninger W, Kench JG, McCaughan GW, Zhang HE, Gorrell MD (2018) Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. Sci Rep 8(1):1–12

Article  Google Scholar 

Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 12(9):2730–2741

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Sun S, Jiang Q, Sun S, Wang W, Gui Y, Song H (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (Danio rerio). Int J Biol Sci 9(3):267–278

Article  PubMed  PubMed Central  Google Scholar 

Huo X, Li H, Li Z, Yan C, Mathavan S, Liu J, Gong Z (2019a) Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in krasG12V transgenic zebrafish. Biochem Biophys Res Commun 510(4):558–564

Article  CAS  PubMed  Google Scholar 

Huo X, Li H, Li Z, Yan C, Agrawal I, Mathavan S, Liu J, Gong Z (2019b) Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Sci Rep 9(1):1–11

Article  Google Scholar 

Jiang Q, Liu D, Gong Y, Wang Y, Sun S, Gui Y, Song H (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem Biophys Res Commun 384(1):114–119

Article  CAS  PubMed  Google Scholar 

Jin L, Huang H, Ni J, Shen J, Liu Z, Li L, Fu S, Yan J, Hu B (2021) Shh-Yap signaling controls hepatic ductular reactions in CCl4-induced liver injury. Environ Toxicol 36(2):194–203

Article  CAS  PubMed  Google Scholar 

Johnson RL (2019) Hippo signaling and epithelial cell plasticity in mammalian liver development, homeostasis, injury and disease. Sci China Life Sci 62(12):1609–1616

Article  PubMed  Google Scholar 

Katoch S, Patial V (2021) Zebrafish: an emerging model system to study liver diseases and related drug discovery. J Appl Toxicol 41(1):33–51

Article  CAS  PubMed  Google Scholar 

Kinkel MD, Eames SC, Philipson LH, Prince VE (2010) Intraperitoneal injection into adult zebrafish. JoVE 42:e2126

Google Scholar 

Kisseleva T, Brenner DA (2008) Mechanisms of fibrogenesis. Exp Biol Med 233(2):109–122

Article  CAS  Google Scholar 

Kojic S, Radojkovic D, Faulkner G (2011) Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. Crit Rev Clin Lab Sci 48(5–6):269–294

Article  CAS  PubMed  Google Scholar 

Kumar V, Dong Y, Kumar V, Almawash S, Mahato RI (2019) The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis. Theranostics 9(25):7537–7555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam SH, Wu YL, Vega VB, Miller LD, Spitsbergen J, Tong Y, Zhan H, Govindarajan KR, Lee S, Mathavan S (2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol 24(1):73–75

Article  CAS  PubMed 

Comments (0)

No login
gif