aDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan

bCL Laboratory LLC, Gaithersburg, Maryland

cAdepthera LLC, San Jose, California, USA

Correspondence to Sheau Yu Teddy Hsu, Adepthera LLC, San Jose, CA 95138, USA. E-mail: [email protected]

Abbreviations: ADM, adrenomedullin; AMBP-1, adrenomedullin-binding protein; ASA, acetylsalicylic acid; BW, body weight; CGRP, calcitonin gene-related peptide; CLR, calcitonin receptor-like receptor; FBS, fetal bovine serum; FGR, fetal growth restriction; HLME, human lymphatic microvascular endothelial; MAP, mean arterial pressure; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RAMP, receptor activity-modifying protein; RUPP, reduced uteroplacental perfusion pressure; sFlt-1, soluble fms-like tyrosine kinase 1; SHR, spontaneously hypertensive rats; VEGF, vascular endothelial growth factor

Received 1 September, 2022

Revised 12 March, 2023

Accepted 12 March, 2023

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