Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling for the subtyping of primary aldosteronism: a prospective study

aDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China

bDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China

cDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China

dBranch of National Clinical Research Center for Metabolic Diseases, Nanjing, China

Correspondence to Ping Li, MD, Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China, 210008 E-mail: [email protected]

Abbreviations: ACTH, adrenocorticotropic hormone; APA, aldosterone-producing adenoma; ARR, aldosterone-to-renin ratio; AVIS, Adrenal Vein sampling International Study; AVS, adrenal venous sampling; CCT, captopril challenge test; CT, computed tomography; CV, coefficient of variation; IVC, inferior vena cava; LAV, left adrenal vein; MRAs, mineralocorticoid receptor antagonists; PA, primary aldosteronism; PAC, plasma aldosterone concentration; PASO, Primary Aldosteronism Surgery Outcome; PCC, plasma cortisol concentration; PRA, plasma renin activity; RASI, relative aldosterone secretion index; RAV, right adrenal vein; ROC, receiver operating characteristic

Received 24 November, 2023

Revised 23 January, 2024

Accepted 31 January, 2024

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