Νikolouzakis Τ, Mariolis-Sapsakos T, Triantopoulou C, De Bree E, Xynos E, Chrysos E, et al. Detailed and applied anatomy for improved rectal cancer treatment. Ann Gastroenterol. 2019;32(5):431–40. https://doi.org/10.20524/aog.2019.0407.

Article  Google Scholar 

Stewart CJ, Hillery S, Platell C, Puppa G. Assessment of serosal invasion and criteria for the classification of pathological (p) t4 staging in colorectal carcinoma: confusions, controversies and criticisms. Cancers (Basel). 2011;3(1):164–81. https://doi.org/10.3390/cancers3010164.

Article  Google Scholar 

Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, et al. A review of neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Int J Biol Sci. 2016;12(8):1022–31. https://doi.org/10.7150/ijbs.15438.

Article  CAS  Google Scholar 

Thomas PR, Lindblad AS. Adjuvant postoperative radiotherapy and chemotherapy in rectal carcinoma: a review of the Gastrointestinal Tumor Study Group experience. Radiother Oncol. 1988;13(4):245–52. https://doi.org/10.1016/0167-8140(88)90219-8.

Article  CAS  Google Scholar 

Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351(17):1731–40. https://doi.org/10.1056/NEJMoa040694.

Article  CAS  Google Scholar 

Harris DA, Thorne K, Hutchings H, Islam S, Holland G, Hatcher O, et al. Protocol for a multicentre randomised feasibility trial evaluating early surgery alone in low rectal cancer (SAILOR). BMJ Open. 2016;6(11):e012496. https://doi.org/10.1136/bmjopen-2016-012496.

Article  Google Scholar 

Guillem JG, Díaz-González JA, Minsky BD, Valentini V, Jeong SY, Rodriguez-Bigas MA, et al. cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol. 2008;26(3):368–73. https://doi.org/10.1200/jco.2007.13.5434.

Article  Google Scholar 

Hepner A, Negrini D, Hase EA, Exman P, Testa L, Trinconi AF, et al. Cancer during pregnancy the oncologist overview. World J Oncol. 2019;10(1):28–34. https://doi.org/10.14740/wjon1177.

Article  CAS  Google Scholar 

Donegan WL. Cancer and pregnancy. CA Cancer J Clin. 1983;33(4):194–214. https://doi.org/10.3322/canjclin.33.4.194.

Article  CAS  Google Scholar 

Woods JB, Martin JN Jr, Ingram FH, Odom CD, Scott-Conner CE, Rhodes RS. Pregnancy complicated by carcinoma of the colon above the rectum. Am J Perinatol. 1992;9(2):102–10. https://doi.org/10.1055/s-2007-994680.

Article  CAS  Google Scholar 

Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. CA a Cancer J Clin. 2020;70(3):145–64.

Article  Google Scholar 

Yoon I, Slesinger TL. Radiation exposure in pregnancy. StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.

Ogilvy-Stuart AL, Shalet SM. Effect of radiation on the human reproductive system. Environ Health Perspect. 1993;101(Suppl 2):109–16. https://doi.org/10.1289/ehp.93101s2109.

Article  Google Scholar 

National Cancer Institue, Bethesda, MD. 2019. https://seer.cancer.gov/csr/1975_2016/. Accessed August 2019.

Teh WT, Stern C, Chander S, Hickey M. The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Biomed Res Int. 2014;2014:482968. https://doi.org/10.1155/2014/482968.

Article  Google Scholar 

Garcia M, Jemal A, Ward E, Center M, Hao Y, Siegel R, et al. Global cancer facts & figures 2007. Atlanta, GA: Ame Cancer Soc. 2007;1(3):52.

Google Scholar 

Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, et al. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2013;31(19):2500–10. https://doi.org/10.1200/jco.2013.49.2678.

Article  Google Scholar 

Lange MM, Marijnen CA, Maas CP, Putter H, Rutten HJ, Stiggelbout AM, et al. Risk factors for sexual dysfunction after rectal cancer treatment. Eur J Cancer. 2009;45(9):1578–88. https://doi.org/10.1016/j.ejca.2008.12.014.

Article  CAS  Google Scholar 

Wiltink LM, Chen TYT, Nout RA, Kranenbarg EM-K, Fiocco M, Laurberg S, et al. Health-related quality of life 14 years after preoperative short-term radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomised trial. Eur J Cancer. 2014;50(14):2390–8. https://doi.org/10.1016/j.ejca.2014.06.020.

Article  Google Scholar 

Bruheim K, Guren MG, Dahl AA, Skovlund E, Balteskard L, Carlsen E, et al. Sexual function in males after radiotherapy for rectal cancer. Int J Radiation Oncol*Biol*Phys. 2010;76(4):1012–7.

Article  Google Scholar 

Bruheim K, Tveit KM, Skovlund E, Balteskard L, Carlsen E, Fosså SD, et al. Sexual function in females after radiotherapy for rectal cancer. Acta Oncol. 2010;49(6):826–32. https://doi.org/10.3109/0284186x.2010.486411.

Article  Google Scholar 

Kunneman M, Stiggelbout AM, Marijnen CA, Pieterse AH. Probabilities of benefit and harms of preoperative radiotherapy for rectal cancer: what do radiation oncologists tell and what do patients understand? Patient Educ Couns. 2015;98(9):1092–8. https://doi.org/10.1016/j.pec.2015.05.009.

Article  Google Scholar 

Pieterse AH, Stiggelbout AM, Baas-Thijssen MC, van de Velde CJ, Marijnen CA. Benefit from preoperative radiotherapy in rectal cancer treatment: disease-free patients’ and oncologists’ preferences. Br J Cancer. 2007;97(6):717–24. https://doi.org/10.1038/sj.bjc.6603954.

Article  CAS  Google Scholar 

Dickstein DR, Marshall DC. Top, bottom or vers? Creating a more equitable health system for sexual and gender minority patients with prostate cancer. Nat Rev Urol. 2022. https://doi.org/10.1038/s41585-022-00600-6.

Article  Google Scholar 

Boehmer U, Ozonoff A, Miao X. An ecological analysis of colorectal cancer incidence and mortality: differences by sexual orientation. BMC Cancer. 2011;11:400. https://doi.org/10.1186/1471-2407-11-400.

Article  Google Scholar 

Boehmer U, Ozonoff A, Winter M, Berklein F, Potter J, Hartshorn KL, et al. Health-related quality of life among colorectal cancer survivors of diverse sexual orientations. Cancer. 2021;127(20):3847–55. https://doi.org/10.1002/cncr.33762.

Article  Google Scholar 

Boehmer U, Potter J, Clark MA, Ozonoff A, Winter M, Berklein F, et al. Assessing the relationship between symptoms and health care utilization in colorectal cancer survivors of different sexual orientations. Support Care Cancer. 2021;29(10):5821–30. https://doi.org/10.1007/s00520-021-06157-1.

Article  Google Scholar 

Braun H, Nash R, Tangpricha V, Brockman J, Ward K, Goodman M. Cancer in transgender people: evidence and methodological considerations. Epidemiol Rev. 2017;39(1):93–107. https://doi.org/10.1093/epirev/mxw003.

Article  Google Scholar 

Bertoncelli Tanaka M, Sahota K, Burn J, Falconer A, Winkler M, Ahmed HU, et al. Prostate cancer in transgender women: what does a urologist need to know? BJU Int. 2022;129(1):113–22. https://doi.org/10.1111/bju.15521.

Article  Google Scholar 

Lin D, Lehrer EJ, Rosenberg J, Trifiletti DM, Zaorsky NG. Toxicity after radiotherapy in patients with historically accepted contraindications to treatment (CONTRAD): an international systematic review and meta-analysis. Radiother Oncol. 2019;135:147–52. https://doi.org/10.1016/j.radonc.2019.03.006.

Article  Google Scholar 

Ekbom A, Helmick C, Zack M, Adami H-O. Ulcerative colitis and colorectal cancer. N Engl J Med. 1990;323(18):1228–33. https://doi.org/10.1056/nejm199011013231802.

Article  CAS  Google Scholar 

Najafimehr H, Aghdaei HA, Pourhoseingholi MA, Shalmani HM, Vahedian-Azimi A, Kroh M, et al. A systematic review and meta-analysis on the association between inflammatory bowel disease family history and colorectal cancer. Gastroenterol Res Pract. 2021;2021:4874459. https://doi.org/10.1155/2021/4874459.

Article  Google Scholar 

Lee Y-C, Hsieh C-C, Li C-Y, Chuang J-P, Lee J-C. Secondary cancers after radiation therapy for primary prostate or rectal cancer. World J Surg. 2016;40(4):895–905. https://doi.org/10.1007/s00268-015-3324-x.

Article  Google Scholar 

Baxter NN, Tepper JE, Durham SB, Rothenberger DA, Virnig BA. Increased risk of rectal cancer after prostate radiation: a population-based study. Gastroenterology. 2005;128(4):819–24. https://doi.org/10.1053/j.gastro.2004.12.038.

Article  Google Scholar 

Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, et al. Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2007;69(3):740–5. https://doi.org/10.1016/j.ijrobp.2007.04.028.

Article  Google Scholar 

Valentini V, Morganti AG, Gambacorta MA, Mohiuddin M, Doglietto GB, Coco C, et al. Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: a multicentric phase II study. Int J Radiat Oncol Biol Phys. 2006;64(4):1129–39. https://doi.org/10.1016/j.ijrobp.2005.09.017.

Article  Google Scholar 

Mohiuddin M, Marks G, Marks J. Long-term results of reirradiation for patients with recurrent rectal carcinoma. Cancer. 2002;95(5):1144–50. https://doi.org/10.1002/cncr.10799.

Article  Google Scholar 

Ng MK, Leong T, Heriot AG, Ngan SY. Once-daily reirradiation for rectal cancer in patients who have received previous pelvic radiotherapy. J Med Imaging Radiat Oncol. 2013;57(4):512–8. https://doi.org/10.1111/1754-9485.12057.

Article  Google Scholar 

Tepper JE, O’Connell M, Niedzwiecki D, Hollis DR, Benson AB 3rd, Cummings B, et al. Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control–final report of intergroup 0114. J Clin Oncol. 2002;20(7):1744–50. https://doi.org/10.1200/jco.2002.07.132.

Article  CAS  Google Scholar 

•• Wo JY, Anker CJ, Ashman JB, Bhadkamkar NA, Bradfield L, Chang DT, et al. Radiation therapy for rectal cancer: executive summary of an ASTRO clinical practice guideline. Prac Rad Oncol. 2021;11(1):13–25. https://doi.org/10.1016/j.prro.2020.08.004. (These practice guidelines indicate when radiation should be used for the treatment of rectal cancers based on the opinions of an executive committee.••)

Article  Google Scholar 

Sebag-Montefiore D, Stephens RJ, Steele R, Monson J, Grieve R, Khanna S, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373(9666):811–20. https://doi.org/10.1016/s0140-6736(09)60484-0.

Article  Google Scholar 

Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, et al. Rectal Cancer, Version 2.2018, NCCN Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2018;16(7):874–901. https://doi.org/10.6004/jnccn.2018.0061.

Article  Google Scholar 

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, et al. Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up†. Annals of Oncology. 2017;28:iv22–40. https://doi.org/10.1093/annonc/mdx224.

Article  CAS  Google Scholar 

Kennedy ED, Simunovic M, Jhaveri K, Kirsch R, Brierley J, Drolet S, et al. Safety and feasibility of using magnetic resonance imaging criteria to identify patients with “good prognosis” rectal cancer eligible for primary surgery: the phase 2 nonrandomized QuickSilver clinical trial. JAMA Oncol. 2019;5(7):961–6. https://doi.org/10.1001/jamaoncol.2019.0186.

Article  Google Scholar 

• Lord AC, Corr A, Chandramohan A, Hodges N, Pring E, Airo-Farulla C, et al. Assessment of the 2020 NICE criteria for preoperative radiotherapy in patients with rectal cancer treated by surgery alone in comparison with proven MRI prognostic factors: a retrospective cohort study. Lancet Oncol. 2022;23(6):793–801. https://doi.org/10.1016/s1470-2045(22)00214-5. (This study illustrates the importance of MRI as a tool to help identiy patients that might not require neoadjuvant radiation.•)

Article