Testicular metastasis in prostate cancer: A rare case of testicular metastasis diagnosed with 68Ga-PSMA and review of the literature

1. Bray, F, Ferlay, J, Soerjomataram, I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
Google Scholar | Crossref | Medline2. Litwin, MS, Tan, HJ. The diagnosis and treatment of prostate cancer: A review. JAMA 2017; 317: 2532–2542.
Google Scholar | Crossref | Medline3. Holm, HV, Dahl, AA, Klepp, OH, et al. Modern treatment of metastatic prostate cancer. Tidsskr Nor Laegeforen 2017; 137: 803–805.
Google Scholar | Crossref | Medline4. Kirkali, Z, Reid, R, Deane, RF, et al. Silent testicular metastasis from carcinoma of the prostate. Br J Urol 1990; 66(2): 205–207.
Google Scholar | Crossref | Medline5. Tu, SM, Reyes, A, Maa, A, et al. Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features. Cancer 2002; 94: 2610–2617.
Google Scholar | Crossref | Medline6. Bubendorf, L, Schöpfer, A, Wagner, U, et al. Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients. Hum Pathol 2000; 31(5): 578–583.
Google Scholar | Crossref | Medline | ISI7. Minner, S, Wittmer, C, Graefen, M, et al. High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer. Prostate 2011; 71: 281–288.
Google Scholar | Crossref | Medline8. Perera, M, Papa, N, Roberts, M, et al. Gallium-68 prostate-specific membrane antigen positron emission tomography in advanced prostate cancer-updated diagnostic utility, sensitivity, specificity, and distribution of prostate-specific membrane antigen-avid lesions: A systematic review and meta-analysis. Eur Urol 2020; 77(4): 403–417.
Google Scholar | Medline9. Barakat, A, Yacoub, B, Homsi, ME, et al. Role of early PET/CT imaging with 68Ga-PSMA in staging and restaging of prostate cancer. Sci Rep 2020; 10: 2705.
Google Scholar | Crossref10. da Cunha, ML, de Oliveira Rodrigues, C, de Araújo, MPL, et al. Solitary testicular metastasis from prostate cancer. A case report diagnosed by PET/CT with PSMA. Eur J Nucl Med Mol Imaging 2018; 45(5): 888–889.
Google Scholar | Crossref | Medline11. Gupta, M, Choudhury, PS, Rawal, S, et al. Oligometastasis to testis in prostate cancer: Role of gallium-68 prostate-specific membrane antigen positron-emission tomography computed tomography. World J Nucl Med 2021; 20(1): 113–116.
Google Scholar | Crossref | Medline12. Abou Heidar, NF, Bustros, G, El-Asmar, JM, et al. Isolated testicular metastasis diagnosed more than a decade and a half post primary treatment for prostate cancer. Case Rep Oncol Med 2019; 2019: 4956954.
Google Scholar | Medline13. Weiberg, D, Radner, H, Derlin, T, et al. Early detection of bilateral testicular metastases from prostatic adenocarcinoma using 68Ga-PSMA Ligand PET/CT. Clin Nucl Med 2017; 42(7): 563–564.
Google Scholar | Crossref | Medline14. Deeb, IA, Khdhir, MA, Bulbul, M, et al. Solitary metastasis of prostatic adenocarcinoma to the testicle detected by (68)Ga-prostate-specific membrane antigen positron emission tomography/computed tomography. Indian J Nucl Med 2020; 35: 61–62.
Google Scholar | Crossref | Medline15. Gupta, N, Dey, S, Verma, R, et al. Isolated testicular metastasis from prostate cancer detected on Ga-68 PSMA PET/CT scan. Nucl Med Mol Imaging 2020; 54(6): 319–323.
Google Scholar | Crossref | Medline16. Ege Aktas, G, Yürüt Çaloğlu, V, Akdere, H, et al. Biochemical recurrence of prostate cancer presenting as solitary testicular metastasis on 68Ga-labeled prostate-specific membrane antigen Ligand positron emission tomography/computed tomography. Clin Nucl Med 2018; 43(9): 699–700.
Google Scholar | Crossref | Medline17. Patel, SR, Richardson, RL, Kvols, L. Metastatic cancer to the testes: A report of 20 cases and review of the literature. J Urol 1989; 142(4): 1003–1005.
Google Scholar | Crossref | Medline18. Korkes, F, Gasperini, R, Korkes, KL, et al. Testicular metastases: A poor prognostic factor in patients with advanced prostate cancer. World J Urol 2009; 27(1): 113–115.
Google Scholar | Crossref | Medline19. Janssen, S, Bernhards, J, Anastasiadis, AG, et al. Solitary testicular metastasis from prostate cancer: A rare case of isolated recurrence after radical prostatectomy. Anticancer Res 2010; 30(5): 1747–1749.
Google Scholar | Medline20. Blacklock, AR . Testicular metastasis from carcinoma of the prostate. Br J Urol 1984; 56: 221–222.
Google Scholar | Crossref | Medline21. Lu, LY, Kuo, JY, Lin, A, et al. Metastatic tumors involving the testes. J Urol ROC 1999; 11: 12–16.
Google Scholar

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