1.
Grinspon, RP, Freire, AV, Rey, RA. Hypogonadism in pediatric health: adult medicine concepts fail. Trends Endocrinol Metab 2019; 30: 879–890.
Google Scholar |
Crossref |
Medline2.
Josso, N, Rey, RA, Picard, JY. Anti-müllerian hormone: a valuable addition to the toolbox of the pediatric endocrinologist. Int J Endocrinol 2013; 2013: 674105.
Google Scholar |
Crossref |
Medline3.
Weintraub, A, Eldar-Geva, T. Anti-mullerian hormone (AMH) determinations in the pediatric and adolescent endocrine practice. Pediatr Endocrinol Rev 2017; 14: 364–370.
Google Scholar |
Medline4.
Condorelli, RA, Cannarella, R, Calogero, AE, et al. Evaluation of testicular function in prepubertal children. Endocrine 2018; 62: 274–280.
Google Scholar |
Crossref |
Medline5.
Salonia, A, Rastrelli, G, Hackett, G, et al. Paediatric and adult-onset male hypogonadism. Nat Rev Dis Primers 2019; 5: 38.
Google Scholar |
Crossref |
Medline6.
Rey, RA, Grinspon, RP, Gottlieb, S, et al. Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach. Andrology 2013; 1: 3–16.
Google Scholar |
Crossref |
Medline7.
Rey, RA, Grinspon, RP. Normal male sexual differentiation and aetiology of disorders of sex development. Best Pract Res Clin Endocrinol Metab 2011; 25: 221–238.
Google Scholar |
Crossref |
Medline8.
Meroni, SB, Galardo, MN, Rindone, G, et al. Molecular mechanisms and signaling pathways involved in sertoli cell proliferation. Front Endocrinol 2019; 10: 224.
Google Scholar |
Crossref |
Medline9.
Lukas-Croisier, C, Lasala, C, Nicaud, J, et al. Follicle-stimulating hormone increases testicular anti-Müllerian hormone (AMH) production through Sertoli cell proliferation and a nonclassical cyclic adenosine 5’-monophosphate-mediated activation of the AMH gene. Mol Endocrinol 2003; 17: 550–561.
Google Scholar |
Crossref |
Medline10.
Lasala, C, Schteingart, HF, Arouche, N, et al. SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1. Am J Physiol Endocrinol Metab 2011; 301: E539–E547.
Google Scholar |
Crossref |
Medline11.
Lambert, AS, Bougneres, P. Growth and descent of the testes in infants with hypogonadotropic hypogonadism receiving subcutaneous gonadotropin infusion. Int J Pediatr Endocrinol 2016; 2016: 13.
Google Scholar |
Crossref |
Medline12.
Raivio, T, Toppari, J, Perheentupa, A, et al. Treatment of prepubertal gonadotrophin-deficient boys with recombinant human follicle-stimulating hormone. Lancet 1997; 350: 263–264.
Google Scholar |
Crossref |
Medline13.
Grinspon, RP, Bergadá, I, Rey, RA. Male hypogonadism and disorders of sex development. Front Endocrinol 2020; 11: 211.
Google Scholar |
Crossref |
Medline14.
Grinspon, RP, Loreti, N, Braslavsky, D, et al. Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys. Front Endocrinol 2014; 5: 51.
Google Scholar |
Crossref |
Medline15.
Braslavsky, D, Grinspon, RP, Ballerini, MG, et al. Hypogonadotropic hypogonadism in infants with congenital hypopituitarism: a challenge to diagnose at an early stage. Horm Res Paediatr 2015; 84: 289–297.
Google Scholar |
Crossref |
Medline16.
Bougnères, P, François, M, Pantalone, L, et al. Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone. J Clin Endocrinol Metab 2008; 93: 2202–2205.
Google Scholar |
Crossref |
Medline17.
Grinspon, RP, Gottlieb, S, Bedecarras, P, et al. Anti-Müllerian hormone and testicular function in prepubertal boys with cryptorchidism. Front Endocrinol 2018; 9: 182–114.
Google Scholar |
Crossref |
Medline18.
Hildorf, S, Dong, L, Thorup, J, et al. Sertoli cell number correlates with serum inhibin B in infant cryptorchid boys. Sex Dev 2019; 13: 74–82.
Google Scholar |
Crossref |
Medline19.
Xu, C, Lang-Muritano, M, Phan-Hug, F, et al. Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism. Clin Genet 2017; 92: 213–216.
Google Scholar |
Crossref |
Medline20.
Grinspon, RP, Castro, S, Brunello, FG, et al. Diagnosis of male central hypogonadism during childhood. J Endocr Soc 2021; 5: bvab145.
Google Scholar |
Crossref |
Medline21.
Mason, KA, Schoelwer, MJ, Rogol, AD. Androgens during infancy, childhood, and adolescence: physiology and use in clinical practice. Endocr Rev 2020; 41: 1–36.
Google Scholar |
Crossref22.
Grinspon, RP, Ropelato, MG, Bedecarrás, P, et al. Gonadotrophin secretion pattern in anorchid boys from birth to pubertal age: pathophysiological aspects and diagnostic usefulness. Clin Endocrinol 2012; 76: 698–705.
Google Scholar |
Crossref |
Medline23.
Bastida, MG, Rey, RA, Bergadá, I, et al. Establishment of testicular endocrine function impairment during childhood and puberty in boys with Klinefelter syndrome. Clin Endocrinol 2007; 67: 863–870.
Google Scholar |
Crossref |
Medline24.
Pacenza, N, Pasqualini, T, Gottlieb, S, et al. Clinical presentation of Klinefelter’s syndrome: differences according to age. Int J Endocrinol 2012; 2012: 324835.
Google Scholar |
Crossref |
Medline25.
Spaziani, M, Tarantino, C, Tahani, N, et al. Hypothalamo-Pituitary axis and puberty. Mol Cell Endocrinol 2021; 520: 111094.
Google Scholar |
Crossref |
Medline26.
Madsen, A, Oehme, NB, Roelants, M, et al. Testicular ultrasound to stratify hormone references in a cross-sectional norwegian study of male puberty. J Clin Endocrinol Metab 2020; 105: 1888–1898.
Google Scholar |
Crossref27.
Rey, RA . Mini-puberty and true puberty: differences in testicular function. Ann Endocrinol 2014; 75: 58–63.
Google Scholar |
Crossref |
Medline28.
Grinspon, RP, Bedecarrás, P, Ballerini, MG, et al. Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21. Int J Androl 2011; 34: e487–e498.
Google Scholar |
Crossref |
Medline29.
Kelsey, TW, Miles, A, Mitchell, RT, et al. A normative model of serum inhibin B in young males. PLoS One 2016; 11: e0153843.
Google Scholar |
Crossref |
Medline30.
Kelsey, TW, Li, LQ, Mitchell, RT, et al. A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years. PLoS One 2014; 9: e109346.
Google Scholar |
Crossref31.
Marshall, WA, Tanner, JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13–23.
Google Scholar |
Crossref |
Medline32.
Howard, SR, Dunkel, L. Delayed puberty-phenotypic diversity, molecular genetic mechanisms, and recent discoveries. Endocr Rev 2019; 40: 1285–1317.
Google Scholar |
Crossref |
Medline33.
Jonsdottir-Lewis, E, Feld, A, Ciarlo, R, et al. Timing of pubertal onset in girls and boys with constitutional delay. J Clin Endocrinol Metab 2021; 106: e3693–e3703.
Google Scholar |
Crossref |
Medline34.
Harrington, J, Palmert, MR. Clinical review: distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. J Clin Endocrinol Metab 2012; 97: 3056–3067.
Google Scholar |
Crossref |
Medline35.
Grinspon, RP, Ropelato, MG, Gottlieb, S, et al. Basal follicle-stimulating hormone and peak gonadotropin levels after gonadotropin-releasing hormone infusion show high diagnostic accuracy in boys with suspicion of hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2010; 95: 2811–2818.
Google Scholar |
Crossref |
Medline36.
Chaudhary, S, Walia, R, Bhansali, A, et al. FSH-stimulated inhibin B (FSH-iB): a novel marker for the accurate prediction of pubertal outcome in delayed puberty. J Clin Endocrinol Metab 2021; 106: e3495–e3505.
Google Scholar |
Crossref |
Medline37.
Grinspon, RP, Urrutia, M. The importance of follicle-stimulating hormone in the prepubertal and pubertal testis. Curr Opin Endocr Metab Res 2020; 14: 137–144.
Google Scholar |
Crossref38.
Bi, Y, Perry, PJ, Ellerby, M, et al. Population pharmacokinetic/pharmacodynamic modeling of depot testosterone cypionate in healthy male subjects. CPT Pharmacometrics Syst Pharmacol 2018; 7: 259–268.
Google Scholar |
Crossref |
Medline39.
Stancampiano, MR, Lucas-Herald, AK, Russo, G, et al. Testosterone therapy in adolescent boys: the need for a structured approach. Horm Res Paediatr 2019; 92: 215–228.
Google Scholar |
Crossref |
Medline40.
Varimo, T, Huopio, H, Kariola, L, et al. Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial. Lancet Child Adolesc Health 2019; 3: 109–120.
Google Scholar |
Crossref |
Medline41.
Vandewalle, S, Van Caenegem, E, Craen, M, et al. Growth, sexual and bone development in a boy with bilateral anorchia under testosterone treatment guided by the development of his monozygotic twin. J Pediatr Endocrinol Metab 2018; 31: 361–367.
Google Scholar |
Crossref |
Medline42.
Aydogdu, A, Swerdloff, RS. Emerging medication for the treatment of male hypogonadism. Expert Opin Emerg Drugs 2016; 21: 255–266.
Google Scholar |
Crossref |
Medline43.
Ladjouze, A, Donaldson, M. Primary gonadal failure. Best Pract Res Clin Endocrinol Metab 2019; 33: 101295.
Google Scholar |
Crossref |
Medline44.
Rogol, AD . Pubertal androgen therapy in boys. Pediatr Endocrinol Rev 2005; 2: 383–390.
Google Scholar |
Medline45.
Schurmeyer, T, Nieschlag, E. Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men. Int J Androl 1984; 7: 181–187.
Google Scholar |
Crossref |
Medline46.
Di Luigi, L, Sgrò, P, Romanelli, F, et al. Urinary and serum hormones profiles after testosterone enanthate administration in male hypogonadism: concerns on the detection of doping with testosterone in treated hypogonadal athletes. J Endocrinol Invest 2009; 32: 445–453.
Google Scholar |
Crossref |
Medline47.
Ekström, L, Schulze, JJ, Guillemette, C, et al. Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5’-diphospho-glucuronosyltransferase (UGT2B17) gene. Pharmacogenet Genomics 2011; 21: 325–332.
Google Scholar |
Crossref |
Medline48.
Zitzmann, M . Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men. Nat Clin Pract Urol 2007; 4: 161–166.
Google Scholar |
Crossref |
Medline49.
Morgentaler, A, Dobs, AS, Kaufman, JM, et al. Long acting testosterone undecanoate therapy in men with hypogonadism: results of a pharmacokinetic clinical study. J Urol 2008; 180: 2307–2313.
Google Scholar |
Crossref |
Medline50.
Nieschlag, E, Behre, HM. Testosterone therapy. In: Nieschlag, E, Behre, HM, Nieschlag, S (eds) Andrology. Berlin: Springer, 2010, pp. 437–455.
Google Scholar |
Crossref51.
Zhang, GY, Gu, YQ, Wang, XH, et al. A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men. J Androl 1998; 19: 761–768.
Comments (0)