Scheme S1: Solid phase synthesis of peptides 1 and 3 on MBHA resin using FOMC chemistry

Scheme S1: Solid phase synthesis of peptide 2 on MBHA resin using Boc chemistry

Scheme S2: Synthesis of (3R,4S)-1-N-Boc-3-N-Fmoc-4-hydroxycarbonylpyrrolidine

Table S1: Calculated and observed masses for peptides 1–3.

Figure S1: MALDI TOF-spectra of Peptide-1

Figure S2: MALDI TOF-spectra of Peptide-2

Figure S3: MALDI TOF-spectra of Peptide-3

Figure S4: HPLC profile of peptide-1

Figure S5: HPLC profile of Peptide-2

Figure S6: HPLC profile of Peptide-3

Figure S7:1HNMR, 13C NMR and DEPT NMR of compound 3

Figure S8:1HNMR, 13C NMR and DEPT NMR of compound 4

Figure S9:1HNMR, 13C NMR and DEPT NMR of compound 1

Figure S10: Mass spectra of Compound 4 and compound 1

Figure S11: Chiral HPLC profile of compound 4

Figure S12: a) Reduction in viability of PC12 cells when incubated with various concentrations of H2O2. b) PC12 cells incubated with various concentrations of peptide 1 and 3 show no change in DCF fluorescence.

Figure S13: The effect of peptides 1–3 on the life span of transgenic Drosophila expressing Aβ (42) in the CNS.DMSO; Pos. Control; peptide 2; peptide 1;peptide 3.