Problem

The aim of this study was to evaluate the sPD-L1 and sB7-H4 serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.

Method of the study

sPD-L1 and sB7-H4 levels were determined with ELISA. The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7-H4 and sPD-L1 measurements in each trimester of pregnancy.

Results

During the course of pregnancy the sB7-H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD-L1 levels increased significantly over the course of pregnancy.

Conclusion

The highest serum levels of sPD-L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7-H4 concentration levels in second trimester suggests different profile of T-cell regulation in physiological pregnancy.

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