Purpose

Neoadjuvant chemotherapy (NAC) is used in breast cancer before tumor surgery to reduce the size of the tumor and the risk of spreading. Monitoring the effects of NAC is important because in a number of cases the response to therapy is poor and requires a change in treatment. A new method that uses quantitative ultrasound to assess tumor response to NAC has been presented. The aim was to detect NAC unresponsive tumors at an early stage of treatment.

Methods

The method assumes that ultrasound scattering is different for responsive and non-responsive tumors. The assessment of the NAC effects was based on the differences between the histograms of the ultrasound echo amplitude recorded from the tumor after each NAC dose and from the tissue phantom, estimated using the Kolmogorov-Smirnov statistics (KSS) and the symmetrical Kullback-Leibler divergence (KLD). After therapy, tumors were resected and histopathologically evaluated. The percentage of residual malignant cells (RMC) was determined and was the basis for assessing the tumor response. The data set included ultrasound data obtained from 37 tumors. The performance of the methods was assessed by means of the area under the receiver operating characteristic curve (AUC).

Results

For responding tumors a decrease in the mean KLD and KSS values was observed after subsequent doses of NAC. In non-responding tumors the KLD was higher and did not change in subsequent NAC courses. Classification based on the KSS or KLD parameters allowed to detect tumors not responding to NAC after the first dose of the drug, with AUC equal 0.83±0.06 and 0.84±0.07 respectively. After the third dose, the AUC increased to 0.90±0.05 and 0.91±0.04 respectively.

Conclusions

The results indicate the potential usefulness of the proposed parameters in assessing the effectiveness of the NAC and early detection of non-responding cases.

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