Introduction/Aims

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) is frequently more severe in individuals with preexisting respiratory and cardiovascular conditions The impact on patients with neuromuscular disorders is concerning, but largely unknown. Late-onset Pompe disease (LOPD), is a lysosomal storage disorder characterized by progressive skeletal and respiratory muscle degeneration. Mortality is typically caused by respiratory failure. We examined the impact of COVID-19 on these patients.

Methods

This is a case Series of 4 patients with LOPD who contracted COVID-19.

Results

All patients experienced a mild/moderate illness from COVID-19 and did not require hospitalization. Neurological worsening occurred in one; with no change in physical ability in the other three, and respiratory symptoms remained stable in all four.

Discussion

COVID-19 infection can result in a benign course in some patients with LOPD. However, individuals with LOPD remain at high risk and should receive COVID-19 vaccinations and exercise precautions to avoid exposure to COVID-19 infection.