Title:Direct Modulation of the Gut Microbiota as a Therapeutic Approach for Alzheimer’s Disease

VOLUME: 21 ISSUE: 1

Author(s):Yi Wang* and Gary A. Dykes

Affiliation:School of Agriculture and Food Sciences, the University of Queensland, Keyhole Road, St Lucia, Queensland 4072, School of Agriculture and Food Sciences, the University of Queensland, Keyhole Road, St Lucia, Queensland 4072

Keywords:Alzheimer's disease, gut microbiota, probiotics, faecal microbiota transplantation, beta-amyloid, central nervous system.

Abstract:Alzheimer’s disease is a neurodegenerative disease characterized by a progressive decline in memory and cognitive functions. It is a multifactorial disease involving a wide range of pathological factors that are not fully understood. As supported by a growing amount of evidence in recent years, gut microbiota plays an important role in the pathogenesis of Alzheimer’s disease through the brain-gut-microbiota axis. This suggests that direct modulation of the gut microbiota can be a potential therapeutic target for Alzheimer’s disease. This review summarizes recent research findings on the modulation of the gut microbiota by probiotic therapies and faecal microbiota transplantation for controlling the pathologies of Alzheimer’s disease. Current limitations and future research directions of this field are also discussed.