Molecular mechanisms underlying the effect of diacerein on trichloroacetic acid–induced hepatic pre-neoplastic lesions in rats

1. Parkin, DM, Bray, F, Ferlay, J, et al. Global cancer statistics, 2002. CA: A Cancer J Clin 2005; 55(2), 74–108. DOI: 10.3322/canjclin.55.2.74
Google Scholar | Crossref | Medline | ISI2. Tagliabue, F, Burati, M, Chiarelli, M, et al. Left colonic metastasis from primary hepatocellular carcinoma. A case report. World J Clin Cases 2019; 7(15): 2044. DOI: 10.12998/wjcc.v7.i15.2044
Google Scholar | Crossref | Medline3. Castells, A, Bruix, J, Bru, C, et al. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology 1993; 18(5): 1121–1126.
Google Scholar | Medline4. Llovet, JM, Schwartz, M, Mazzaferro, V. Resection and liver transplantation for hepatocellular carcinoma. Semin Liver Dis 2005; 25(2): 181–200. DOI: 10.1055/s-2005-871198
Google Scholar | Crossref | Medline5. Libbrecht, L, Desmet, V, Roskams, T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 2005; 25(1), 16–27.‏
Google Scholar | Crossref | Medline6. Thoolen, B, Ten Kate, FJ, van Diest, PJ, et al. Comparative histomorphological review of rat and human hepatocellular proliferative lesions. J Toxicol Pathol 2012; 25(3): 189–199. DOI: 10.1293/tox.25.189
Google Scholar | Crossref | Medline7. Caldwell, JC, Keshava, N. Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis. Environ Health Perspect 2006; 114(9): 1457–1463.
Google Scholar | Crossref | Medline8. Alzergy, AA, Haman, MR, Shushni, MA, et al. Phyto-pharmaceuticals and biological study on graviola (Annona muricata L.) fruit and dietary supplement of graviola sold on the Libyan market as a cancer cure against TCA induce hepatotoxicity in mice.Cancer Biol Ther 2018; 8(2): 1–23.
Google Scholar9. Abdel-Hamid, NM, Morsy, MA. Novel biochemical pathways for 5-Fluorouracil in managing experimental hepatocellular carcinoma in rats. J Membr Biol 2010; 234(1): 29–34.
Google Scholar | Crossref | Medline10. Tao, L, Li, Y, Kramer, PM, et al. Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Toxicology 2004; 196(1–2): 127–136. DOI: 10.1016/j.tox.2003.11.011
Google Scholar | Crossref | Medline11. Culig, Z . Cytokine disbalance in common human cancers. Biochim Biophys Acta (BBA)-Molecular Cell Res 2011; 1813(2): 308–314.
Google Scholar | Crossref | Medline12. Gadotti, VM, Martins, DF, Pinto, HF, et al. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice. Pharmacol Biochem Behav 2012; 102(4): 549–554. DOI: 10.1016/j.pbb.2012.06.018
Google Scholar | Crossref | Medline13. Medhi, B, Singh, P, Prakash, A, et al. Diacerein: a new disease modulating agent in osteoarthritis. IJPMR 2007; 18 (2): 48–52. DOI: 10.1007/s11926-001-0061-y
Google Scholar | Crossref14. Bharti, R, Dey, G, Ojha, P, et al. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene 2016; 35(30): 3965–3975. DOI: 10.1038/onc.2015.466
Google Scholar | Crossref | Medline15. Sun, H, Luo, G, Chen, D, et al. A comprehensive and system review for the pharmacological mechanism of action of rhein, an active anthraquinone ingredient. Front Pharmacol 2016; 7: 247. DOI: 10.3389/fphar.2016.00247
Google Scholar | Crossref | Medline16. Tanaka, M, Kubo, O, Tajika, Y, et al. Immunohistochemical evaluation of intracranial recurrent meningiomas: correlation of topoisomerase II alpha expression and cell proliferative potential. No to Shinkei Brain Nerve 1999; 51(12): 1033–1039. DOI: 10.1152/ajpheart.1997.273.2.H687
Google Scholar | Crossref | Medline17. Mathews, MB, Bernstein, RM, Franza, BR, et al. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984; 309(5966): 374–376. DOI: 10.1038/309374a0
Google Scholar | Crossref | Medline18. Mayer, A, Takimoto, M, Fritz, E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71(8): 2454–2460. DOI: 10.1002/1097-0142(19930415)71:8<2454:aid-cncr2820710805>3.0.co;2–2
Google Scholar | Crossref | Medline19. Sharma, M, Piplani, S, Madan, M, et al. Hypoxia-induced factor-1 alpha, vascular endothelial growth factor expression in BRCA1-related breast cancer: a prospective study in tertiary care hospital. Indian J Pathol Microbiol 2017; 60(4): 469. DOI: 10.4103/IJPM.IJPM_524_16
Google Scholar | Crossref | Medline20. Lee, J-W, Bae, S-H, Jeong, J-W, et al. Hypoxia-inducible factor (HIF-1) α: its protein stability and biological functions. Exp Mol Med 2004; 36(1): 1–12. DOI: 10.1038/emm.2004.1
Google Scholar | Crossref | Medline | ISI21. Semenza, GL . Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med 2010; 2(3): 336–361. DOI: 10.1002/wsbm.69
Google Scholar | Crossref | Medline22. Bates, D, Curry, F. Vascular endothelial growth factor increases microvascular permeability via a Ca (2+)-dependent pathway. Am J Physiol-Heart Circulat Physiol 1997; 273(2): H687–H694. DOI: 10.1152/ajpheart.1997.273.2.H687
Google Scholar | Crossref23. Refaie, MM, El‐Hussieny, M. The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats. Fundam Clin Pharmacol 2017; 31(4): 438–444. DOI: 10.1111/fcp.12285
Google Scholar | Crossref | Medline24. Parasuraman, S, Raveendran, R, Kesavan, R. Blood sample collection in small laboratory animals. J Pharmacol Pharmacotherapeut 2010; 1(2): 87. DOI: 10.4103/0976-500X.72350
Google Scholar | Crossref | Medline25. Murray, R, Kaplan, A, Hammerman, RFF. Aminotransferases. C. Clin. Chem. St Louis. Toronto: C. V. Mosby. The CV Mosby Co., 1984; 1112–1119.
Google Scholar26. Ewees, MG, Messiha, BA, Abdel-Bakky, MS, et al. Tempol, a superoxide dismutase mimetic agent, reduces cisplatin-induced nephrotoxicity in rats. Drug Chem Toxicol 2019; 42(6): 657–664. DOI: 10.1080/01480545.2018.1485688
Google Scholar | Crossref | Medline27. Beuge, JA . Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302–311. DOI: 10.1016/s0076-6879(78)52032-6
Google Scholar | Crossref | Medline28. Shaker, ME . Nilotinib interferes with the signalling pathways implicated in acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol 2014; 114(3):263–270. DOI: 10.1111/bcpt.12144
Google Scholar | Crossref | Medline | ISI29. Koracevic, D, Koracevic, G, Djordjevic, V, et al. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 2001; 54(5): 356–361. DOI: 10.1136/jcp.54.5.356
Google Scholar | Crossref | Medline | ISI30. Altekruse, SF, McGlynn, KA, Dickie, LA, et al. Hepatocellular carcinoma confirmation, treatment, and survival in surveillance, epidemiology, and end results registries, 1992–2008. Hepatology 2012; 55(2): 476–482. DOI: 10.1002/hep.24710
Google Scholar | Crossref | Medline | ISI31. Segal, I, Rassekh, SR, Bond, MC, et al. Abnormal liver transaminases and conjugated hyperbilirubinemia at presentation of acute lymphoblastic leukemia. Pediatr Blood Cancer 2010; 55(3): 434–439. DOI: 10.1002/pbc.22549
Google Scholar | Crossref | Medline32. Wedemeyer, H, Hofmann, WP, Lueth, S, et al. ALT als Screeningparameter für Lebererkrankungen: eine kritische evaluation der Evidenz [ALT screening for chronic liver diseases: scrutinizing the evidence]. Z Fur Gastroenterol 2010; 48(1): 46–55. DOI: 10.1055/s-0028-1109980
Google Scholar | Crossref | Medline33. Zhang, L-x, Lv, Y, Xu, A-M, et al. The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma. BMC Cancer 2019; 19(1): 1–9. DOI: 10.1186/s12885-019-6011-8
Google Scholar | Crossref | Medline34. Du, Y, Du, B, Fang, X, et al. ALT flare predicts hepatocellular carcinoma among antiviral treated patients with chronic hepatitis b: a cross-country cohort study. Front Oncol 2021; 10: 615203. DOI: 10.3389/fonc.2020.615203
Google Scholar | Crossref | Medline35. Tarao, K, Takemiya, S, Tamai, S, et al. Relationship between the recurrence of hepatocellular carcinoma (HCC) and serum alanine aminotransferase levels in hepatectomized patients with hepatitis C virus-associated cirrhosis and HCC. Cancer 1997; 79(4): 688–694. DOI: 10.1002/(sici)1097-0142(19970215)79:4<688:aid-cncr5>3.0.co;2-a
Google Scholar | Crossref | Medline36. Benvegnu, L, Fattovich, G, Noventa, F, et al. Concurrent hepatitis B and C virus infection and risk of hepato-cellular carcinoma in cirrhosis. Cancer 1994; 74: 2442–2448. DOI: 10.1002/1097-0142(19941101)74:9<2442:aid-cncr2820740909>3.0.co;2-#
Google Scholar | Crossref | Medline37. Guo, H, Sun, J, Li, D, et al. Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. Biomed Pharmacother 2019; 112: 108704. DOI: 10.1016/j.biopha.2019.108704
Google Scholar | Crossref | Medline38. Xu, X, Yang, R, Wu, N, et al. Severe hypersensitivity dermatitis and liver dysfunction induced by occupational exposure to trichloroethylene. Ind Health 2009; 47(2): 107–112. DOI: 10.2486/indhealth.47.107
Google Scholar | Crossref | Medline | ISI39. Liao, T-Y, Liaw, C-C, Hsu, H-C, et al. Extrahepatic portal venous obstruction with hepatic enzyme elevation resembling hepatitis in patients with cancer. In vivo 2019; 33(5): 1697–1702. DOI: 10.21873/invivo.11658
Google Scholar | Crossref | Medline40. Hussein, UK, Mahmoud, HM, Farrag, AG, et al. Chemoprevention of diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in rats by sulfated polysaccharides and aqueous extract of Ulva lactuca. Integr Cancer Thera 2015; 14(6): 525–545. DOI: 10.1177/1534735415590157
Google Scholar | SAGE Journals | ISI41. Steinbeck, RG, Heselmeyer, KM, Moberger, HB, et al. The relationship between proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 during genesis of cervical carcinoma. Acta Oncol 1995; 34(2): 171–176. DOI: 10.3109/02841869509093952
Google Scholar | Crossref | Medline42. Wang, W, Zhu, M, Xu, Z, et al. Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity. Biol Res 2019; 52(1): 1–10. DOI: 10.1186/s40659-019-0242-7
Google Scholar | Crossref | Medline43. Asselin, E, Mills, GB, Tsang, BK. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res 2001; 61(5): 1862–1868.
Google Scholar | Medline44. Motohashi, N, Nagashima, H, Molnar, J. Trichloroethylene. II. Mechanism of carcinogenicity of trichloroethylene. In vivo (Athens, Greece) 1999; 13(3): 215–219. DOI: 10.2486/indhealth.47.107
Google Scholar | Crossref | Medline45. Walgren, JL, Kurtz, DT, McMillan, JM.

Comments (0)

No login
gif