Impact of TPOAb-negative maternal subclinical hypothyroidism in early pregnancy on adverse pregnancy outcomes

1. Alexander, EK, Pearce, EN, Brent, GA, et al. 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 2017; 27: 315–389.
Google Scholar | Crossref | Medline2. Chinese Society of Endocrinology . A guideline for diagnosis and management of thyroid diseases during pregnancy and postpartum. Chin J Endocrinol Metab 2012; 28: 354–371.
Google Scholar3. Maraka, S, Ospina, NM, O’Keeffe, DT, et al. Subclinical hypothyroidism in pregnancy: a systematic review and meta-analysis. Thyroid 2016; 26: 580–590.
Google Scholar | Crossref | Medline4. Stagnaro-Green, A, Abalovich, M, Alexander, E, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011; 21: 1081–1125.
Google Scholar | Crossref | Medline5. Blatt, AJ, Nakamoto, JM, Kaufman, HW. National status of testing for hypothyroidism during pregnancy and postpartum. J Clin Endocrinol Metab 2012; 97: 777–784.
Google Scholar | Crossref | Medline6. Li, C, Shan, Z, Mao, J, et al. Assessment of thyroid function during first-trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab 2014; 99: 73–79.
Google Scholar | Crossref | Medline7. Wiles, KS, Jarvis, S, Nelson-Piercy, C. Are we overtreating subclinical hypothyroidism in pregnancy? BMJ 2015; 351: h4726.
Google Scholar8. Javed, Z, Sathyapalan, T. Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther Adv Endocrinol Metab 2016; 7: 12–23.
Google Scholar | SAGE Journals9. Chinese Society of Endocrinology . Guideline on diagnosis and management of thyroid diseases during pregnancy and postpartum (2nd edition). Chin J Endocrinol Metab 2019; 35: 636–665.
Google Scholar10. Shan, ZY, Teng, WP. Hot controversial issues in management of thyroid disorders during pregnancy. Chin J Intern Med 2017; 56: 1–3.
Google Scholar | Medline11. Veltri, F, Kleynen, P, Grabczan, L, et al. Pregnancy outcomes are not altered by variation in thyroid function within the normal range in women free of thyroid disease. Eur J Endocrinol 2018; 178: 189–197.
Google Scholar | Crossref | Medline12. Cleary-Goldman, J, Malone, FD, Lambert-Messerlian, G, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynecol 2008; 112: 85–92.
Google Scholar | Crossref | Medline13. Ashoor, G, Maiz, N, Rotas, M, et al. Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death. Thyroid 2010; 20: 989–993.
Google Scholar | Crossref | Medline14. Liu, H, Shan, Z, Li, C, et al. Maternal subclinical hypothyroidism, thyroid autoimmunity, and the risk of miscarriage: a prospective cohort study. Thyroid 2014; 24: 1642–1649.
Google Scholar | Crossref | Medline15. Medici, M, Timmermans, S, Visser, W, et al. Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R Study. J Clin Endocrinol Metab 2013; 98: 59–66.
Google Scholar | Crossref | Medline16. Korevaar, TI, Schalekamp-Timmermans, S, de Rijke, YB, et al. Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: the generation R study. J Clin Endocrinol Metab 2013; 98: 4382–4390.
Google Scholar | Crossref | Medline17. Korevaar, TIM, Medici, M, Visser, TJ, et al. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol 2017; 13: 610–622.
Google Scholar | Crossref | Medline18. Plowden, TC, Schisterman, EF, Sjaarda, LA, et al. Thyroid-stimulating hormone, anti-thyroid antibodies, and pregnancy outcomes. Am J Obstet Gynecol 2017; 217: 697.e1–e7.
Google Scholar | Crossref | Medline19. Liu, TT, Teng, WP. Iodine nutrition status and thyroid disease in the Chinese. Chin J Intern Med 2017; 56: 62–64.
Google Scholar | Medline20. Dong, AC, Stagnaro-Green, A. Differences in diagnostic criteria mask the true prevalence of thyroid disease in pregnancy: a systematic review and meta-analysis. Thyroid 2019; 29: 278–289.
Google Scholar | Crossref | Medline21. Korevaar, TI, Medici, M, Peeters, RP. Subclinical hypothyroidism overdiagnosis in pregnant women. JAMA Intern Med 2015; 175: 1872–1873.
Google Scholar | Crossref | Medline22. Ying, H, Tang, YP, Bao, YR, et al. Maternal TSH level and TPOAb status in early pregnancy and their relationship to the risk of gestational diabetes mellitus. Endocrine 2016; 54: 742–750.
Google Scholar | Crossref | Medline23. Tudela, CM, Casey, BM, McIntire, DD, et al. Relationship of subclinical thyroid disease to the incidence of gestational diabetes. Obstet Gynecol 2012; 119: 983–988.
Google Scholar | Crossref | Medline24. Wilson, KL, Casey, BM, McIntire, DD, et al. Subclinical thyroid disease and the incidence of hypertension in pregnancy. Obstet Gynecol 2012; 119: 315–320.
Google Scholar | Crossref | Medline25. Nazarpour, S, Ramezani Tehrani, F, Simbar, M, et al. Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease. Eur J Endocrinol 2017; 176: 253–265.
Google Scholar | Crossref | Medline26. Thangaratinam, S, Tan, A, Knox, E, et al. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. BMJ 2011; 342: d2616.
Google Scholar | Crossref27. Negro, R, Schwartz, A, Gismondi, R, et al. Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy. J Clin Endocrinol Metab 2010; 95: E44–8.
Google Scholar | Crossref28. Sheehan, PM, Nankervis, A, Araujo Júnior, E, et al. Maternal thyroid disease and preterm birth: systematic review and meta-analysis. J Clin Endocrinol Metab 2015; 100: 4325–4331.
Google Scholar | Crossref | Medline29. Li, CL, Huang, H, Li, QH. Relationship of subclinical hypothyroidism with gestational diabetes mellitus during early pregnancy. Chin J Endocrinol Metab 2014; 30: 747–748.
Google Scholar30. Kent, NL, Young, SL, Akison, LK, et al. Is the link between elevated TSH and gestational diabetes mellitus dependant on diagnostic criteria and thyroid antibody status: a systematic review and meta-analysis. Endocrine 2021; 74: 38–49.
Google Scholar | Crossref | Medline31. Lee, SY. Subclinical hypothyroidism in pregnancy may have long-term effects on metabolic parameters. J Clin Endocrinol Metab 2020; 105: e2628-e2629.
Google Scholar | Crossref32. Arbib, N, Hadar, E, Sneh-Arbib, O, et al. First trimester thyroid stimulating hormone as an independent risk factor for adverse pregnancy outcome. J Matern Fetal Neonatal Med 2017; 30: 2174–2178.
Google Scholar | Crossref | Medline33. Parizad Nasirkandy, M, Badfar, G, Shohani, M, et al. The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: an updated systematic review and meta-analysis. Int J Reprod Biomed 2017; 15: 543–552.
Google Scholar | Crossref | Medline34. Lai, H, Zhan, ZY, Liu, H. Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study. J Int Med Res. Epub ahead of print 18 February 2020. DOI: 10.1177/0300060520904814.
Google Scholar | Crossref35. Casey, BM, Dashe, JS, Wells, CE, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol 2005; 105: 239–245.
Google Scholar | Crossref | Medline

Comments (0)

No login
gif