Efficacy and Safety of Subcutaneous Immunotherapy for Local Allergic Rhinitis: A Meta-Analysis of Randomized Controlled Trials

1. Powe, DG, Jagger, C, Kleinjan, A, et al. “Entopy”: localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy. 2003;33(10):1374–1379. 2003/10/02. doi: 10.1046/j.1365-2222.2003.01737.x.
Google Scholar | Crossref | Medline2. Campo, P, Rondón, C, Gould, HJ, et al. Local IgE in non-allergic rhinitis. Clin Exp Allergy. 2015;45(5):872–881. 2014/12/17. doi: 10.1111/cea.12476.
Google Scholar | Crossref | Medline3. Rondón, C, Doña, I, López, S, et al. Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response. Allergy 2008;63(10):1352–1358. 2008/09/11. doi: 10.1111/j.1398-9995.2008.01695.x.
Google Scholar | Crossref | Medline4. Rondón, C, Fernández, J, López, S, et al. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009;124(5):1005–1011. e1001. 2009/10/03. doi: 10.1016/j.jaci.2009.07.018.
Google Scholar | Crossref | Medline5. Rondón, C, Romero, JJ, López, S, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol. 2007;119(4):899–905. 2007/03/06. doi: 10.1016/j.jaci.2007.01.006.
Google Scholar | Crossref | Medline6. Dykewicz, MS, Wallace, DV, Amrol, DJ, et al. Rhinitis 2020: a practice parameter update. J Allergy Clin Immunol. 2020;146(4):721–767. 2020/07/25. doi: 10.1016/j.jaci.2020.07.007.
Google Scholar | Crossref | Medline7. Rondón, C, Campo, P, Togias, A, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129(6):1460–1467. 2012/04/21. doi: 10.1016/j.jaci.2012.02.032.
Google Scholar | Crossref | Medline8. Eguiluz-Gracia, I, Pérez-Sánchez, N, Bogas, G, et al. How to diagnose and treat local allergic rhinitis: a challenge for clinicians. J Clin Med. 2019;8(7):1062. 2019/07/25. doi: 10.3390/jcm8071062.
Google Scholar | Crossref9. Drazdauskaitė, G, Layhadi, JA, Shamji, MH. Mechanisms of allergen immunotherapy in allergic rhinitis. Curr Allergy Asthma Rep. 2020;21(1):2. 2020/12/15. doi: 10.1007/s11882-020-00977-7.
Google Scholar | Crossref | Medline10. Geller-Bernstein, C, Pibourdin, JM, Dornelas, A, et al. Efficacy of the acaricide: acardust for the prevention of asthma and rhinitis due to dust mite allergy, in children. Allerg Immunol (Paris). 1995;27(5):147–154. 1995/05/01.
Google Scholar | Medline11. Jutel, M, Agache, I, Bonini, S, et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136(3):556–568. 2015/07/15. doi: 10.1016/j.jaci.2015.04.047.
Google Scholar | Crossref | Medline12. Pfaar, O, Lou, H, Zhang, Y, et al. Recent developments and highlights in allergen immunotherapy. Allergy 2018;73(12):2274–2289. 2018/10/30. doi: 10.1111/all.13652.
Google Scholar | Crossref | Medline13. Bożek, A, Kołodziejczyk, K, Jarząb, J. Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology 2018;120(1):53–58. 2017/12/24. doi: 10.1016/j.anai.2017.10.009.
Google Scholar | Crossref | Medline14. Bozek, A, Winterstein, J, Galuszka, B, et al. Different development forms of local allergic rhinitis towards birch. BioMed Res Int. 2020;2020:3408561. 2020/07/01. doi: 10.1155/2020/3408561.
Google Scholar | Crossref | Medline15. Rondón, C, Blanca-López, N, Aranda, A, et al. Local allergic rhinitis: allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen. J Allergy Clin Immunol. 2011;127(4):1069–1071. 2011/02/01. doi: 10.1016/j.jaci.2010.12.013.
Google Scholar | Crossref | Medline16. Rondón, C, Blanca-López, N, Campo, P, et al. Specific immunotherapy in local allergic rhinitis: a randomized, double-blind placebo-controlled trial with Phleum pratense subcutaneous allergen immunotherapy. Allergy 2018;73(4):905–915. 2017/11/24. doi: 10.1111/all.13350.
Google Scholar | Crossref | Medline17. Rondón, C, Campo, P, Salas, M, et al. Efficacy and safety of D. Pteronyssinus immunotherapy in local allergic rhinitis: a double-blind placebo-controlled clinical trial. Allergy 2016;71(7):1057–1061. 2016/03/24. doi: 10.1111/all.12889.
Google Scholar | Crossref | Medline18. Dhami, S, Kakourou, A, Asamoah, F, et al. Allergen immunotherapy for allergic asthma: a systematic review and meta-analysis. Allergy 2017;72(12):1825–1848. 2017/05/26. doi: 10.1111/all.13208.
Google Scholar | Crossref | Medline19. Dhami, S, Nurmatov, U, Arasi, S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis. Allergy 2017;72(11):1597–1631. 2017/05/12. doi: 10.1111/all.13201.
Google Scholar | Crossref | Medline20. Feng, B, Wu, J, Chen, B, et al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: a meta-analysis of randomized controlled trials. Am J Rhinol Allergy. 2017;31(1):27–35. 2017/02/25. doi: 10.2500/ajra.2017.31.4382.
Google Scholar | SAGE Journals21. Kristiansen, M, Dhami, S, Netuveli, G, et al. Allergen immunotherapy for the prevention of allergy: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2017;28(1):18–29. 2016/09/23. doi: 10.1111/pai.12661.
Google Scholar | Crossref | Medline22. Nelson, H, Cartier, S, Allen-Ramey, F, et al. Network meta-analysis shows commercialized subcutaneous and sublingual grass products have comparable efficacy. J Allergy Clin Immunol Practice 2015;3(2):256–266. e253. 2015/01/23. doi: 10.1016/j.jaip.2014.09.018.
Google Scholar | Crossref | Medline23. Nurmatov, U, Dhami, S, Arasi, S, et al. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy 2017;72(8):1133–1147. 2017/01/07. doi: 10.1111/all.13124.
Google Scholar | Crossref | Medline24. Eguiluz-Gracia, I, Ariza, A, Testera-Montes, A, et al. Allergen immunotherapy for local respiratory allergy. Curr Allergy Asthma Rep. 2020;20(7):23. 2020/05/21. doi: 10.1007/s11882-020-00920-w.
Google Scholar | Crossref | Medline25. Shin, YS, Jung, CG, Park, HS. Prevalence and clinical characteristics of local allergic rhinitis to house dust mites. Curr Opin Allergy Clin Immunol. 2018;18(1):10–15. 2017/11/15. doi: 10.1097/aci.0000000000000413.
Google Scholar | Crossref | Medline26. Bousquet, J, Khaltaev, N, Cruz, AA, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy 2008;63(Suppl 86):8–160. 2008/03/26. doi: 10.1111/j.1398-9995.2007.01620.x.
Google Scholar | Crossref | Medline27. Juniper, EF, Guyatt, GH. Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis. Clin Experimental Allergy: J British Soc Allergy Clin Immunol 1991;21(1):77–83. 1991/01/01. doi: 10.1111/j.1365-2222.1991.tb00807.x.
Google Scholar | Crossref | Medline28. Bozek, A, Kolodziejczyk, K, Krajewska-Wojtys, A, et al. Pre-seasonal, subcutaneous immunotherapy: a double-blinded, placebo-controlled study in elderly patients with an allergy to grass. Ann Allergy Asthma Immunol. 2016;116(2):156–161. 2016/01/28. doi: 10.1016/j.anai.2015.12.013.
Google Scholar | Crossref | Medline29. Cheng, L, Chen, J, Fu, Q, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2018;10(4):300–353. 2018/06/28. doi: 10.4168/aair.2018.10.4.300.
Google Scholar | Crossref | Medline30. Aasbjerg, K, Backer, V, Lund, G, et al. Immunological comparison of allergen immunotherapy tablet treatment and subcutaneous immunotherapy against grass allergy. Clin Experimental Allergy: J British Soc Allergy Clin Immunol 2014;44(3):417–428. 2014/04/16. doi: 10.1111/cea.12241.
Google Scholar | Crossref | Medline31. Scadding, GW, Eifan, AO, Lao-Araya, M, et al. Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge. Allergy 2015;70(6):689–696. 2015/03/17. doi: 10.1111/all.12608.
Google Scholar | Crossref | Medline32. Stylianou, E, Ueland, T, Borchsenius, F, et al. Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scand J Clin Lab Invest. 2016;76(2):118–127. 2016/02/18. doi: 10.3109/00365513.2015.1110856.
Google Scholar | Crossref | Medline33. Djurup, R, Malling, HJ. High IgG4 antibody level is associated with failure of immunotherapy with inhalant allergens. Clin Allergy. 1987;17(5):459–468. 1987/09/01. doi: 10.1111/j.1365-2222.1987.tb02040.x.
Google Scholar | Crossref | Medline34. Feng, M, Zeng, X, Su, Q, et al. Allergen immunotherapy-induced immunoglobulin G4 reduces basophil activation in house dust mite-allergic asthma patients. Front Cell Dev Biol. 2020;8:30. 2020/03/11. doi: 10.3389/fcell.2020.00030.
Google Scholar | Crossref | Medline35. Francis, JN, James, LK, Paraskevopoulos, G, et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol. 2008;121(5):1120–1125. e1122. 2008/04/01. doi: 10.1016/j.jaci.2008.01.072.
Google Scholar | Crossref | Medline36. Groh, N, von Loetzen, CS, Subbarayal, B, et al. Ige and allergen-specific immunotherapy-induced IgG(4) recognize similar epitopes of Bet v 1, the major allergen of birch pollen. Clin Exp Allergy. 2017;47(5):693–703. 2016/10/23. doi: 10.1111/cea.12835.
Google Scholar | Crossref | Medline37. van Neerven, RJ, Wikborg, T, Lund, G, et al. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol (Baltimore, Md : 1950) 1999;163(5):2944–2952. 1999/08/24.
Google Scholar | Medline

Comments (0)

No login
gif